Antigen-specific regulatory T cells are detected in Peyer's patches after the interaction between T cells and dendritic cells loaded with orally administered antigen

Nagatani, Katsuya; Komagata, Yoshinori; Asako, Kurumi; Takayama, Maki; Yamamoto, Kazuhiko

doi:10.1016/j.imbio.2010.06.008

Cited by 8 publications

(9 citation statements)

References 26 publications

(33 reference statements)

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“…The discovery of microfold ('M') cells in Peyer's patches and their ability to transport antigen into the immune system 41 led to the assumption that this would be the route for inducing oral tolerance. Indeed, the first formal demonstration of 'suppressor T cells' in oral tolerance described these cells in Peyer's patches 42 , while both clonal deletion of antigen-specific T cells and CD4 + T cells with inhibitory properties were subsequently described in the Peyer's patches of protein-fed mice 8,43 . Nevertheless a number of studies have shown that surgical or developmental removal of Peyer's patches does not alter the induction of oral tolerance to proteins (see 44 for review) and in recent years, attention has turned more to the idea that the relevant antigen is acquired by DCs in the villus lamina propria and transported by these cells to the draining MLNs where the induction of Treg cells occurs ( Figure 2).…”

Section: Dcs and Intestinal Tolerancementioning

confidence: 99%

To respond or not to respond — a personal perspective of intestinal tolerance

2018

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For many years, the intestine was one of the poor relations of the immunology world, being a realm inhabited mostly by specialists and those interested in unusual phenomena. However, this has changed dramatically in recent years with the realization of how important the microbiota is in shaping immune function throughout the body, and almost every major immunology institution now includes the intestine as an area of interest. One of the most important aspects of the intestinal immune system is how it discriminates carefully between harmless and harmful antigens, in particular, its ability to generate active tolerance to materials such as commensal bacteria and food proteins. This phenomenon has been recognized for more than 100 years, and it is essential for preventing inflammatory disease in the intestine, but its basis remains enigmatic. Here, I discuss the progress that has been made in understanding oral tolerance during my 40 years in the field and highlight the topics that will be the focus of future research.

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Section: Dcs and Intestinal Tolerancementioning

confidence: 99%

To respond or not to respond — a personal perspective of intestinal tolerance

2018

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“…This is not unexpected, as antigen-loaded CD11b þ DC are able to induce T-cell differentiation, and differentiation of CD4 þ T cells into Treg in particular. [33][34][35] This process results in oral tolerance to bacterial and other antigens. Furthermore, a decrease in B cells after smoke exposure was observed, but without an accompanying change in luminal IgA production.…”

Section: Smoking Alters Intestinal Apoptosis and Galtmentioning

confidence: 99%

Cigarette smoking alters epithelial apoptosis and immune composition in murine GALT

Verschuere

Bracke

Demoor

et al. 2011

Laboratory Investigation

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Smokers have a twofold increased risk to develop Crohn's disease (CD). However, little is known about the mechanisms through which smoking affects CD pathogenesis. Especially Crohn's ileitis is negatively influenced by smoking. Interestingly, the ileum and, more in particular, the Peyer's patches in the terminal ileum are also the sites where the first CD lesions are found. Several chemokines are implicated in the pathogenesis, among which is the CCL20-CCR6 pathway. Here, we studied the gut-associated lymphoid tissue in C57BL/6 wild-type mice and in CCR6-deficient mice after exposure to air or cigarette smoke for 24 weeks. Apoptotic index of the follicle-associated epithelium overlying the Peyer's patches was evaluated. We found that chronic smoke exposure induced apoptosis in the follicle-associated epithelium. Furthermore, immune cell numbers and differentiation along with chemokine expression were determined in Peyer's patches. Important changes in immune cell composition were observed: total dendritic cells, CD4 þ T cells (including regulatory T cells) and CD8 þ T cells increased significantly after smoke exposure. The CD11b þ dendritic cell subset almost doubled. Interestingly, these changes were accompanied by an upregulated mRNA expression of the chemokines CCL9 and CCL20. However, no differences in the increase of dendritic cells were observed between wild-type and CCR6-deficient mice. Our results show that cigarette smoke exposure increases apoptosis in the follicle-associated epithelium and is associated with immune cell accumulation in Peyer's patches.

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“…Instead, iTreg could be especially important for generating tolerance to orally delivered antigens with even more diverse and “fluctuating” antigen repertoire. This view is supported by OVA feeding experiments, as described above as well as the study by Nagatani et al (53) indicating that adoptively transferred OVA-specific naïve T cells in Peyer’s patches (PP) start to express Foxp3 after oral administration of ovalbumin.…”

Section: Treg Cells In the Gutmentioning

confidence: 62%

Regulatory T Cells Control Immune Responses through Their Non-Redundant Tissue Specific Features

Lehtimäki

Lahesmaa

2013

Front. Immunol.

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Regulatory T cells (Treg) are needed in the control of immune responses and to maintain immune homeostasis. Of this subtype of regulatory lymphocytes, the most potent are Foxp3 expressing CD4+ T cells, which can be roughly divided into two main groups; natural Treg cells (nTreg), developing in the thymus, and induced or adaptive Treg cells (iTreg), developing in the periphery from naïve, conventional T cells. Both nTreg cells and iTreg cells have their own, non-redundant roles in the immune system, with nTreg cells mainly maintaining tolerance toward self-structures, and iTreg developing in response to externally delivered antigens or commensal microbes. In addition, Treg cells acquire tissue specific features and are adapted to function in the tissue they reside. This review will focus on some specific features of Treg cells in different compartments of the body.

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Antigen-specific regulatory T cells are detected in Peyer's patches after the interaction between T cells and dendritic cells loaded with orally administered antigen

Cited by 8 publications

References 26 publications

To respond or not to respond — a personal perspective of intestinal tolerance

To respond or not to respond — a personal perspective of intestinal tolerance

Cigarette smoking alters epithelial apoptosis and immune composition in murine GALT

Regulatory T Cells Control Immune Responses through Their Non-Redundant Tissue Specific Features

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