Antigen-specific suppression of cultured lymphocytes from patients with neurocysticercosis

Bueno, Ednéia Casagranda; Vaz, Adelaide José; Machado, L. R.; Livramento, José Antônio; Avila, Sandra; Ferreira, Antônio Walter

doi:10.1046/j.1365-2249.2001.01579.x

Cited by 19 publications

(17 citation statements)

References 23 publications

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“…This Wnding was consistent with the previously reported signiWcant association between severe neurocysticercosis and a decrease in the proliferative cell response [10,18]. This result points to a tight relation between local and systemic immunity elicited against the parasitosis, reXected in the presence of anti-inXammatory cytokines in CNS that could act as modulators of the CNS damage caused by neuroinXammation.…”

Section: Discussionsupporting

confidence: 92%

“…Considering the relevance of neuroinXammation in NC pathogenesis, increased eVorts have been performed to characterize the immune-inXammatory response in NC and its role in dealing with the parasite [9][10][11][12][13][14][15][16][17]. All studies have been performed studying the CSF (local) or blood (peripheral) of NC patients independently.…”

Section: Introductionmentioning

confidence: 99%

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Neurocysticercosis: local and systemic immune-inflammatory features related to severity

Sáenz¹,

Fleury²,

Chavarría³

et al. 2011

Med Microbiol Immunol

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Neurocysticercosis (NC) is caused by the establishment of Taenia solium cysticerci in the central nervous system. Previous studies have established that neuroinflammation plays a key role in the severity of the disease. However, the relationship between peripheral and local immune response remains inconclusive. This work studies the peripheral and local immune-inflammatory features and their relationships, toward the identification of potential peripheral immunologic features related to severity. A panel of cytokines was measured in paired cerebrospinal fluid (CSF) and in the supernatant of antigen-specific stimulated peripheral blood mononuclear cells samples (SN) in a total of 31 untreated inflammatory and non-inflammatory NC patients. Increased clinical and radiologic severity was associated with an increased cerebrospinal fluid cell count. A peripheral proliferative depression that negatively correlates with CSF cellularity and TNFα and that positively correlates with SN IL5 was observed in severe NC patients. These results provide evidences to support the systemic proliferative response as a biomarker to monitor the level of neuroinflammation, of possible value in the patients' follow-up during treatment.

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Section: Discussionsupporting

confidence: 92%

Section: Introductionmentioning

confidence: 99%

Neurocysticercosis: local and systemic immune-inflammatory features related to severity

Sáenz¹,

Fleury²,

Chavarría³

et al. 2011

Med Microbiol Immunol

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“…A study from our group using a lymphoproliferation assay with T. solium and T. crassiceps antigens as stimuli showed an antigen-specific suppression in NC-patients, suggesting that the antigenic components play a suppressor role in the host immune response 10 .…”

mentioning

confidence: 88%

Cysticercosis and the immunossupression: what are the mechanisms involved?

Bueno

2012

Arq. Neuro-Psiquiatr.

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“…Moreover, decreased proliferation of splenic lymphocytes from mice infected with Taenia crassiceps and peripheral lymphocytes from cysticercotic humans stimulated with Con-A or cysticercal antigens have been reported (Sciutto et al, 1995;Bueno et al, 2001). Little information about the parasitic molecules involved in the induction of immune suppressive effects is available.…”

Section: Introductionmentioning

confidence: 99%

ATaenia crassicepsfactor induces apoptosis of spleen CD4+T cells and TFG-β andFoxp3gene expression in mice

et al. 2015

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This study was undertaken to determine whether a parasite substance produces structural pathology in the mouse spleen. A low-molecular-weight Taenia crassiceps metacestode factor (MF) isolated from the peritoneal fluid of female mice infected with T. crassiceps metacestodes induced pathological and immunological changes in mouse spleen cells in vivo. Electron microscopy and confocal microscopy revealed severe changes in the spleen histoarchitecture of T. crassiceps-infected and MF-treated mice. Apoptotic degenerated spleen cells were observed in the white and red pulps and were more conspicuous in the white pulp of the spleen from the T. crassiceps-infected mice than in that of the MF-treated mice. Flow cytometry analysis revealed that the numbers of spleen CD4+T cells were significantly lower in both experimental groups than in control mice. The ex vivo expression of transforming growth factor (TGF)-β and factor Foxp3 were significantly higher in splenocytes of the experimental mice than the basal expression observed in the control cells. These findings may have potential applications for a better understanding of the host-parasite relationship in human neurocysticercosis.

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Antigen-specific suppression of cultured lymphocytes from patients with neurocysticercosis

Cited by 19 publications

References 23 publications

Neurocysticercosis: local and systemic immune-inflammatory features related to severity

Neurocysticercosis: local and systemic immune-inflammatory features related to severity

Cysticercosis and the immunossupression: what are the mechanisms involved?

ATaenia crassicepsfactor induces apoptosis of spleen CD4+T cells and TFG-β andFoxp3gene expression in mice

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