Antigen in chitosan coated liposomes enhances immune responses through parenteral immunization

Behera, T.; Swain, P.; Sahoo, Sanjeeb K.

doi:10.1016/j.intimp.2011.02.002

Cited by 18 publications

(7 citation statements)

References 60 publications

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“…This was explained by strong adsorption between the polymer and the liposomal bilayer [35]. However, some aggregations were observed after coating [44,46,55,57].…”

Section: Morphologymentioning

confidence: 99%

“…This discrepancy may be due to drug physicochemical properties (solubility, partition coefficient, ionization), its location in vesicles and orientation inside the liposomal membrane, as well as the medium pH. For example, many studies demonstrated that chitosan coating decreased the EE of drugs, mostly having positive charges at pH range between 4 and 7.4 compared to uncoated liposomes as presented in Tables 2-5 [5,34,35,37,38,40,42,48,[56][57][58][59]. It was explained as a consequence of positively charged chitosan and positively charged drug competing for the negatively charged phospholipids [34,37,40,48].…”

Section: Encapsulation Efficiencymentioning

confidence: 99%

See 1 more Smart Citation

Chitosan-Coating Effect on the Characteristics of Liposomes: A Focus on Bioactive Compounds and Essential Oils: A Review

et al. 2021

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In recent years, liposomes have gained increasing attention for their potential applications as drug delivery systems in the pharmaceutic, cosmetic and food industries. However, they have a tendency to aggregate and are sensitive to degradation caused by several factors, which may limit their effectiveness. A promising approach to improve liposomal stability is to modify liposomal surfaces by forming polymeric layers. Among natural polymers, chitosan has received great interest due to its biocompatibility and biodegradability. This review discussed the characteristics of this combined system, called chitosomes, in comparison to those of conventional liposomes. The coating of liposomes with chitosan or its derivatives improved liposome stability, provided sustained drug release and increased drug penetration across mucus layers. The mechanisms behind these results are highlighted in this paper. Alternative assembly of polyelectrolytes using alginate, sodium hyaluronate, or pectin with chitosan could further improve the liposomal characteristics. Chitosomal encapsulation could also ensure targeted delivery and boost the antimicrobial efficacy of essential oils (EOs). Moreover, chitosomes could be an efficient tool to overcome the major drawbacks related to the chemical properties of EOs (low water solubility, sensitivity to oxygen, light, heat, and humidity) and their poor bioavailability. Overall, chitosomes could be considered as a promising strategy to enlarge the use of liposomes.

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“…This was explained by strong adsorption between the polymer and the liposomal bilayer [35]. However, some aggregations were observed after coating [44,46,55,57].…”

Section: Morphologymentioning

confidence: 99%

Section: Encapsulation Efficiencymentioning

confidence: 99%

Chitosan-Coating Effect on the Characteristics of Liposomes: A Focus on Bioactive Compounds and Essential Oils: A Review

et al. 2021

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“…Chitosan modified particles produced potent Th1 and Th2 maturation 124. Similar results were seen with liposomes coated with chitosan, demonstrating the versatility of its use 125. Even when administered alongside but not physically associated with antigen, chitosan nanoparticles produced a humoral response higher than antigen alone but not comparable to the positive control.…”

Section: Particles For Delivery Of Antigens and Adjuvants: Artificmentioning

confidence: 52%

Micro and Nanoparticle‐Based Delivery Systems for Vaccine Immunotherapy: An Immunological and Materials Perspective

Leleux

Roy

2012

Adv Healthcare Materials

173

148

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The development and widespread application of vaccines has been one of the most significant achievements of modern medicine. Vaccines have not only been instrumental in controlling and even eliminating life-threatening diseases like polio, measles, diphtheria, etc., but have also been immensely powerful in enhancing the worldwide outlook of public health over the past century. Despite these successes, there are still many complex disorders (e.g., cancer, HIV, and other emerging infectious diseases) for which effective preventative or therapeutic vaccines have been difficult to develop. This failure can be attributed primarily to our inability to precisely control and modulate the highly complex immune memory response, specifically the cellular response. Dominated by B and T cell maturation and function, the cellular response is primarily initiated by potent immunostimulators and antigens. Efficient and targeted delivery of these immunomodulatory and immunostimulatory molecules to appropriate cells is key to successful development of next generation vaccine formulations. Over the past decade, particulate carriers have emerged as an attractive means for enhancing the delivery efficacy and potency of vaccines and associated immunomodulatory molecules. Specifically, polymer-based micro and nanoparticles are being extensively studied for a wide variety of applications. In this review, we discuss the immunological fundamentals for developing effective vaccines and how materials and material properties can be exploited to improve these therapies. Particular emphasis is given to polymer-based particles and how the route of administration of particulate systems affects the phenotype and robustness of an immune response. Comparison of various strategies and recent advancements in the field are discussed along with insights into current limitations and future directions.

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“…Nevertheless, the primary drawback hampering the application of liposomes is the general lack of stability under physiological conditions, which often leads to a burst release of the encapsulated drugs, with undesirable side reactions. [23,24] Therefore, there is a pressing need to improve the stability of liposomes.…”

Section: Introductionmentioning

confidence: 99%

Design and Synthesis of Lipidic Organoalkoxysilanes for the Self‐Assembly of Liposomal Nanohybrid Cerasomes with Controlled Drug Release Properties

Liang

Jing

et al. 2013

Chemistry A European J

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This paper reports the facile design and synthesis of a series of lipidic organoalkoxysilanes with different numbers of triethoxysilane headgroups and hydrophobic alkyl chains linked by glycerol and pentaerythritol for the construction of cerasomes with regulated surface siloxane density and controlled release behavior. It was found that the number of triethoxysilane headgroups affected the properties of the cerasomes for encapsulation efficiency, drug loading capacity, and release behavior. For both water-soluble doxorubicin (DOX) and water-insoluble paclitaxel (PTX), the release rate from the cerasomes decreased as the number of triethoxysilane headgroups increased. The slower release rate from the cerasomes was attributed to the higher density of the siloxane network on the surface of the cerasomes, which blocks the drug release channels. In contrast to the release results with DOX, the introduction of one more hydrophobic alkyl chain into the cerasome-forming lipid resulted in a slower release rate of PTX from the cerasomes due to the formation of a more compact cerasome bilayer. An MTT viability assay showed that all of these drug-loaded cerasomes inhibited proliferation of the HepG2 cancer cell line. The fine tuning of the chemical structure of the cerasome-forming lipids would foster a new strategy to precisely regulate the release rate of drugs from cerasomes.

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Antigen in chitosan coated liposomes enhances immune responses through parenteral immunization

Cited by 18 publications

References 60 publications

Chitosan-Coating Effect on the Characteristics of Liposomes: A Focus on Bioactive Compounds and Essential Oils: A Review

Chitosan-Coating Effect on the Characteristics of Liposomes: A Focus on Bioactive Compounds and Essential Oils: A Review

Micro and Nanoparticle‐Based Delivery Systems for Vaccine Immunotherapy: An Immunological and Materials Perspective

Design and Synthesis of Lipidic Organoalkoxysilanes for the Self‐Assembly of Liposomal Nanohybrid Cerasomes with Controlled Drug Release Properties

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