Antigen exposure in the late light period induces severe symptoms of food allergy in an OVA-allergic mouse model

Tanabe, Kazuhisa; Kitagawa, Eri; Wada, Misaki; Haraguchi, Atsushi; Orihara, Kanami; Tahara, Yu; Nakao, Akihiro; Shibata, Shigenobu

doi:10.1038/srep14424

Cited by 24 publications

(36 citation statements)

References 43 publications

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“…The evaluation of diarrhea symptom was carried out as previous research (Hyung et al, 2017;Tanabe et al, 2015). The severity of diarrhea was assessed to a value of 0-3 using feces between 30 and 60 min after the challenge of PN.…”

Section: Clinical Hypersensitivity Signs Of Micementioning

confidence: 99%

Antiallergic activity of Lactobacillus plantarum against peanut allergy in a Balb/c mouse model

Yang

Liu

Guo

et al. 2019

Food and Agricultural Immunology

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Long (2019) Antiallergic activity of Lactobacillusplantarum against peanut allergy in a Balb/c mouse model, Food and Agricultural Immunology, 30:1, 762-773, ABSTRACT Antiallergic activities of Lactobacillus plantarum (L. plantarum) prepared from kimchi as orally administered probiotics were examined in type I peanut allergy mice models. Oral administration with L. plantarum restored the deteriorated profile of enteric flora in mice sensitized with peanut allergen and attenuated allergic symptoms, including diarrhea scores, clinical scores, serum specific immunoglobulin E (IgE) and histamine production. The mRNA expression of interleukin-10 and interferon-γ was suppressed and enhanced, respectively by L. plantarum administration. Thus, L. plantarum probably promoted anti-allergic activities via modulating enteric flora, intestinal cytokines mRNA expression in type I allergic mice, resulting in alleviation of allergic symptoms, including serum specific IgE and clinical hypersensitivity scores. Abbreviations: LAB: lactic acid bacteria; ELISA: enzyme-linked immunosorbent assay; IFN: interferon; IL: interleukin; PBS: phosphate-buffered saline; PCR: polymerase chain reaction; PN: Ara h 2 in peanut; mRNA: messenger ribonucleic acid; IgE: immunoglobulin E.; L. plantarum: Lactobacillus plantarum ARTICLE HISTORY

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Section: Clinical Hypersensitivity Signs Of Micementioning

confidence: 99%

Antiallergic activity of Lactobacillus plantarum against peanut allergy in a Balb/c mouse model

Yang

Liu

Guo

et al. 2019

Food and Agricultural Immunology

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show abstract

“…Finally, it should be mentioned that circadian variations in the expression of tight junction proteins may be responsible for diurnal fluctuations in intestinal permeability. This has been reported in both the small (Tanabe et al, 2015) and large intestines (Oh‐oka et al, 2014) in mice. In mouse jejunum, occludin and claudin‐3 mRNA levels are significantly higher at the night period, suggesting that intestinal permeability may be higher in the light period (Tanabe et al, 2015).…”

Section: Chronopharmacokinetics: Non‐clinical Datamentioning

confidence: 56%

Timing in drug absorption and disposition: The past, present, and future of chronopharmacokinetics

Bicker

Alves

Falcão

2020

British J Pharmacology

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The importance of drug dosing time in pharmacokinetics, pharmacodynamics, and toxicity is receiving increasing attention from the scientific community. In spite of mounting evidence that circadian oscillations affect drug absorption, distribution, metabolism, and excretion (ADME), there remain many unanswered questions in this field and, occasionally, conflicting experimental results. Such data arise not only from translational difficulties caused by interspecies differences but also from variability in study design and a lack of understanding of how the circadian clock affects physiological factors that strongly influence ADME, namely, the expression and activity of drug transporters. Hence, the main goal of this review is to provide an updated analysis of the role of the circadian rhythm in drug absorption, distribution across bloodtissue barriers, metabolism in hepatic and extra-hepatic tissues, and hepatobiliary and renal excretion. It is expected that the research suggestions proposed here will contribute to a tissue-targeted and time-targeted pharmacotherapy.

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“…49 In the context of food allergy, mice orally administered with OVA antigen during the light (ie, rest) period presented a higher secretion of type 2 cytokines, such as IL-13 and IL-5, in mesenteric lymph nodes than the mice of a night period-treated group. 50 As mentioned before, glucocorticoids seem to be involved in the control of cytokine secretion. In the human studies described earlier, the Th1/Th2 ratio is lower in the early night/sleep phase and shifts toward Th1 cells by the end of the night, when the plasma cortisol is high.…”

Section: Circadian Control Of T Cell Subsetsmentioning

confidence: 88%

Circadian control of antigen-specific T cell responses

Nobis¹,

Labrecque²,

Cermakian³

2016

CPT

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The immune system is composed of two arms, the innate and the adaptive immunity. While the innate response constitutes the first line of defense and is not specific for a particular pathogen, the adaptive response is highly specific and allows for long-term memory of the pathogen encounter. T lymphocytes (or T cells) are central players in the adaptive immune response. Various aspects of T cell functions vary according to the time of day. Circadian clocks located in most tissues and cell types generate 24-hour rhythms of various physiological processes. These clocks are based on a set of clock genes, and this timing mechanism controls rhythmically the expression of numerous other genes. Clock genes are expressed in cells of the immune system, including T cells. In this review, we provide an overview of the circadian control of the adaptive immune response, with emphasis on T cells, including their development, trafficking, response to antigen, and effector functions. Bmal1 REV-ERB Clock-controlled genes Rhythmic enzymes, receptors, cytokines, transcription factors, etc ROR CLOCK PER CRY Cry1,2 Per1, 2, 3 Rev-Erbα, β Rorα, β, γ BMAL1 Figure 1The basic circadian clock mechanism in mammals. Notes: Most cells in the organism have a circadian clock, whose mechanism relies on a set of clock genes. The CLOCK/BMAL1 transcription factor complex positively regulates Per and Cry genes. PeR and CRY proteins accumulate and then form complexes, enter the nucleus, and inhibit their own expression by repressing CLOCK/BMAL1 activity. in parallel, CLOCK/BMAL1 activates the Rev-Erb and Ror genes. ROR factors positively regulate Bmal1 gene expression, whereas Rev-eRB factors repress it. Clock transcription factors, such as CLOCK/BMAL1 and Rev-eRBα, also regulate rhythmically the transcription of many other genes termed clock-controlled genes, which encode various types of proteins and constitute the output of the circadian clock.ChronoPhysiology and Therapy downloaded from https: //www.dovepress.com/ by 44.224.250.200 on 05-Aug-2020 For personal use only. Dovepress 74 Nobis et alChronoPhysiology and Therapy downloaded from https: //www.dovepress.com/ by 44.224.250.200 on 05-Aug-2020 For personal use only.

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Antigen exposure in the late light period induces severe symptoms of food allergy in an OVA-allergic mouse model

Cited by 24 publications

References 43 publications

Antiallergic activity of Lactobacillus plantarum against peanut allergy in a Balb/c mouse model

Antiallergic activity of Lactobacillus plantarum against peanut allergy in a Balb/c mouse model

Timing in drug absorption and disposition: The past, present, and future of chronopharmacokinetics

Circadian control of antigen-specific T cell responses

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