Antifungal terpenoids produced by cypress after infection by Diplodia pinea f. sp. cupressi

Madar, Z.; Gottlieb, Hugo E.; Cojocaru, Miriam; Riov, J.; Solel, Z.; Sztejnberg, A.

doi:10.1016/0031-9422(94)00575-e

Cited by 27 publications

(14 citation statements)

References 6 publications

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“…The de novo compounds we found could, thus, likely be antifungal phytoalexins because i) sabinene hydrate, camphor, and α-terpineol appeared exclusively in the infected treatments, ii) they are oxygenated monoterpenes, iii) their antifungal activity has been reported in literature (especially α-terpineol), and iv) the report by Madar et al (1995a). The possibility that these de novo compounds (especially α-terpineol and camphor) are a product or a biotransformation of the infecting fungal pathogen, however, cannot be discarded (Kusumoto et al 2014;Leufvén et al 1988;Siddhardha et al 2011;Tan and Day 1998).…”

Section: Discussionmentioning

confidence: 59%

“…Most of the de novo compounds were detected in relatively low concentrations (0.09-0.36 mg g −1 dw) except for de novo 3, a diterpene that had a mean concentration of 5.4 mg g −1 but was rarely detected. We were not able to detect cupressotropolone A and B, two sesquiterpene phytoalexins of fungal-infected cypresses discovered by Madar et al (1995a) using thin layer chromatography (TLC).…”

Section: Discussionmentioning

confidence: 75%

“…The only de novo terpenes known to be produced by Italian cypress in response to a fungal pathogen are the oxygenated sesquiterpenes cupressutropolone A and B, produced under infection by Diplodia pinea, another canker-causing fungus (Madar et al 1995a). These two sesquiterpenes are considered C. sempervirens phytoalexins, because they cause strong or total inhibition of mycelial growth and spore germination for S. cardinale and other cypress pathogens (Madar et al 1995a).…”

Section: Discussionmentioning

confidence: 99%

“…These two sesquiterpenes are considered C. sempervirens phytoalexins, because they cause strong or total inhibition of mycelial growth and spore germination for S. cardinale and other cypress pathogens (Madar et al 1995a).…”

Section: Discussionmentioning

confidence: 99%

“…cupressi, another canker-causing fungal pathogen (Madar et al 1995a, b). These phytoalexins showed substantial activity against several fungal pathogens of cypress, including S. cardinale (Madar et al 1995a). Moderate antifungal activity of the essential oil of C. sempervirens leaves was observed against fungal pathogens of other hosts (Mazari et al 2010).…”

Section: Introductionmentioning

confidence: 99%

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Strong Induction of Minor Terpenes in Italian Cypress, Cupressus sempervirens, in Response to Infection by the Fungus Seiridium cardinale

Achotegui-Castells

Danti²,

Llusià

et al. 2015

J Chem Ecol

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Seiridium cardinale, the main fungal pathogen responsible for cypress bark canker, is the largest threat to cypresses worldwide. The terpene response of canker-resistant clones of Italian cypress, Cupressus sempervirens, to two differently aggressive isolates of S. cardinale was studied. Phloem terpene concentrations, foliar terpene concentrations, as well as foliar terpene emission rates were analyzed 1, 10, 30, and 90 days after artificial inoculation with fungal isolates. The phloem surrounding the inoculation point exhibited de novo production of four oxygenated monoterpenes and two unidentified terpenes. The concentrations of several constitutive mono-and diterpenes increased strongly (especially α-thujene, sabinene, terpinolene, terpinen-4-ol, oxygenated monoterpenes, manool, and two unidentified diterpenes) as the infection progressed. The proportion of minor terpenes in the infected cypresses increased markedly from the first day after inoculation (from 10 % in the control to 30-50 % in the infected treatments). Foliar concentrations showed no clear trend, but emission rates peaked at day 10 in infected trees, with higher δ-3-carene (15-fold) and total monoterpene (10-fold) emissions than the control. No substantial differences were found among cypresses infected by the two fungal isolates. These results suggest that cypresses activate several direct and indirect chemical defense mechanisms after infection by S. cardinale.

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Section: Discussionmentioning

confidence: 59%

Section: Discussionmentioning

confidence: 75%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Strong Induction of Minor Terpenes in Italian Cypress, Cupressus sempervirens, in Response to Infection by the Fungus Seiridium cardinale

Achotegui-Castells

Danti²,

Llusià

et al. 2015

J Chem Ecol

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Plant‐Microbe Interactions and Secondary Metabolites with Antiviral, Antibacterial and Antifungal Properties

Reichling

2018

Annual Plant Reviews Online

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Plant–Microbe Interactions and Secondary Metabolites with Antibacterial, Antifungal and Antiviral Properties

Reichling

2018

Annual Plant Reviews Online

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Plants have developed effective defence strategies to protect themselves from phytopathogenic microbes and herbivores in their environment. Disease resistance in plants depends on the activation of coordinated, multicomponent defence mechanisms. One mechanism for disease resistance in plants is their ability to accumulate low‐molecular‐weight compounds (secondary metabolites) with high antimicrobial activities, such as alkaloids, coumarins, isoflavonoids, polyacetylenes, quinones, tannins and terpenes.Based on this knowledge, there is every reason to believe that the plant kingdom is an important source of new antimicrobial agents with special biological targets. Thus, in the last two decades, hundreds of different new secondary metabolites were screened for their potential antibacterial, antifungal and antiviral activities. For instance, several secondary metabolites with antiviral properties have exhibited competitive in vitro and in vivo activities with those found for synthetic antiviral drugs. It has been shown that phyto‐antiviral agents interfere with many viral targets, ranging from adsorption of the virus to the host cell via the inhibition of virus‐specific enzymes (e.g. reverse transcriptase, protease) to release virus from the cells.It is generally accepted that bioactive plant‐derived secondary metabolites are useful leads to synthesize new and more active antimicrobial agents as well as substances with new pharmacological effects by repeated structural modification. It is expected that structurally modified natural products will exhibit increased potency, selectivity, duration of action, bioavailability and reduced toxicity.

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Antifungal terpenoids produced by cypress after infection by Diplodia pinea f. sp. cupressi

Cited by 27 publications

References 6 publications

Strong Induction of Minor Terpenes in Italian Cypress, Cupressus sempervirens, in Response to Infection by the Fungus Seiridium cardinale

Strong Induction of Minor Terpenes in Italian Cypress, Cupressus sempervirens, in Response to Infection by the Fungus Seiridium cardinale

Plant‐Microbe Interactions and Secondary Metabolites with Antiviral, Antibacterial and Antifungal Properties

Plant–Microbe Interactions and Secondary Metabolites with Antibacterial, Antifungal and Antiviral Properties

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