Antigenic alterations in tumors of epidermal origin

Tosca, Androniki; Varelzidis, A.; Nicolis, G.; Hadzis, J.; Stratigos, J.; Capetanakis, J.

doi:10.1002/1097-0142(19800501)45:9<2284::aid-cncr2820450911>3.0.co;2-s

Cited by 20 publications

(11 citation statements)

References 7 publications

(1 reference statement)

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“…The present work shows that, with simple immunoenzyme technology evaluating antibodies against EMA, T.K. and LM, we can further differentiate SCCs from BCCs by their antigenic behavior in addition to previously described characteristics (6)(7)(8) and to further support laboratory diagnosis.…”

Section: Discussionmentioning

confidence: 58%

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Antigenic Differences and Further Perspectives on the Differential Diagnosis of Skin Tumors

Tosca

Lehou

Παναγιωτόπουλος

et al. 1986

The Journal of Dermatology

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Frozen sections from squamous cell carcinomas (SCCs), basal cell carcinomas (BCCs), precancerous lesions (P.C.) and normal skin adjacent to lesions (N.S.) were studied by indirect immunoperoxidase for the detection of epithelial membrane antigen (EMA) and by PAP (peroxidase‐antiperoxidase) for total keratin (T.K.) and laminin (LM) to determine the significance of the appearance of neoantigens and the behavior of normal epidermal antigens during the process of carcinogenesis of the skin. Significant antigenic differences in all three antigens were revealed between SCCs and BCCs in the epidermis (EP) and tumor islands (T.I.). There were also significant differences in total keratin and laminin between SCC's and N.S. epidermis. SCCs did not show any significant differences in EMA from P.C. lesions, but T.K. was lower in P.C. lesions than in normal skin.

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Section: Discussionmentioning

confidence: 58%

“…It may also be found in squamous tumor lobules even when the epithelium is unreactive. We, therefore, thought that it might be interesting to study how these three antigens behave in skin tumors in an attempt to extend the previous characterization of SCCs and BCCs (6)(7)(8).…”

Section: Introductionmentioning

confidence: 99%

Antigenic Differences and Further Perspectives on the Differential Diagnosis of Skin Tumors

Tosca

Lehou

Παναγιωτόπουλος

et al. 1986

The Journal of Dermatology

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“…The BCC’s basal lamina has been an issue to discuss even since the 1980s (and, indirectly, has also been the BCC clefting). 22 The basement membrane is a thin layer of extracellular matrix underlying epithelial cells, separating them from and also connecting them to the stroma or interstitial matrix. 23 In 1980, Tosca et al concluded that basement membrane antigenic loss (meaning the bullous pemphigoid antigen) is a general and early trait of neoplasia, being directly linked to the characteristic neoplastic cell’s loss of control, making it able to further disseminate and metastasize.…”

Section: Then…mentioning

confidence: 99%

“… 23 In 1980, Tosca et al concluded that basement membrane antigenic loss (meaning the bullous pemphigoid antigen) is a general and early trait of neoplasia, being directly linked to the characteristic neoplastic cell’s loss of control, making it able to further disseminate and metastasize. 22 …”

Section: Then…mentioning

confidence: 99%

“…Other epidermal tumors, such as benign ones (trichoepithelioma, wart, seborrheic keratosis, cylindroma) or malignancies (squamous cell carcinoma – keratoacanthoma-like, superficially invasive or invasive one), do not have this particular trait, presenting all three antigens in their basal lamina which surrounds the epithelial tumor nests, as well as in the normal epidermis. 22 , 24 …”

Section: Then…mentioning

confidence: 99%

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Multimodal Considerations Concerning Basal Cell Carcinoma Clefting – Profile of Structural and Aggressive Traits – Perspectives

Niculeț¹,

Bobeică²,

Crăescu³

et al. 2022

CCID

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Although basal cell carcinoma is a well-known tumor with confirmed clinical and histopathology traits, prognosis factors and treatment options, new facets of this tumor emerge as innovative approach methods develop. Reflectance confocal microscopy (RCM) and optical coherence tomography (OCT) allow a basal cell carcinoma’s in vivo analysis of its depth of invasion, tumor margins prior to surgical approach and the tumor’s response to a non-invasive treatment, evaluating simultaneously the tumor’s vasculature. By RCM and OCT analysis, basal cell carcinoma has registered a groundbreaking discovery regarding a small (but with predictive factor potential) trait – the cleft, developing in between the tumor islands/nodules/chords and the surrounding tumor stroma; it was considered to date as a consequence of the tissue’s histopathology processing. RCM and OCT revealed that the “clefting artifact”, as it is frequently found in the medical literature, is not actually an artifact of laboratory processing, but a tumor trait found in vivo, with apparent mucin deposits. This review aims at merging the methods of evaluating basal cell carcinoma, both non-invasive (dermoscopy, RCM, OCT) and invasive ones (histopathology – with newly proposed classification), with special emphasis on the cleft issue – its assessment with the aforementioned techniques, with potential implications in the patient’s prognosis.

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A specific antigenic defect of the basement membrane is found in basal cell carcinoma but not in other epidermal tumors

Stanley

Beckwith

Fuller

et al. 1982

Cancer

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The basement membrane of basal cell carcinoma was characterized by indirect immunofluorescence using antibodies to laminin, type IV collagen, and bullous pemphigoid antigen, three distinct protein components of basement membrane. Aggregates of basal cell carcinoma in the dermis were surrounded by a continuous basement membrane containing laminin and type IV collagen; however, bullous pemphigoid antigen was either completely undetectable or faint and discontinuous rather than linear. In contrast to this specific defect in bullous pemphigoid antigen found in basal cell carcinoma, well‐differentiated superficially invasive epidermal squamous cell carcinoma and several benign epidermal tumors (trichoepithelioma, wart, keratoacanthoma, seborrheic keratosis, cylindroma) displayed all three antigens in the basement membrane that surrounded epithelial cell aggregates. Cylindroma displayed, in addition, broad areas of type IV collagen in the hyalinized material between epithelial islands. Basal cell carcinoma was the only tumor examined in which there was a specific antigenic defect in the basement membrane. This defect in bullous pemphigoid antigen may be due to abnormal synthesis by the tumor cells and could be related to the absence of differentiation of these cells.

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Antigenic alterations in tumors of epidermal origin

Cited by 20 publications

References 7 publications

Antigenic Differences and Further Perspectives on the Differential Diagnosis of Skin Tumors

Antigenic Differences and Further Perspectives on the Differential Diagnosis of Skin Tumors

Multimodal Considerations Concerning Basal Cell Carcinoma Clefting – Profile of Structural and Aggressive Traits – Perspectives

A specific antigenic defect of the basement membrane is found in basal cell carcinoma but not in other epidermal tumors

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