Antigen uptake and immunoglobulin production in Atlantic cod (Gadus morhua L.) after intraperitoneal injection of Vibrio anguillarum

Arnesen, S. M.; Schrøder, Merete Bjørgan; Dalmo, Roy Ambli; Bøgwald, Jarl

doi:10.1006/fsim.2001.0390

Cited by 25 publications

(16 citation statements)

References 22 publications

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“…(Ferguson et al 1982;Stensvåg et al 1999) or i.p. (Arnesen et al 2002;Grove et al 2003) being accompanied or not accompanied by a higher number of Ig-producing cells compared with control fish. However, the above studies do not identify the cells involved in antigen capture, transport and presentation, mainly because of the lack of specific markers for the different leucocyte populations of fish.…”

Section: Discussionmentioning

confidence: 83%

“…At the same time, the HK also serves as a secondary lymphoid organ (a lymph node analogue) in the induction and elaboration of immune responses (Kaattari and Irwin 1985) and in the clearance of soluble (Stensvåg et al 1999) and particulate (Ferguson et al 1982) antigen from the bloodstream. The spleen of teleosts has also been implicated in the clearance of blood-borne substances and immune complexes in specialised terminations of arterioles, called ellipsoids (Espenes et al 1995(Espenes et al , 1997Arnesen et al 2002).…”

Section: Introductionmentioning

confidence: 99%

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Early innate immune response and redistribution of inflammatory cells in the bony fish gilthead seabream experimentally infected with Vibrio anguillarum

et al. 2005

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An obvious difference between the immune system of fish and mammals is that fish lack both bone marrow and lymph nodes; in their place, the head-kidney acts as a major haematopoietic and lymphoid organ in adult fish, whereas the thymus, spleen and mucosa-associated lymphoid tissues are common to both fish and mammals. This suggests that differences exist in antigen presentation and naive lymphocyte stimulation, a prerequisite for the initiation of adaptive immune responses. Intraperitoneal injection of the bony fish gilthead seabream (Sparus aurata L.) with intact Vibrio anguillarum, as a particulate bacterial antigen, results in the mobilisation of head-kidney leucocytes to the peritoneal cavity and priming of their respiratory burst activity. We have also observed the rapid infiltration of acidophilic granulocytes, which are leucocytes functionally equivalent to mammalian neutrophils, into the spleen. These cells may be involved in antigen capture and transport to the spleen, since an apparent association between mobilised acidophilic granulocytes, bacterial antigens and proliferating lymphocytes has been seen in this organ. Collectively, these results suggest that, in addition to being actively involved in bacterial clearance, fish phagocytic granulocytes play a role in the initiation and support of the adaptive immune response.

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Section: Discussionmentioning

confidence: 83%

Section: Introductionmentioning

confidence: 99%

Early innate immune response and redistribution of inflammatory cells in the bony fish gilthead seabream experimentally infected with Vibrio anguillarum

et al. 2005

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“…Stenvik et al [18] found evenly scattered B-cells throughout both the HK and spleen of cod, in contrast to Atlantic salmon [26] and turbot (Scopthalmus maximus L.) [42], where B-cells were more clustered. Arnesen et al [20] Fig. 3 (continued ) observed no difference in the distribution of the Ig-synthesizing cells in HK or spleen when comparing immunised and non-immunised Atlantic cod.…”

Section: Discussionmentioning

confidence: 88%

“…On the other hand, Nikoskelainen et al [31] showed that the respiratory burst activity in cod blood was at least twice that of trout. No co-localisation of antigen-containing and antibody-producing cells has been observed in either HK or spleen in cod, though some degree of organisation of antigen uptake and plasma cells has been observed in the spleen [20].…”

Section: Introductionmentioning

confidence: 97%

“…Cod has about 10 times higher concentrations of IgM in plasma compared to salmon [2], and the low or absent rise in antibodies after immunisation [1,3,4] and also a lack of rise in the number of antibody-producing cells after antigen stimulation [20], have led to intensive studies on the cod Ig. The cod Ig has been shown to differ from that of salmon both in the IgM isotype organisation and structure as well as in the organisation and repertoire of Ig genes [21,22], although it is difficult to relate these findings to biological functions.…”

Section: Introductionmentioning

confidence: 99%

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Neutrophils and B-cells in Atlantic cod (Gadus morhua L.)

Rønneseth

Wergeland

Pettersen

2007

Fish & Shellfish Immunology

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Uptake of Foreign Ferritin in Heart of Firemouth Cichlid (Cichlidae: Teleostei)

Leknes

2011

The Anatomical Record

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The ultrastructure of the endothelium in the heart of the firemouth cichlid (Thorichthys meeki) and its capability and capacity to take up foreign ferritin are described. The entire wall in atrium and ventricle was spongy and composed of muscle trabeculae, covered by endothelial cells which were about 4-6-lm thick in atrium and flat in ventricle. These cells contained a number of moderately electron-dense bodies (MDBs, diameter 2 lm and less), clathrin-coated vesicles, and tubules of agranular endoplasmatic reticulum. Numerous yellow-brown granules, width 2 lm and less, occurred in the endocardial endothelium covering the cardiac muscle trabeculae in ferritin-injected firemouth cichlid 8 hr postinjection; much Prussian blue precipitated within these granules when treated with acid ferrocyanide. When the time between the injection and sacrifice was extended to 24 hr, the granules and Prussian blue precipitations in the corresponding endocardial endothelium displayed a width of 3 lm and more. The endocardial endothelium facing the cardiac main lumen or covering the valves and walls of the atrio-ventriclar or ventriculo-bulbar apertures nearly lacks such granules and precipitations as well as MDB, clathrin-coated vesicles and tubules of agranular endoplasmic reticulum, suggesting that the endothelium at these sites is not endocytic. Lipofuscinlike pigments were demonstrated by the Schmorl's technique in the endocardial endothelium covering the heart muscle trabeculae in firemouth cichlid. Together these findings suggest that the endocardial endothelium cover on the muscle trabeculae in heart wall in firemouth cichlid is highly specialized to play important roles in the uptake of scavenger molecules and foreign particles. Such an uptake may be very efficient as this cell layer comes in contact with nearly the entire blood volume throughout the spongy heart wall in this type of teleosts. Anat Rec, 294:1500Rec, 294: -1505Rec, 294: , 2011. V V C 2011 Wiley-Liss, Inc.

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Antigen uptake and immunoglobulin production in Atlantic cod (Gadus morhua L.) after intraperitoneal injection of Vibrio anguillarum

Cited by 25 publications

References 22 publications

Early innate immune response and redistribution of inflammatory cells in the bony fish gilthead seabream experimentally infected with Vibrio anguillarum

Early innate immune response and redistribution of inflammatory cells in the bony fish gilthead seabream experimentally infected with Vibrio anguillarum

Neutrophils and B-cells in Atlantic cod (Gadus morhua L.)

Uptake of Foreign Ferritin in Heart of Firemouth Cichlid (Cichlidae: Teleostei)

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