Antigenic Analysis of Acute Hemorrhagic Conjunctivitis Viruses (Enterovirus Type 70)

Nucleotide sequences of the genome of enterovirus 70(EV70) isolated in Osaka in 1993 were determined, and compared with those of the past epidemic strains. Nucleotide substitution rates in 332 bp, 174 bp, and 178by of the genes encoding viral protein (VP)1, VP2, or VP3 were 9.0, 7.5, and5.6% between Kumoi-2/93 andJ670/71, respectively. Likewise, the putative amino acid substitution rates were 1.8, 0, and 0%. It seems that the epidemic strains ofEV70 in Japan have been evolving at a constant high nucleotide substitution rate but almost all the substitutions were synonymous.

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Antigenic Analysis of Acute Hemorrhagic Conjunctivitis Viruses (Enterovirus Type 70)

Cited by 5 publications

References 15 publications

Enteroviral conjunctivitis and its neurological complications

Enteroviral conjunctivitis and its neurological complications

Evolution of enterovirus type 70: Oligonucleotide mapping analysis of RNA genome

Nucleotide Sequence Analysis of Recent Epidemic Strains of Enterovirus 70

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