Antigenic characterization of intermediate adenovirus 14-11 strains associated with upper respiratory illness in a military camp

Hierholzer, John C.; Pumarola, A

doi:10.1128/iai.13.2.354-359.1976

Cited by 41 publications

(12 citation statements)

References 19 publications

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“…240 Several reports describing cases of respiratory infection by this unique AdV under other designations (AdV-11, 14-11 or genome type 11a, depending on the typing approach) can be found in the literature. 44,[292][293][294]…”

Section: Adenovirus Genotype 55mentioning

confidence: 99%

Adenovirus: Epidemiology, Global Spread of Novel Serotypes, and Advances in Treatment and Prevention

Lynch

Kajon

2016

Semin Respir Crit Care Med

412

178

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Adenoviruses (AdVs) are DNA viruses that typically cause mild infections involving the upper or lower respiratory tract, gastrointestinal tract, or conjunctiva. Rare manifestations of AdV infections include hemorrhagic cystitis, hepatitis, hemorrhagic colitis, pancreatitis, nephritis, or meningoencephalitis. AdV infections are more common in young children, due to lack of humoral immunity. Epidemics of AdV infection may occur in healthy children or adults in closed or crowded settings (particularly military recruits). The disease is more severe and dissemination is more likely in patients with impaired immunity (e.g., organ transplant recipients, human immunodeficiency virus infection). Fatality rates for untreated severe AdV pneumonia or disseminated disease may exceed 50%. More than 50 serotypes of AdV have been identified. Different serotypes display different tissue tropisms that correlate with clinical manifestations of infection. The predominant serotypes circulating at a given time differ among countries or regions, and change over time. Transmission of novel strains between countries or across continents and replacement of dominant viruses by new strains may occur. Treatment of AdV infections is controversial, as prospective, randomized therapeutic trials have not been conducted. Cidofovir is the drug of choice for severe AdV infections, but not all patients require treatment. Live oral vaccines are highly efficacious in reducing the risk of respiratory AdV infection and are in routine use in the military in the United States, but currently are not available to civilians.

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Section: Adenovirus Genotype 55mentioning

confidence: 99%

Adenovirus: Epidemiology, Global Spread of Novel Serotypes, and Advances in Treatment and Prevention

Lynch

Kajon

2016

Semin Respir Crit Care Med

412

178

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“…This value is similar to that obtained by the study of Kidd et al (21), in which a PCR-based identification method correlated 91.5% with the results of serotyping by NT. This discordance may be due to misidentification by NT or RE analysis, although the possibility cannot be excluded that the RE profiles of the targeted conserved regions of other adenovirus strains do not match the RE profiles demonstrated in this study and that intermediate strains may be encountered (3,8,17,27).…”

Section: Discussionmentioning

confidence: 54%

PCR and Restriction Endonuclease Analysis for Rapid Identification of Human Adenovirus Subgenera

Elnifro

Cooper

Klapper

et al. 2000

J. Clin. Microbiol.

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Subgenus identification of adenoviruses is of clinical importance and is as informative as identification by serotype in most clinical situations. A PCR-based identification of adenovirus subgenera A, B, C, D, E, and F and sometimes serotypes is described. The PCR uses nonnested primer pair ADRJC1-ADRJC2, which targets a highly conserved region of the adenovirus hexon gene, has a sensitivity of 10 to 40 copies of adenovirus type 2 (Ad2) DNA, and generates 140-bp PCR products from adenovirus serotypes representative of all the subgroups. The PCR products of all subgroups can be differentiated on the basis of the restriction fragment patterns produced by a total of five restriction endonucleases. In addition, serotypes Ad40 and Ad41 (subgroup F) and important serotypes of subgroup D (Ad8, Ad10, Ad19, and Ad37) can easily be differentiated, but serotypes within subgroups B and C cannot. The method was assessed by blind subgenus identification of 56 miscellaneous clinical isolates of adenoviruses. The identities of these isolates at the subgenus level by the PCR correlated 91% (51 of 56) with the results of serotyping by the neutralization test, and 9% (5 of 56) of clinical isolates produced discordant results.

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“…Genome stability of HAdV‐B3 and B7 has been investigated previously by comparing the full genome sequence of the prototype strain, which was isolated in 1953 to recently isolated strains and has provided evidence for genome stability for up to 50 years [Purkayastha et al, ; Mahadevan et al, ]. There have, however, been reports of recombination between hexon and fiber of HAdV‐B [Hierholzer & Pumarola, ; Adrian and Wigand, ; Hierholzer et al, ]. Intermediate strains of species B adenoviruses have been associated with outbreaks and more severe disease.…”

Section: Discussionmentioning

confidence: 99%

Genome stability of adenovirus types 3 and 7 during a simultaneous outbreak in Greater Manchester, UK

2014

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A total of 96 isolates of species B adenovirus collected in Greater Manchester, UK and typed previously by serum neutralization were analyzed in five genome regions. Of these, 62 isolates were HAdV-B3 and HAdV-B7 collected during a simultaneous 15 months outbreak. The rest of the isolates were HAdV-B types 3 and 7 and other species B adenovirus types collected in different years following the outbreak. The phylogenetic analysis results of all the isolates in the structural regions hexon L2, penton, and fiber knob were found to be consistent and no mismatches were observed. Most of the isolates in the DNA polymerase and E1A regions had the same clustering patterns as the structural regions. However, one HAdV-B7 and one HAdV-B11 isolate changed their clustering patterns in the DNA polymerase region. In addition, HAdV-B16 isolates changed their clustering patterns in both DNA polymerase and E1A regions. The changes of the clustering patterns of some isolates is more likely related to natural variations rather than recombination which indicate that species B adenovirus genome is stable even when different types are circulating in a limited geographical area simultaneously.

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Antigenic characterization of intermediate adenovirus 14-11 strains associated with upper respiratory illness in a military camp

Cited by 41 publications

References 19 publications

Adenovirus: Epidemiology, Global Spread of Novel Serotypes, and Advances in Treatment and Prevention

Adenovirus: Epidemiology, Global Spread of Novel Serotypes, and Advances in Treatment and Prevention

PCR and Restriction Endonuclease Analysis for Rapid Identification of Human Adenovirus Subgenera

Genome stability of adenovirus types 3 and 7 during a simultaneous outbreak in Greater Manchester, UK

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