Antifúngicos disponibles para el tratamiento de las micosis ungueales

Carrillo-Muñoz, Alfonso Javier; Tur-Tur, Cristina; Hernández-Molina, Juan Manuel; Santos, Patricia; Cárdenes, Delia; Giusiano, Gustavo

doi:10.1016/j.riam.2010.01.007

Cited by 24 publications

(16 citation statements)

References 78 publications

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“…The last three, however, require elevated concentrations to achieve a fungistatic effect, which is consistent with the mechanism of action of azole antifungals. 43 …”

Section: Discussionmentioning

confidence: 99%

Clinical, epidemiological, and therapeutic profile of dermatophytosis

Pires

Cruz

Lobato

et al. 2014

An. Bras. Dermatol.

101

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BACKGROUNDThe cutaneous mycoses, mainly caused by dermatophyte fungi, are among the most common fungal infections worldwide. It is estimated that 10% to 15% of the population will be infected by a dermatophyte at some point in their lives, thus making this a group of diseases with great public health importance.OBJECTIVETo analyze the clinical, epidemiological, and therapeutic profile of dermatophytosis in patients enrolled at the Dermatology service of Universidade do Estado do Pará, Brazil, from July 2010 to September 2012.METHODA total of 145 medical records of patients diagnosed with dermatophytosis were surveyed. Data were collected and subsequently recorded according to a protocol developed by the researchers. This protocol consisted of information regarding epidemiological and clinical aspects of the disease and the therapy employed.RESULTSThe main clinical form of dermatophyte infection was onychomycosis, followed by tinea corporis, tinea pedis, and tinea capitis. Furthermore, the female population and the age group of 51 to 60 years were the most affected. Regarding therapy, there was a preference for treatments that combine topical and systemic drugs, and the most widely used drugs were fluconazole (systemic) and ciclopirox olamine (topical).CONCLUSIONThis study showed the importance of recurrent analysis of the epidemiological profile of dermatophytosis to enable correct therapeutic and preventive management of these conditions, which have significant clinical consequences, with chronic, difficult-totreat lesions that can decrease patient quality of life and cause disfigurement.

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“…The last three, however, require elevated concentrations to achieve a fungistatic effect, which is consistent with the mechanism of action of azole antifungals. 43 …”

Section: Discussionmentioning

confidence: 99%

Clinical, epidemiological, and therapeutic profile of dermatophytosis

Pires

Cruz

Lobato

et al. 2014

An. Bras. Dermatol.

101

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“…Onychomycosis caused by A. terreus complex presents similar clinical patterns to those caused by dermatophytes, with less predictable treatments and a high rate of therapeutic failure. Better knowledge of the aetiological agents and their in vitro sensitivity is important for accomplishing more accurate and effective treatments …”

Section: Discussionmentioning

confidence: 99%

Aspergillus terreus complex: an emergent opportunistic agent of Onychomycosis

Fernández

Rojas

Cattana

et al. 2013

Mycoses

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The incidence of onychomycosis due to non-dermatophyte moulds (NDM) is increasing. Aspergillus terreus is relatively undocumented as an agent of this fungal infection. The aim of this work is to show the prevalence of onychomycosis caused by A. terreus and to describe its clinical features. Nail samples were collected for microscopic examination and culturing in selective media. All cases of onychomycosis due to NDM were confirmed by a second sample. Aspergillus terreus isolates were identified through their morphological characteristics and using molecular methods. A total of 2485 samples were obtained. Positive cultures were obtained in 1639 samples. From 124 NDM confirmed cultures, 23 were identified as A. terreus (18.5%). Superficial white onychomycosis was the most frequent clinical pattern. A high percentage was found in fingernails. The prevalence of A. terreus in this study considerably exceeded the percentages reported by other authors. Onychomycosis due to A. terreus presents similar clinical patterns to those caused by dermatophytes, but is difficult to eradicate and is associated with less predictable treatment outcomes. Better knowledge of the aetiology of A. terreus may be important for accomplishing more accurate and effective treatment.

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“…This mycosis represents an important medical problem because it involves the patient’s life quality and it has high cost on treatment 4 . The onychomycosis requires prolonged treatment and it has poor response to therapy 5 …”

Section: Introductionmentioning

confidence: 99%