Antiganglioside Antibodies in Sub Types of Guillain-Barre Syndrome in an Indian Population

Meena, A K; Akalkotkar, Archana; Reddy, G. C.; Ramakrishna, D; Rao, Pragna

doi:10.3923/jms.2010.138.142

Cited by 4 publications

(6 citation statements)

References 17 publications

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“…Of note, these results are not consistent with a recent review of an unspecified number of cases by Gupta et al [70], which suggested that acute motor axonal neuropathy (AMAN) and AMSAN are the most common GBS subtypes associated with COVID-19. The inconsistency in the proportions of GBS subtypes could be attributed to possible genetic variation, with evidence indicating a higher prevalence of AIDP in the western world, while AMAN and AMSAN are more prevalent in Asian and Southern and Central American populations [71]. Interestingly however, in this study, AMAN accounted for only 2.17% of the cases, which is even lower than the rare MFS subtype that accounted for 6.52% of the cases in this study.…”

Section: Discussioncontrasting

confidence: 78%

COVID-19-Associated Guillain-Barre Syndrome: Atypical Para-infectious Profile, Symptom Overlap, and Increased Risk of Severe Neurological Complications

Kajumba

Kolls

Koltai

et al. 2020

SN Compr. Clin. Med.

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The concurrence of COVID-19 with Guillain-Barre syndrome (GBS) can increase the likelihood of neuromuscular respiratory failure, autonomic dysfunction, and other life-threatening symptoms. Currently, very little is known about the underlying mechanisms, clinical course, and prognostic implications of comorbid COVID-19 in patients with GBS. We reviewed COVID-19associated GBS case reports published since the outbreak of the pandemic, with a database search up to August 2020, including a manual search of the reference lists for additional relevant cases. Fifty-one (51) case reports of COVID-19 patients (aged 23-84 years) diagnosed with GBS in 11 different countries were included in this review. The results revealed atypical manifestations of GBS, including para-infectious profiles and onset of GBS without antecedent COVID-19 symptoms. Although all tested patients had signs of neuroinflammation, none had SARS-CoV-2 in the cerebrospinal fluid (CSF), and only four (4) patients had antiganglioside antibodies. The majority had a 1-to 10-day time interval between the onset of COVID-19 and GBS symptoms, and many had a poor outcome, with 20 out of the 51 (39.2%) requiring mechanical ventilation, and two deaths within 12 to 24 h. The atypical manifestations of COVID-19-associated GBS, especially the para-infectious profile and short time interval between the onset of the COVID-19 and GBS symptoms, increase the likelihood of symptom overlap, which can complicate the treatment and result in worsened disease progression and/or higher mortality rates. Inclusion of a neurological assessment during diagnosis of COVID-19 might facilitate timely identification and effective management of the GBS symptoms and improve treatment outcome.

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Section: Discussioncontrasting

confidence: 78%

COVID-19-Associated Guillain-Barre Syndrome: Atypical Para-infectious Profile, Symptom Overlap, and Increased Risk of Severe Neurological Complications

Kajumba

Kolls

Koltai

et al. 2020

SN Compr. Clin. Med.

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“…Depending on the screening parameters and GBS subtypes under investigation, the prevalence of the wide spectrum of anti-glycolipid Abs found in GBS sera ranges from 38% to 100% (Chiba et al, 1992;Alaedini et al, 2002;Caudie et al, 2002;Mata et al, 2006;Yu et al, 2006;Meena et al, 2010). The Abs are predominantly of immunoglobulin (Ig) G subclass (Caudie et al, 2002;Mata et al, 2006;Kaida et al, 2007;Meena et al, 2010), with IgG1 and IgG3 dominating (Willison and Yuki, 2002).…”

Section: Introductionmentioning

confidence: 99%

Anti‐GM2 ganglioside antibodies are a biomarker for acute canine polyradiculoneuritis

Rupp

Galban-Horcajo

Bianchi

et al. 2013

J Peripheral Nervous Sys

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Acute canine polyradiculoneuritis (ACP) is considered to be the canine equivalent of the human peripheral nerve disorder Guillain-Barré syndrome (GBS); an aetiological relationship, however, remains to be demonstrated. In GBS, anti-glycolipid antibodies (Abs) are considered as important disease mediators. To address the possibility of common Ab biomarkers, the sera of 25 ACP dogs, 19 non-neurological, and 15 epileptic control dogs were screened for IgG Abs to 10 glycolipids and their 1 : 1 heteromeric complexes using combinatorial glycoarrays. Anti-GM2 ganglioside Abs were detected in 14/25 ACP dogs, and anti-GA1 Abs in one further dog. All controls except for one were negative for anti-glycolipid Abs. In this cohort of cases and controls, the glycoarray screen reached a diagnostic sensitivity of 60% and a specificity of 97%; a lower sensitivity (32%) was reported using a conventional glycolipid ELISA. To address the possible pathogenic role for anti-GM2 Abs in ACP, we identified GM2 in canine sciatic nerve by both mass spectrometry and thin layer chromatography overlay. In immunohistological studies, GM2 was localized predominantly to the abaxonal Schwann cell membrane. The presence of anti-GM2 Abs in ACP suggests that it may share a similar pathophysiology with GBS, for which it could thus be considered a naturally occurring animal model.

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“…These results support the results of various studies done in the past on similar subject in 1999 by Khalili et al and in 2010 by Meena et al,. 10,11 All other investigations related to the diagnosis of GBS are either invasive or expensive or operator dependent. Neurodiagnostic studies involving nerve conduction studies and lumbar puncture for CSF analysis both have their own merits and demerits and patients have to wait and spend a lot for these investigations.…”

Section: Discussionmentioning

confidence: 99%

“…Disorders and Stroke from 1990. 11,12 Acute progressive symmetric weakness of the extremities with areflexia or hyporeflexia, Albumino-cytological dissociation in cerebrospinal fluid (raised protein and total cell count of ≤10/mm 3 ) and demyelinating/axonal neuropathy on electrophysiological studies were the parameters considered in the diagnosis of GBS among the study participants.…”

Section: Gbs Diagnosis Was Made According To Diagnostic Criteria From...mentioning

confidence: 99%

“…An enzymelinked immunosorbent assay (ELISA) was used to detect the various types of antiganglioside antibodies, including immunoglobulin G (IgG) and immunoglobulin M (IgM) antibodies against the gang-liosides GM1, GM2, GM3, GD1a, GD1b, GD3, GT1a, GT1b, and GQ1b, as described previously. 11 Although they are not true gangliosides, testing was also performed for galacto-cerebroside and asialo-GM1. The presence and types of anti-ganglioside antibodies were analyzed by researchers who were blinded to the patients' presenting neurological signs and electrophysiological classifications.…”

Section: Gbs Diagnosis Was Made According To Diagnostic Criteria From...mentioning

confidence: 99%

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Assessment of Anti-Ganglioside Antibodies in Patients Diagnosed With Guillain Barre Syndrome

Hassan

Gilani²,

Alamgir³

et al. 2022

PAFMJ

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Objective: To assess the frequency of patients positive for the presence of anti-ganglioside antibodies and factors related to it among the patients diagnosed with Guillian Barre Syndrome (GBS) at our hospital. Study Design: Prospective longitudinal study. Place and Duration of Study: Pak Emirates Military Hospital Rawalpindi, from Jan to Jun 2019. Methodology: Patients were included in the study once detailed assessment and investigations have been carried out by the consultant neurologist and he has declared the patient suffering from Guillian Barre Syndrome. Anti-ganglioside antibodies were performed on all the patients diagnosed with Guillian Barre Syndrome from the immunology department of the laboratory of our hospital. Factors like age, gender, preceding gastrointestinal infection; sensory involvement and need for mechanical ventilation were related with the presence of Guillian Barre Syndrome in our target population. Results: A total of 30 patients were enrolled in the study. Out of these 22 (73.3%) were positive for the presence of antiganglioside antibodies while 08 (26.4%) did not show the presence of detectable levels of these antibodies in their serum. On fisher exact test preexisting gastrointestinal infection and sensory involvement were statistically significantly related to the presence of anti-ganglioside antibodies among the patients suffering from Guillian Barre Syndrome. Conclusion: Relationship of presence of anti-ganglioside antibodies was strong with the Guillian Barre Syndrome among the patients enrolled in our study. It was even stronger in among the patients who presented with the sensory involvement or those who had a gastrointestinal infection prior to the onset of symptoms of...........

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Antiganglioside Antibodies in Sub Types of Guillain-Barre Syndrome in an Indian Population

Cited by 4 publications

References 17 publications

COVID-19-Associated Guillain-Barre Syndrome: Atypical Para-infectious Profile, Symptom Overlap, and Increased Risk of Severe Neurological Complications

COVID-19-Associated Guillain-Barre Syndrome: Atypical Para-infectious Profile, Symptom Overlap, and Increased Risk of Severe Neurological Complications

Anti‐GM2 ganglioside antibodies are a biomarker for acute canine polyradiculoneuritis

Assessment of Anti-Ganglioside Antibodies in Patients Diagnosed With Guillain Barre Syndrome

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