Antifungal Susceptibility Patterns of Opportunistic Fungi in the Genera Verruconis and Ochroconis

Seyedmousavi, Seyedmojtaba; Samerpitak, Kittipan; Rijs, Antonius J. M. M.; Melchers, Willem J. G.; Mouton, Johan W.; Verweij, Paul E.; Hoog, G.S. de

doi:10.1128/aac.00002-14

Cited by 28 publications

(20 citation statements)

References 50 publications

(50 reference statements)

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“…This underscores the need for validated, rapid diagnostics to improve clinical outcomes [38]. Selection of early and appropriate antifungal therapy is essential, as non-Aspergillus moulds have variable antifungal susceptibilities [14,15,35]. Management of these infections was complex and prolonged.…”

Section: Discussionmentioning

confidence: 97%

“…Two V. gallapova infections were observed, both in neutropenic haematology patients with adverse outcomes despite combination therapy with posaconazole or voriconazole and amphotericin B, all of which have, in general, good in vitro activity against V. gallopava [35]. Nonetheless, overall, dematiaceous moulds were associated with lower mortality than other non-Aspergillus IFDs, which is similar to recent findings of phaeomycotic infections in SOT recipients (7% mortality), although most of these had skin rather than disseminated infection [10].…”

Section: Discussionmentioning

confidence: 98%

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Invasive infections due to filamentous fungi other than Aspergillus: epidemiology and determinants of mortality

Slavin

Hal

Sorrell

et al. 2015

Clinical Microbiology and Infection

147

143

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The epidemiology of invasive fungal disease (IFD) due to filamentous fungi other than Aspergillus may be changing. We analysed clinical, microbiological and outcome data in Australian patients to determine the predisposing factors and identify determinants of mortality. Proven and probable non-Aspergillus mould infections (defined according to modified European Organization for Research and Treatment of Cancer/Mycoses Study Group criteria) from 2004 to 2012 were evaluated in a multicentre study. Variables associated with infection and mortality were determined. Of 162 episodes of non-Aspergillus IFD, 145 (89.5%) were proven infections and 17 (10.5%) were probable infections. The pathogens included 29 fungal species/species complexes; mucormycetes (45.7%) and Scedosporium species (33.3%) were most common. The commonest comorbidities were haematological malignancies (HMs) (46.3%) diabetes mellitus (23.5%), and chronic pulmonary disease (16%); antecedent trauma was present in 21% of cases. Twenty-five (15.4%) patients had no immunocompromised status or comorbidity, and were more likely to have acquired infection following major trauma (p <0.01); 61 (37.7%) of cases affected patients without HMs or transplantation. Antifungal therapy was administered to 93.2% of patients (median 68 days, interquartile range 19-275), and adjunctive surgery was performed in 58.6%. The all-cause 90-day mortality was 44.4%; HMs and intensive-care admission were the strongest predictors of death (both p <0.001). Survival varied by fungal group, with the risk of death being significantly lower in patients with dematiaceous mould infections than in patients with other non-Aspergillus mould infections. Non-Aspergillus IFD affected diverse patient groups, including non-immunocompromised hosts and those outside traditional risk groups; therefore, definitions of IFD in these patients are required. Given the high mortality, increased recognition of infections and accurate identification of the causative agent are required.

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Section: Discussionmentioning

confidence: 97%

Section: Discussionmentioning

confidence: 98%

Invasive infections due to filamentous fungi other than Aspergillus: epidemiology and determinants of mortality

Slavin

Hal

Sorrell

et al. 2015

Clinical Microbiology and Infection

147

143

View full text Add to dashboard Cite

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“…Previously, Dactylaria gallopava and then O. gallopava , modern molecular methods have now placed this fungus into the genus Verruconis because of its thermotolerance, separating it from the thermolabile genus Ochroconi s [7], [10].…”

Section: Discussionmentioning

confidence: 99%

Verruconis gallopava cardiac and endovascular infection with dissemination after renal transplantation: Case report and lessons learned

Jennings

Kable

Halliday

et al. 2017

Medical Mycology Case Reports

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Verruconis gallopava is an uncommon cause of phaeohyphomycosis. We describe an unusual case of disseminated V. gallopava infection in a renal transplant recipient involving the endocardium but without endocarditis, associated with fungaemia and infection in the skin, oral cavity, brain and lung. The isolate was first detected from blood cultures which is rare. Surgical resection of cardiac fungal mass was not possible. The patient died despite resolution of fungaemia and combination antifungal therapy.

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“…These reports emphasise the aggressive nature of infection when caused by V. gallopava . MIC breakpoints are not yet available for this phaeohyphomycete, but ranges have been reported as follows: amphotericin B 0.125–4.0 mg/L, andidulofungin 0.016–0.25 mg/L, caspofungin 0.25–1.0 mg/L, fluconazole 4 –>64 mg/L, flucytosine 0.125–>16 mg/L, itraconazole <0.016 –>16 mg/L, posaconazole <0.016–0.25 mg/L and voriconazole 0.125–8 mg/L 10. Our isolates’ MICs fell into these ranges and are reported in table 1.…”

Section: Discussionmentioning

confidence: 99%

Double invasive fungal infection due to dematiaceous moulds in a renal transplant patient

Helou¹,

Palavecino

Núñez

2018

BMJ Case Reports

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and are two dematiaceous moulds that occasionally cause disease in immunocompromised hosts. We present the case of a 58-year-old man with history of deceased donor renal transplantation 14 months prior, who presented with fevers and cough. He was found to have right upper lobe pneumonia and a non-healing eschar of his right knee. Dematiaceous fungi grew from bronchoalveolar lavage (BAL) and was sent to reference lab for identification. Meanwhile, the eschar on his right knee was biopsied and grew spp. Pathology was consistent with invasive mould infection and he was treated as having disseminated infection with voriconazole and amphotericin B lipid complex. Later on, the dematiaceous mould from a BAL specimen was identified as The patient was discharged on voriconazole awaiting minimal inhibitory concentrations for but was readmitted 2 days later with high fevers and died from acute respiratory failure.

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Antifungal Susceptibility Patterns of Opportunistic Fungi in the Genera Verruconis and Ochroconis

Cited by 28 publications

References 50 publications

Invasive infections due to filamentous fungi other than Aspergillus: epidemiology and determinants of mortality

Invasive infections due to filamentous fungi other than Aspergillus: epidemiology and determinants of mortality

Verruconis gallopava cardiac and endovascular infection with dissemination after renal transplantation: Case report and lessons learned

Double invasive fungal infection due to dematiaceous moulds in a renal transplant patient

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