Antigen specific and nonspecific modulation of the immune response by aminolevulinic acid based photodynamic therapy

Hryhorenko, Eric A.; Oseroff, Allan R.; Morgan, Janet; Rittenhouse-Diakun, Kate

doi:10.1016/s0162-3109(98)00047-2

Cited by 28 publications

(17 citation statements)

References 27 publications

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“…Therefore, selectivity of PDT mainly results from the fact that illumination itself limits the area that is being damaged and includes tumour cells, tumour stroma (including vasculature and fibroblasts) and tumour infiltrating cells of the immune system. Numerous studies have documented that photosensitisers efficiently accumulate in normal human lymphocytes [105,106]. However, resting lymphocytes only poorly accumulate photosensitisers, and the uptake is improved in activated cells [106][107][108].…”

Section: Pdt and Its Effects On Immune Systemmentioning

confidence: 99%

Photodynamic therapy: illuminating the road from cell death towards anti-tumour immunity

et al. 2010

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Photodynamic therapy (PDT) utilizes the destructive power of reactive oxygen species generated via visible light irradiation of a photosensitive dye accumulated in the cancerous tissue/cells, to bring about their obliteration. PDT activates multiple signalling pathways in cancer cells, which could give rise to all three cell death modalities (at least in vitro). Simultaneously, PDT is capable of eliciting various effects in the tumour microenvironment thereby affecting the tumour-associated/-infiltrating immune cells and by extension, leading to infiltration of various immune cells (e.g. neutrophils) into the treated site. PDT is also associated to the activation of different immune phenomena, e.g. acute-phase response, complement cascade and production of cytokines/chemokines. It has also come to light that, PDT is capable of activating 'anti-tumour adaptive immunity' in both pre-clinical as well as clinical settings. Although the ability of PDT to induce 'anti-cancer vaccine effect' is still debatable, yet it has been shown to be capable of inducing exposure/release of certain damage-associated molecular patterns (DAMPs) like HSP70. Therefore, it seems that PDT is unique among other approved therapeutic procedures in generating a microenvironment suitable for development of systemic anti-tumour immunity. Apart from this, recent times have seen the emergence of certain promising modalities based on PDT like-photoimmunotherapy and PDT-based cancer vaccines. This review mainly discusses the effects exerted by PDT on cancer cells, immune cells as well as tumour microenvironment in terms of anti-tumour immunity. The ability of PDT to expose/release DAMPs and the future perspectives of this paradigm have also been discussed.

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Section: Pdt and Its Effects On Immune Systemmentioning

confidence: 99%

Photodynamic therapy: illuminating the road from cell death towards anti-tumour immunity

et al. 2010

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“…Depending on the variables, PDT can alter the balance between stimulation or regulation of the immune response by the release of certain cytokines, expression of heat shock proteins or the release of antigens from the treated tissue [7] . The effect of PDT on epidermal Langerhans cells and antigen-presenting cells such as dendritic cells and macrophages has been reported [8,9] . We also found a decreased number of positive cells for CD3, CD4, CD8, CD68 and CD1a after PDT in the second case.…”

Section: Discussionmentioning

confidence: 99%

Treatment of Pigmented Purpuric Dermatosis with Topical Photodynamic Therapy

Kim¹,

Kim²,

Kim³

2009

Dermatology

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“…The excited species (especially triplet species) transfer energy to oxygen (type II photosensitisation), or undergo direct reaction (electron transfer or other reactions) with the target substrates (type I photosensitisation), usually generating radicals and finally ROS ( Figure 1) (11). In addition to causing cell death, photosensitisation reactions in biological tissues can also induce immune stimulatory reactions (12,13), and consequently have the potential to improve the overall host response to infections (3). However, under mild conditions, oxygen does not react with electron pairs of organic molecules in the ground state.…”

Section: Photosensitisers: Fundamentals and State Of The Artmentioning

confidence: 99%

Photodynamic antimicrobial chemotherapy (PACT) for the treatment of malaria, leishmaniasis and trypanosomiasis

Baptista

Wainwright

2011

Braz J Med Biol Res

102

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Antigen specific and nonspecific modulation of the immune response by aminolevulinic acid based photodynamic therapy

Cited by 28 publications

References 27 publications

Photodynamic therapy: illuminating the road from cell death towards anti-tumour immunity

Photodynamic therapy: illuminating the road from cell death towards anti-tumour immunity

Treatment of Pigmented Purpuric Dermatosis with Topical Photodynamic Therapy

Photodynamic antimicrobial chemotherapy (PACT) for the treatment of malaria, leishmaniasis and trypanosomiasis

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