Antigen Protease Activity with a Detergent Induces Severe Skin Inflammation with Itch and Robust T Helper 17/T Helper 22 Differentiation in Mice

Yoshimura, Tomoko; Kamijo, Seiji; Ichikawa, Saori; Kimitsu, Toru; Masutani, Yurie; Shimizu, Saya; Takada, Keiko; Ogawa, Takasuke; Tominaga, Mitsutoshi; Takamori, Kenji; Ogawa, Hideoki; Okumura, Ko; Ikeda, Shigaku; Takai, Toshiro

doi:10.1016/j.jid.2023.03.1685

Cited by 2 publications

(1 citation statement)

References 17 publications

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“…Nonatopic healthcare workers had a significant TEWL increase after hand sanitizer use compared with nonatopic nonhealthcare workers ( P < 0.05), suggesting that healthcare workers have a compromised skin barrier from frequent hand hygiene. In mice, exposure to the cytotoxic ingredients in detergents caused increase in pro-inflammatory cytokines with increased TEWL [73 ▪ ] and skin inflammation with itch and upregulation of cytokines involved in allergic responses [74 ▪ ,75 ▪ ].…”

Section: Detergentsmentioning

confidence: 99%

Physical influences on the skin barrier and pathogenesis of allergy

Hui-Beckman,

Leung

2023

Current Opinion in Pediatrics

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Purpose of review As the incidence of allergic conditions has increased in recent decades, the effects of climate change have been implicated. There is also increased knowledge on the effects of other physical influences, such as scratching and Staphylococcus aureus. The skin barrier is the first line of defense to the external environment, so understanding the ways that these factors influence skin barrier dysfunction is important. Recent findings Although the impact on environmental exposures has been well studied in asthma and other allergic disorders, there is now more literature on the effects of temperature, air pollution, and detergents on the skin barrier. Factors that cause skin barrier dysfunction include extreme temperatures, air pollution (including greenhouse gases and particulate matter), wildfire smoke, pollen, scratching, S. aureus, and detergents. Summary Understanding the ways that external insults affect the skin barrier is important to further understand the mechanisms in order to inform the medical community on treatment and prevention measures for atopic conditions.

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Section: Detergentsmentioning

confidence: 99%