Antigen Structure and Lymphocyte Activation

Goodman, Joel W.; Fong, Sherman; Lewis, George K.; Kamin, Roberta M.; Nitecki, Danute E.; Balian, Georges Der

doi:10.1111/j.1600-065x.1978.tb00396.x

Cited by 28 publications

(20 citation statements)

References 34 publications

(31 reference statements)

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“…This area has been reviewed by Bullock [,210] and later studies reported by Alkan [211]. A further aspect of this work is the ability of APA-tyrosine when linked to a chemical group acting as a hapten such as dinitrophenyl, DNP, to act as a carrier [212]. In this case a DH reaction due to the APA was observed together with antibody production for the DNP.…”

Section: Arsenic and The Immune Systemmentioning

confidence: 85%

“…In this case a DH reaction due to the APA was observed together with antibody production for the DNP. Work on this in relation to lymphocyte activation has been reviewed by Goodman et al [212]. In azophenylarsonate and its protein conjugates, As is in the + 5 oxidation state and all the reported work assumes that the species is unchanged in vivo.…”

Section: Arsenic and The Immune Systemmentioning

confidence: 95%

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The structure and reactivity of arsenic compounds: Biological activity and drug design

Dhubhghaill

Sadler

1991

Structure and Bonding

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Section: Arsenic and The Immune Systemmentioning

confidence: 85%

Section: Arsenic and The Immune Systemmentioning

confidence: 95%

The structure and reactivity of arsenic compounds: Biological activity and drug design

Dhubhghaill

Sadler

1991

Structure and Bonding

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“…Thus, at times, in studying the potential functional capabilities of T cell populations, one views only the composite function of T cells with various receptor specificities and activities. helper T cells [7]. These observations are strengthened by evidence from several laboratories which argues strongly that the T cell receptor is composed, in part, of the immunoglobulin (Ig) variable regions [8,91.…”

Section: Introductionmentioning

confidence: 91%

Multiple B cell stimulation by individual antigen‐specific T lymphocytes

Pierce,

Klinman

1981

Eur J Immunol

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Recently, an experimental system has been described which allows for the isolation and antigenic stimulation of individual antigen-specific helper T lymphocytes in collaboration with a nonlimiting number of primary B lymphocytes. In the studies presented in this report, this system has been employed to determine whether an individual T lymphocyte has the potential to interact with more than a single B lymphocyte, when the B cells are of different antigenic specificities. The results of these studies indicate that an individual influenza virus PR 8-specific T lymphocyte has the ability to promote antibody responses of both trinitrophenyl (TNP)- and PR8-specific B lymphocytes in response to the in vitro antigen TNP-PR8. Similar results were obtained when T cells specific for the hapten TNP were used in collaboration with TNP- and PR8-specific B cells. These results demonstrate that an individual T lymphocyte has the potential to collaborate with more than one B lymphocyte, and that these B cells may differ in their antibody receptor for antigen. These results do not rule out a role for idiotype or allotype-specific T cells in antibody responses but, rather, strongly argue that antigen-specific T cells are able to independently initiate primary B cell responses of B cells with distinct antibody receptors. In addition, under these conditions, hapten-specific helper T cells can be readily demonstrated and may facilitate the response of B cells specific for the same or different determinants.

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“…It has been well accepted that the helper/inducer cell and the effector B cell (the precursor of the antibody-producing cell) combine with different topographic regions of the complexed antigen [19,45,52,54]. The B cell combines with 'haptenic' determinants, whereas the helper/inducer T cell combines with the 'carrier' determinants of the antigen ('linked recognition') [45,52].…”

Section: Coexistence Of Antagonistic Immunoreactive Epitopes In Variomentioning

confidence: 99%

Coexistence of immunogenic and suppressogenic epitopes in tumor cells and various types of macromolecules

Naor

1983

Cancer Immunol Immunother

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Antigen Structure and Lymphocyte Activation

Cited by 28 publications

References 34 publications

The structure and reactivity of arsenic compounds: Biological activity and drug design

The structure and reactivity of arsenic compounds: Biological activity and drug design

Multiple B cell stimulation by individual antigen‐specific T lymphocytes

Coexistence of immunogenic and suppressogenic epitopes in tumor cells and various types of macromolecules

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