2006
DOI: 10.1128/iai.74.3.1547-1554.2006
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Antigen-Responsive CD4+T Cells from C3H Mice Chronically Infected withLeishmania amazonensisAre Impaired in the Transition to an Effector Phenotype

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Cited by 22 publications
(14 citation statements)
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“…15 Our laboratory has shown that CD4 ϩ T cells from mice chronically infected with L. amazonensis are impaired in their ability to transition into an effector phenotype. 6 We propose that these differences in BMDC phenotype previously observed to be elicited by L. amazonensis promastigotes and amastigotes in vitro, would be reflected during in vivo infection as the infection progresses from peracute (2 days postinfection [dpi]) to acute (7 dpi). Mice were infected subcutaneously in the left footpad with L. amazonensis or L. major promastigotes and sacrificed at 2 and 7 dpi.…”
Section: In the Draining Lymph Node Of L Amazonensis-infected Micmentioning
confidence: 85%
See 1 more Smart Citation
“…15 Our laboratory has shown that CD4 ϩ T cells from mice chronically infected with L. amazonensis are impaired in their ability to transition into an effector phenotype. 6 We propose that these differences in BMDC phenotype previously observed to be elicited by L. amazonensis promastigotes and amastigotes in vitro, would be reflected during in vivo infection as the infection progresses from peracute (2 days postinfection [dpi]) to acute (7 dpi). Mice were infected subcutaneously in the left footpad with L. amazonensis or L. major promastigotes and sacrificed at 2 and 7 dpi.…”
Section: In the Draining Lymph Node Of L Amazonensis-infected Micmentioning
confidence: 85%
“…Alteration of surface marker expression, cytokine production, maturation, and function of DC following L. amazonensis infection has been previously characterized in vitro. 15,25 Defects in DC maturation may, in part, contribute to the unpolarized T cell phenotype observed during L. amazonensis infection, 6 and lead to a non-healing immune response. As early as 7 dpi CD11c ϩ DLN cells from L. amazonensis-infected C3HeB/FeJ mice have significantly reduced CD40 surface expression and a decreased number of IL-12p40-producing cells, as compared with L. major-infected mice.…”
Section: Discussionmentioning
confidence: 99%
“…L. amazonensis modulates DC maturation through activation of ERK1/2 [11], altering a critical step for promotion of a T helper 1 immune response and clearance of L. amazonensis infection [2123]. It was previously unknown if L. amazonensis -mediated ERK1/2 phosphorylation was an active process by the parasite or produced by cell entry via phagocytosis.…”
Section: Discussionmentioning
confidence: 99%
“…L. amazonensis utilizes the hosts scaffolding complex and because use of this complex provides spatial specificity, L. amazonensis brings ERK1/2 next to the vacuole it inhabits (Figure 6B). Use of a PV/endosomal-specific p14/MP1 scaffold complex promotes sustained ERK1/2 phosphorylation [53], alteration of the phagocyte oxidative burst [56] and leads to chronic infection [54, 53, 76, 77]. L. amazonensis has been shown to inhabit the perinuclear region within its PV [78-80].…”
Section: Introductionmentioning
confidence: 99%