Antigen-Presenting Cells in Psoriasis

Antal, Dóra; Alimohammadi, Shahrzad; Bai, Péter; Szöllősi, Attila Gábor; Szántó, Magdolna

doi:10.3390/life12020234

Cited by 9 publications

(3 citation statements)

References 90 publications

(111 reference statements)

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“…Another positive correlation between chemerin levels, inflammatory cytokines, and C-reactive protein was reported in Ps [ 45 , 46 ]. Chemerin acts as a chemotactic factor for human blood plasmacytoid dendritic cells (pDCs), promoting their migration and recruitment in psoriatic skin [ 47 ]. Skin exhibiting early and active lesions shows high expression of chemerin in the dermis, while skin exhibiting chronic lesions has low chemerin expression, associated with few pDCs in the dermis.…”

Section: Psoriatic Patients and Obesitymentioning

confidence: 99%

Insights into Nutritional Strategies in Psoriasis

et al. 2023

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Psoriasis, an autoimmune chronic inflammatory skin condition, has a high incidence in the general population, reaching 2–4%. Its pathogenesis involves an interplay of genetic factors, immune disturbances, and environmental factors. Within the environmental factors that aid the appearance of this autoimmune skin disease, the Western lifestyle and overall diet play important roles in the steady growth in psoriasis prevalence. Furthermore, psoriasis is associated with comorbidities such as psoriatic arthritis, cardiovascular disease, metabolic syndrome, and obesity. Accumulating evidence suggests that obesity is an important risk factor for psoriasis. Moreover, obesity aggravates established psoriasis, and a reduction in the body mass index can improve the clinical outcomes of psoriasis and increase the efficacy of standard psoriasis therapies. The possible connection between this autoimmune disease and obesity relies on the fact that white adipose tissue is an essential endocrine organ that secretes an array of immune mediators and inflammatory and metabolic factors with pro-inflammatory action. Thus, immune-mediated mechanisms in both psoriasis and obesity conditions are common factors. This paper describes the factors that link obesity with skin autoimmune disease and highlights the importance of the stimulatory or regulatory effects of nutrients and food in psoriasis and the possible improvement of psoriasis through nutritional strategies.

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Section: Psoriatic Patients and Obesitymentioning

confidence: 99%

Insights into Nutritional Strategies in Psoriasis

et al. 2023

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“…There are abundant results reporting on the role of LCs in psoriasis [2,21]. In experimental mouse models [22], it was demonstrated that the IL-23/Th17 axis is involved in the psoriasis-like inflammation [23].…”

Section: Role Of Langerhans Cells In Psoriasismentioning

confidence: 99%

Langerhans Cells—Revising Their Role in Skin Pathologies

Neagu

Constantin

Jugulete

et al. 2022

JPM

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Langerhans cells (LCs) constitute a cellular immune network across the epidermis. Because they are located at the skin barrier, they are considered immune sentinels of the skin. These antigen-presenting cells are capable of migrating to skin draining lymph nodes to prime adaptive immune cells, namely T- and B-lymphocytes, which will ultimately lead to a broad range of immune responses. Moreover, LCs have been shown to possess important roles in the anti-cancer immune responses. Indeed, the literature nicely highlights the role of LCs in melanoma. In line with this, LCs have been found in melanoma tissues where they contribute to the local immune response. Moreover, the immunogenic properties of LCs render them attractive targets for designing vaccines to treat melanoma and autoimmune diseases. Overall, future studies will help to enlarge the portfolio of immune properties of LCs, and aid the prognosis and development of novel therapeutic approaches to treating skin pathologies, including cancers.

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“…Extended author information available on the last page of the article disease relevant, but recently, it was shown that keratinocyteproduced IL23A in itself is sufficient to initiate psoriasis-like skin inflammation [5]. Moreover, the IL17A signaling of keratinocytes has an important contribution to the development of psoriasis in mice [6], suggesting that besides T cells, keratinocytes are also critical players in psoriasis pathogenesis [7]. Keratinocytes are either in a differentiated state or in pathological conditions; they become activated [8].…”

Section: Introductionmentioning

confidence: 99%

PARP2 promotes inflammation in psoriasis by modulating estradiol biosynthesis in keratinocytes

et al. 2023

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Poly(ADP-ribose) polymerase 2 (PARP2) alongside PARP1 are responsible for the bulk of cellular PARP activity, and they were first described as DNA repair factors. However, research in past decades implicated PARPs in biological functions as diverse as the regulation of cellular energetics, lipid homeostasis, cell death, and inflammation. PARP activation was described in Th2-mediated inflammatory processes, but studies focused on the role of PARP1, while we have little information on PARP2 in inflammatory regulation. In this study, we assessed the role of PARP2 in a Th17-mediated inflammatory skin condition, psoriasis. We found that PARP2 mRNA expression is increased in human psoriatic lesions. Therefore, we studied the functional consequence of decreased PARP2 expression in murine and cellular human models of psoriasis. We observed that the deletion of PARP2 attenuated the imiquimod-induced psoriasis-like dermatitis in mice. Silencing of PARP2 in human keratinocytes prevented their hyperproliferation, maintained their terminal differentiation, and reduced their production of inflammatory mediators after treatment with psoriasis-mimicking cytokines IL17A and TNFα. Underlying these observations, we found that aromatase was induced in the epidermis of PARP2 knock-out mice and in PARP2-deficient human keratinocytes, and the resulting higher estradiol production suppressed NF-κB activation, and hence, inflammation in keratinocytes. Steroidogenic alterations have previously been described in psoriasis, and we extend these observations by showing that aromatase expression is reduced in psoriatic lesions. Collectively, our data identify PARP2 as a modulator of estrogen biosynthesis by epidermal keratinocytes that may be relevant in Th17 type inflammation. Key messages PARP2 mRNA expression is increased in lesional skin of psoriasis patients. PARP2 deletion in mice attenuated IMQ-induced psoriasis-like dermatitis. NF-κB activation is suppressed in PARP2-deficient human keratinocytes. Higher estradiol in PARP2-deficient keratinocytes conveys anti-inflammatory effect.

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Antigen-Presenting Cells in Psoriasis

Cited by 9 publications

References 90 publications

Insights into Nutritional Strategies in Psoriasis

Insights into Nutritional Strategies in Psoriasis

Langerhans Cells—Revising Their Role in Skin Pathologies

PARP2 promotes inflammation in psoriasis by modulating estradiol biosynthesis in keratinocytes

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