Antifungal susceptibilities, biofilms, phospholipase and proteinase activities in the Candida rugosa complex and Candida pararugosa isolated from tertiary teaching hospitals

Peremalo, T.; Madhavan, Priya; Hamzah, Sharina; Than, Leslie Thian Lung; Wong, Eng Hwa; Desa, Mohd Nasir Mohd; Chong, Pei Pei; Ng, Kee Peng

doi:10.1099/jmm.0.000940

Cited by 8 publications

(5 citation statements)

References 39 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…ese circumstances made us think of a single day of fluconazole treatment as a chance event in relation to clinical resolution. Like other Candida species, C. pararugosa produces biofilms, especially in prosthetic materials [16]. erefore, we think that the removal of the central catheter, along with possible biofilm, was instrumental in resolution of the infection, maintained with continuance of antifungal therapy.…”

Section: Discussionmentioning

confidence: 94%

Catheter-Related Sepsis by Candida pararugosa in an Adult Patient under Chemotherapy Regimen

Piatti

Feltrin

Fellini

et al. 2021

Case Reports in Infectious Diseases

View full text Add to dashboard Cite

Candida pararugosa is present in animals and humans in different organs and biological liquids, usually as a saprophyte. We report the case of a 61-year-old woman diagnosed with de novo stage IV metastatic lobular breast cancer, carrying a central venous catheter (port-a-cath) and bilateral stents for perirenal infiltration by malignancy. During chemotherapy regimen, a febrile episode occurred, along with a high level of serum glucan. The port-a-cath was removed after blood collection for culture, which gave isolation of Candida pararugosa strains. Given high glucan level and the patient’s frailty, empirical treatment with fluconazole was started with load-dose, 800 mg orally, at day 1 and, afterwards, with 400 mg daily for two weeks. The phenotype of susceptibility to antibiotics of the strain demonstrated lower minimal inhibitory concentration to fluconazole than that reported in the literature. The patient remained asymptomatic, and inflammation parameters showed normalization. Unfortunately, three weeks later, meningeal localization of cancer caused rapid deterioration and death.

show abstract

Section: Discussionmentioning

confidence: 94%

Catheter-Related Sepsis by Candida pararugosa in an Adult Patient under Chemotherapy Regimen

Piatti

Feltrin

Fellini

et al. 2021

Case Reports in Infectious Diseases

View full text Add to dashboard Cite

show abstract

“…4 Several clusters of candidemia caused by C. rugosa have been reported in specific limited area, showing high mortality. [4][5][6] It has been reported that 11.4% to 16.4% of patients with candidemia develop endophthalmitis. 3 However, it has been pointed out that the incidence of Candida endophthalmitis to date may be overestimated due to its ambiguous definition.…”

Section: Discussionmentioning

confidence: 99%

“… 4 Several clusters of candidemia caused by C. rugosa have been reported in specific limited area, showing high mortality. 4 – 6 …”

Section: Discussionmentioning

confidence: 99%

“…Furthermore, it has been indicated that C. rugosa shows strong resistance to general antifungal agents, including fluconazole and echinocandins, and no safe or effective treatment method has been established to date. 1 , 6 Therefore, it is necessary to monitor the worsening of systemic symptoms and recurrence of ocular lesions because of reactivation.…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Atypical Endogenous Fungal Endophthalmitis Caused by Candida Rugosa

Koide

Yamamoto

Kobayashi

et al. 2023

RETINAL Cases &Amp; Brief Reports

View full text Add to dashboard Cite

Purpose: The purpose of this study was to report a case of atypical endogenous fungal endophthalmitis caused by Candida rugosa, a rare species of nonalbicans Candida. Methods: This report describes a case of a 45-year-old woman who presented with a reduced visual acuity in the right eye in addition to vitreous opacity during breast cancer treatment, which was suspected as fungal endophthalmitis from medical examination and history. Various tests were performed for diagnosis. Results: Blood test results were normal, including the blood beta-D-glucan level, and blood cultures were negative. Diagnosis could not be made using systemic computed tomography and magnetic resonance imaging results. Therefore, a lesion sample was collected by using vitrectomy. C. rugosa was identified through DNA (extracted from the lesion sample) analysis using Basic Local Alignment Search Tool. The visual acuity of the right eye improved after vitrectomy. Conclusion: We encountered a rare case of atypical endogenous fungal endophthalmitis caused by C. rugosa. Clinicians sometimes encounter invasive candidiasis caused by rare nonalbicans Candida species. DNA analysis using Basic Local Alignment Search Tool is effective for diagnosing such cases.

show abstract

“…A observação de que C. rugosa foi a espécie mais encontrada no presente estudo pode estar associada por ter se tornado um patógeno emergente em humanos capazes de produzir fatores de virulência como as enzimas proteinase, esterase, hemolisina e biofilme (Singh et al, 2016;Peremalo et al, 2019) e em animais, está principalmente associada à mastite. C. rugosa já foi reconhecido como agente etiológico de mastite em 14 vacas leiteiras durante um surto de contaminação ambiental sendo isolado também da ração, água e curral, o que demonstrou sua capacidade de sobreviver em diferentes ambientes e, portanto, de espalhar-se mais facilmente no ambiente (Scaccabarozzi et al, 2011).…”

Section: Discussionunclassified

Isolamento e perfil de resistência de Candida spp. de animais domésticos e selvagens

Cândido

Menezes

Nakazato

et al. 2021

RSD

View full text Add to dashboard Cite

Candida spp. são leveduras presentes na microbiota de humanos e animais, porém devido a desordens podem se tornar patogênicas causando candidíase. Este estudo objetivou avaliar a diversidade de espécies de Candida em animais domésticos e silvestres e o perfil de susceptibilidade antifúngica. Um total de 79 isolados foram obtidos de animais domésticos (n=49) e animais silvestres (n=30) coletados de 13 diferentes sítios de lesão. Os isolados foram previamente caracterizados morfológica e tintorialmente e a classificação definitiva ocorreu pelo sequenciamento de DNA da região ITS. O perfil de susceptibilidade foi obtido pela técnica de microdiluição em caldo com os antifúngicos: caspofungina, fluconazol, voriconazol, anfotericina B, nistatina e itraconazol. Doze diferentes espécies de Candida foram identificadas, onde C. rugosa foi a espécie mais isolada (26%; 21/79), seguida por C. parapsilosis (20%; 16/79) e C. albicans (15%, 12/79). O perfil de susceptibilidade foi avaliado em 30 isolados (10 isolados de C. glabrata, 10 isolados de C. tropicalis e 10 isolados de C. parapsilosis), resultando em 100% dos isolados testados resistentes ao itraconazol, porém nenhum deles foi resistente ao voriconazol. Os isolados de C. tropicalis foram resistentes a múltiplos antifúngicos. Esses dados alertam para o problema mundial de resistência a antimicrobianos, agravado pelo aparecimento de cepas resistentes a múltiplos fármacos. Este é o primeiro estudo que verificou a ocorrência e os perfis de resistência de Candida spp. em animais no Estado de Mato Grosso, Centro-oeste, Brasil, demonstrando a necessidade de novos trabalhos para continuidade da compreensão da relação entre estas leveduras e seus hospedeiros.

show abstract

Antifungal susceptibilities, biofilms, phospholipase and proteinase activities in the Candida rugosa complex and Candida pararugosa isolated from tertiary teaching hospitals

Cited by 8 publications

References 39 publications

Catheter-Related Sepsis by Candida pararugosa in an Adult Patient under Chemotherapy Regimen

Catheter-Related Sepsis by Candida pararugosa in an Adult Patient under Chemotherapy Regimen

Atypical Endogenous Fungal Endophthalmitis Caused by Candida Rugosa

Isolamento e perfil de resistência de Candida spp. de animais domésticos e selvagens

Contact Info

Product

Resources

About