Antigenic Drift of Orientia tsutsugamushi in South Korea as Identified by the Sequence Analysis of a 56-kDa Protein-Encoding Gene

Park, Sang-Won; Lee, Chi Kug; Kwak, Yee Gyung; Moon, Chisook; Kim, Baek-Nam; Kim, Eu Suk; Kang, Jae Myung; Lee, Chang‐Seop

doi:10.4269/ajtmh.2010.09-0791

Cited by 21 publications

(31 citation statements)

References 26 publications

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“…However, in the Kyushu region, which is in southern Japan, the Kawasaki and Kuroki types are the major types and are transmitted by L. scutellare (7). Similarly, in South Korea, which is located close to the Kyushu region, Boryong is the major type and is considered identical to the Kuroki type based on its 56-kDa antigen gene sequence (8).…”

Section: Communicated By Masayuki Saijomentioning

confidence: 99%

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A Case of Scrub Typhus Imported from South Korea to Yamagata, Japan

et al. 2016

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Section: Communicated By Masayuki Saijomentioning

confidence: 99%

“…In this case, the patient harbored Kuroki (Boryong) type O. tsutsugamushi, which had not been reported in Yamagata so far. The Kuroki (Boryong) type accounts for about 70z of scrub typhus cases in South Korea (8) and its geographic distribution suggests that this case of the disease was imported from South Korea to Yamagata.…”

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A Case of Scrub Typhus Imported from South Korea to Yamagata, Japan

et al. 2016

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“…The genotypic distribution in the southern district of Korea included Boryong (88.4z), Kato (2.9z), Kawasaki (5.8z), Jecheon (1.4z), and Neimeng-65 (1.4z) (18). Another report on the genotypic distribution of O. tsutsugamushi strains that cause human infections in South Korea listed Boryong (68.6z), Taguchi (19.6z), Kanda/Kawasaki (9.2z), Jecheon (1.3z), and UAP7 (1.3z) (19). A clinical report that compared the Boryong and Karp genotypes of O. tsutsugamushi revealed no significant differences in disease severity between the 2 strains (20).…”

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Dynamics of Clinical Symptoms in Patients with Scrub Typhus

Lee

Chung

et al. 2013

Jpn J Infect Dis

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SUMMARY:The clinical manifestations and complications of scrub typhus are variable. Few studies have examined the timeline of clinical symptoms after the appropriate antimicrobial agents have been administered. The most prevalent clinical manifestations are fever and cough, followed by headache, myalgia, eschar, skin rash, and nausea. Systemic symptoms are most severe during the early stages of illness (i.e., the first 5 days), but resolve slowly within 2 weeks. The associated skin rash is most severe during the first 8 days of infection, but it resolves slowly within 21 days.Scrub typhus is a potentially fatal infectious disease caused by the organism Orientia tsutsugamushi (1). Typical signs include eschar formation and acute febrile illness with symptoms that include abrupt fever, chills, rash, lymphadenopathy, abdominal pain, and myalgia (2,3). The clinical manifestations and complications of scrub typhus vary; most symptoms are mild but severe complications have been reported, including acute respiratory distress syndrome, encephalitis, interstitial pneumonia, myocarditis and pericarditis, acute renal failure, and acute hepatic failure (4-10). Very few reports describe the clinical course beyond the occurrence of fever after the appropriate antimicrobial agents have been administered (11). An established timeline of the clinical symptoms may help physicians manage patients with scrub typhus more effectively.This study was conducted in 5 university medical centers in Korea between October and December 2010. In the current study, we used several diagnostic criteria for scrub typhus. First, a diagnosis of scrub typhus was made according to the World Health Organization criteria in 4 out of 5 hospitals when specific IgM antibody titers were equal to or greater than 1:10, or IgG titers were either equal to or greater than 1:256, or a 4-fold increase in titer was demonstrated using paired serum samples in an indirect immunofluorescence antibody (IFA) test (11,12). The O. tsutsugamushi strains used in the IFA test included Gilliam, Karp, Kato, and Boryong. Second, in the remaining hospital, O. tsutsugamushi was detected in passive hemagglutination assay (PHA) against O. tsutsugamushi with an antibody titer of 1:80 or greater in a single serum sample or 4-fold increase or greater during follow-up (13,14). The PHA was conducted using the Genedia Tsutsu PHA II test kit (Green Cross Corp., Yongin, Korea), which provides qualitative and quantitative detection of serum antibodies against O. tsutsugamushi. Sheep erythrocytes for the PHA were sensitized with the Karp and Gilliam strains, including the Boryong strain found in Korea (11,12).Respiratory symptoms included cough and dyspnea. Systemic symptoms included subjective fever, chills, headache, weight loss, and myalgia. Gastrointestinal symptoms included nausea, vomiting, diarrhea, and abdominal pain (15). Neurologic symptoms included mental confusion and delirium. Moreover, a skin rash was also observed. Symptom severity was scored using a 4-point scale: no symptoms...

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“…A positive serology test was defined as a fourfold or greater change in the titer or a titer 1:80 using the indirect fluorescence antibody test (IFA), which measured whole globulin in a single serum sample. 6 Positive nested PCR results were subsequently confirmed by sequencing of the 56 kDa type-specific antigen. 6 The PCR products were purified using a QIAquick gel extraction kit (QIAGEN, Hilden, Germany) and sequenced.…”

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Unusual Genotypic Distribution of Orientia tsutsugamushi Strains Causing Human Infections on Jeju Island

Yoo¹,

Heo²,

Koh³

et al. 2014

The American Society of Tropical Medicine and Hygiene

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Abstract. We investigated the clinical characteristics and serologic types of tsutsugamushi disease on the largest island of South Korea. There were 141 patients with tsutsugamushi disease at Jeju National University Hospital and Seogwipo Medical Center between November of 2003 and December of 2012. Median age of patients was 61 years, and 59% were women. The major clinical manifestations were fever (80.5%) and skin rash (55.7%), with eschars evident in 75

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Antigenic Drift of Orientia tsutsugamushi in South Korea as Identified by the Sequence Analysis of a 56-kDa Protein-Encoding Gene

Cited by 21 publications

References 26 publications

A Case of Scrub Typhus Imported from South Korea to Yamagata, Japan

A Case of Scrub Typhus Imported from South Korea to Yamagata, Japan

Dynamics of Clinical Symptoms in Patients with Scrub Typhus

Unusual Genotypic Distribution of Orientia tsutsugamushi Strains Causing Human Infections on Jeju Island

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