Antigen-specific IgE in middle ear effusion of patients with eosinophilic otitis media

Kanazawa, Hiromi; Yoshida, Naohiro; Shinnabe, Akihiro; Iino, Yukiko

doi:10.1016/j.anai.2014.04.021

Cited by 23 publications

(12 citation statements)

References 22 publications

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“…In patients with EOM, 62% of patients (62%) versus 11% of control patients (11%) had antigen-specific IgE in the middle ear effusion although no difference was noted in the total serum IgE concentrations [ 23 ]. The severity score of EOM in the antigen-specific IgE-positive group was significantly higher than that in the antigen-specific IgE-negative group suggesting that antigen-specific IgE against inhalant and bacterial antigens may be locally produced in the middle ear mucosa in patients with EOM.…”

Section: Eosinophilic Otitis Media (Eom)mentioning

confidence: 99%

See 1 more Smart Citation

Otitis media with effusion and atopy: is there a causal relationship?

Zernotti

Pawankar

Ansotegui

et al. 2017

World Allergy Organization Journal

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Otitis Media with Effusion (OME) is an inflammatory condition of the middle ear cleft, acute or chronic, with collection of fluid in the middle ear with an intact tympanic membrane. It is a very common disease in childhood, the most frequent cause of hearing loss in childhood and often requiring surgery. OME is called chronic when the fluid in the middle ear persists for more than three months or when the episodes recur six or more times in one year. The current article covers various aspects of OME including definition, epidemiology. Pathomechanisms, risk factors, role of allergy in OME, impact of upper airway disease on OME, eosinophilic otitis media and management of OME.

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Section: Eosinophilic Otitis Media (Eom)mentioning

confidence: 99%

“…One or more antigen-specific IgE antibodies were detected in middle ear effusion of 16 out of 26 patients (62%) with a higher severity score of EOM. Sensitization to fungi and Staphylococcus aureus in particular was observed [ 86 ].…”

Section: Role Of Allergy – Ige-mediated Inflammation In the Developmementioning

confidence: 99%

Otitis media with effusion and atopy: is there a causal relationship?

Zernotti

Pawankar

Ansotegui

et al. 2017

World Allergy Organization Journal

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“…Therefore, EOM is an allergic-type disease not related to vasculitis. 62 The clinical features of EOM resemble localized EGPA. During treatment for EOM, some patients presented numbness in the leg or skin eruptions characteristic of EGPA.…”

Section: Relationship Between Egpa and Omaavmentioning

confidence: 99%

Pathogenesis and Diagnosis of Otitis Media with ANCA-Associated Vasculitis

Yoshida

Iino

2014

Allergology International

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Antineutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV) is histologically characterized by systemic necrotizing vasculitis and is clinically classified into two phases, systemic or localized. Recently, otological symptoms such as otitis media and hearing loss, not previously often associated with AAV, have been reported in AAV cases. In these cases we propose a diagnosis of otitis media with AAV (OMAAV). The ANCA titer is important for the diagnosis of OMAAV, and in most cases rapid progressive hearing loss is observed as localized AAV. Peripheral facial nerve palsy or hypertrophic pachymeningitis are coupled with 25% of cases and 18% of cases respectively. Proteinase 3-ANCA (PR3-ANCA) positive otitis media causes granulomatous formation or middle ear effusion in the middle ear, on the other hand myeloperoxidase-ANCA (MPO-ANCA) positive otitis media predominantly presents as otitis media with effusion. The early diagnosed case and the sensorineural hearing loss not progressed deaf could be recovered by the immunosuppressive therapy. Delayed diagnosis of AAV occasionally leads to progression to the irreversible phase; therefore, diagnosis at the early-localized stage is important for treating AAV. In this review, we discuss the current understanding of this newly proposed concept of OMAAV.

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“…Iino et al [ 20 ] reported that patients with EOM tended to have patulous eustachian tube function, which allows inflammatory substances in the upper airway to penetrate the middle ear cavity more easily than observed in patients with normal eustachian tube function. Kanazawa et al [ 21 ] reported that fungus-specific IgE and Staphylococcus aureus enterotoxin-specific IgE were found in the middle ear effusion of patients with EOM. Because antigens such as fungus and S. aureus are also found in upper airway like nasal cavity, it seems reasonable to consider those antigens penetrate middle ear cavity via eustachian tube.…”

Section: Discussionmentioning

confidence: 99%

CD11c(+) dendritic cells coexpressing thymic stromal lymphopoietin receptor in animal model of eosinophilic otitis media

Hara

Kudo

Suzuki

et al. 2020

Asia Pacific Allergy

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Background: Eosinophilic otitis media (EOM) is an intractable middle ear disease often associated with eosinophilic inflammatory airway conditions. Recently, dendritic cells (DCs) have been indicated as an essential component of Th2 allergic inflammation, such as bronchial asthma. DCs are activated by thymic stromal lymphopoietin (TSLP), an epithelial cell-derived cytokine. However, the relationship between TSLP and DCs in EOM remains unknown. Objective: This study aimed to investigate the relationship between DCs and TSLP and to determine the involvement of DCs in EOM in an animal model. Methods: Hartley guinea pigs were used as the animal model. Daily ovalbumin (OVA) stimulation of the middle ear was performed for 7 or 14 days. The temporal bone was dissected on the last day of stimulation, and paraffin-embedded sections were prepared. Immunostaining and immunofluorostaining for TSLP receptor (TSLPR) and CD11c, a surface marker of DCs, were performed. Results: We found CD11c-immunopositive cells in the submucosal area of the middle ear epithelium, particularly around the eustachian tube. TSLPR-immunopositive cells exhibited a similar distribution as CD11c-positive cells. Conclusion: CD11c positive DCs coexpressing TSLPR were recruited after OVA challenge which might activate Th2 allergic reaction.

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Antigen-specific IgE in middle ear effusion of patients with eosinophilic otitis media

Cited by 23 publications

References 22 publications

Otitis media with effusion and atopy: is there a causal relationship?

Otitis media with effusion and atopy: is there a causal relationship?

Pathogenesis and Diagnosis of Otitis Media with ANCA-Associated Vasculitis

CD11c(+) dendritic cells coexpressing thymic stromal lymphopoietin receptor in animal model of eosinophilic otitis media

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