1998
DOI: 10.1038/sj.onc.1202187
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Antigen receptor signaling: integration of protein tyrosine kinase functions

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Cited by 106 publications
(89 citation statements)
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References 110 publications
(140 reference statements)
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“…1 -generated signals activate Syk, Btk, and Src family protein tyrosine kinases during B lymphocyte activation (1)(2)(3)(4)(5). Kinase activation in turn propagates multiple downstream signaling events including tyrosine phosphorylation of important transmembrane receptors, phosphoinositide generation, increases in calcium mobilization into the cytoplasm, and the activation of mitogen-activated protein kinases (MAPKs).…”
Section: B Cell Antigen Receptor (Bcr)mentioning
confidence: 99%
“…1 -generated signals activate Syk, Btk, and Src family protein tyrosine kinases during B lymphocyte activation (1)(2)(3)(4)(5). Kinase activation in turn propagates multiple downstream signaling events including tyrosine phosphorylation of important transmembrane receptors, phosphoinositide generation, increases in calcium mobilization into the cytoplasm, and the activation of mitogen-activated protein kinases (MAPKs).…”
Section: B Cell Antigen Receptor (Bcr)mentioning
confidence: 99%
“…This family includes only two members: Syk, which is present in most hematopoietic cells and ZAP-70, which is exclusively expressed in T and NK cells. As documented by several studies, the expression of Syk and ZAP-70 is essential for lymphocyte development and signal transduction via IRs (13)(14)(15)(16). The association of phosphorylated ITAMs with SH2 domains of Syk family PTKs leads to the activation of Syk and ZAP-70 mainly by autophosphorylation (17), thus allowing the propagation of IR signaling.…”
mentioning
confidence: 99%
“…The Src-family PTKs such as Lyn are located immediately downstream of BCR, and their activation is followed by the activation of two other PTKs, Syk and Btk (1)(2)(3)(4). It has been demonstrated that the activation of Btk depends, at least partially, on the activity of Lyn.…”
mentioning
confidence: 99%