Antifungal Styryloquinolines as Candida albicans Efflux Pump Inhibitors: Styryloquinolines are ABC Transporter Inhibitors

Cieślik, Wioleta; Szczepaniak, Joanna; Krasowska, Anna; Musioł, Robert

doi:10.3390/molecules25020345

Cited by 17 publications

(7 citation statements)

References 52 publications

(61 reference statements)

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“…Recently, the activity of four different Styryloquinoline compounds as ABC transport pump inhibitors and the role of the hydroxyl group attached to the quinolone moiety was investigated, the study reveals that the addition of unprotected hydroxyl group at carbon 4 and 8 in the quinolone moiety dramatically increased the antifungal activity against a wild and mutant strain of Candida species. Additionally, the same compound demonstrates a strong synergistic action when combined with fluconazole [46].…”

Section: Discussionmentioning

confidence: 96%

Prevalence of vulvovaginal candidiasis among pregnant women in Africa: A systematic review and meta-analysis

Mohamed

Mohamed²,

Mallhi³

et al. 2022

J Infect Dev Ctries

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Introduction: Vulvovaginal candidiasis (VVC) is a yeast infection of the vulva, which is caused by Candida species and affects women worldwide. Pregnant women are more vulnerable to VVC due to certain risks. Moreover, their offspring are also exposed to the risk of preterm birth. In this context, ascertaining the burden of VVC is of paramount importance and this meta-analysis was conducted to estimate the occurrence of VVC among pregnant women in Africa. Methodology: Database search was carried out through PubMed, Scopus, Science-Direct, and Google Scholar from the date of inception until December 2020. All the studies on the prevalence of VVC among African pregnant women were included in the analysis. The pooled prevalence was estimated based on the Random-effect model DerSimonian-Laird approach with Freeman- Tukey double arcsine transformed proportion. Heterogeneity was assessed using I2 test and subsequently explored using subgroup and meta-regression analysis. Results: A total of Sixteen records having a sample size 4,185 were included in this study. The overall prevalence of VVC was pooled at 29.2% (CI 95%: 23.4 – 33.0). Subgroup analysis revealed a higher prevalence in Eastern Africa, followed by Western Africa and North Africa (35%, 28%, and 15% respectively). Moderator analysis indicated that the studies that used advanced methods of detection had a higher prevalence (p = 0.048). In addition, the large sample size was associated with higher prevalence (p ≤ 0.001). No other moderators were found to be statistically significant. Conclusions: The overall prevalence of VVC among African pregnant women is comparable to other studies worldwide. However, appropriate identification techniques and larger sample size could likely be associated with an increased prevalence. Our findings necessitate the need for further investigations to determine the geographical distribution of VVC across African regions.

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Section: Discussionmentioning

confidence: 96%

Prevalence of vulvovaginal candidiasis among pregnant women in Africa: A systematic review and meta-analysis

Mohamed

Mohamed²,

Mallhi³

et al. 2022

J Infect Dev Ctries

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“…Other styrylquinolines have been tested against mutant strains of C. albicans . Compound 17i showed great activity against the strain from which the efflux pump gene was deleted, suggesting it is a substrate for the efflux pump, unlike Amphotericin B, which showed constant MIC values for all strains …”

Section: Structural Changes At the 8hq Core Based On The Microorganis...mentioning

confidence: 99%

“…Compound 17i showed great activity against the strain from which the efflux pump gene was deleted, suggesting it is a substrate for the efflux pump, unlike Amphotericin B, which showed constant MIC values for all strains. 108 The antimicrobial SAR of 8HQ derivatives with structural changes at position 2 are summarized in the Figures 21−23. Several modifications were evaluated regarding the antibacterial activity, highlighting aryl groups, alkyl chains, and saturated heterocycles.…”

Section: ■ Introductionmentioning

confidence: 99%

Novel Antimicrobial 8-Hydroxyquinoline-Based Agents: Current Development, Structure–Activity Relationships, and Perspectives

et al. 2021

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The search for new antimicrobials is imperative due to the emergent resistance of new microorganism strains. In this context, revisiting known classes like 8-hydroxyquinolines could be an interesting strategy to discover new agents. The 8-hydroxyquinoline derivatives nitroxoline and clioquinol are used to treat microbial infections; however, these drugs are underused, being available in few countries or limited to topical use. After years of few advances, in the last two decades, the potent activity of clioquinol and nitroxoline against several targets and the privileged structure of 8-hydroxyquinoline nucleus have prompted an increased interest in the design of novel antimicrobial, anticancer, and anti-Alzheimer agents based on this class. Herein, we discuss the current development and antimicrobial structure–activity relationships of this class in the perspective of using the 8-hydroxyquinoline nucleus for the search for novel antimicrobial agents. Furthermore, the most investigated molecular targets concerning 8-hydroxyquinoline derivatives are explored in the final section.

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“…While compound 9 offered lower antifungal activity, which could be attributed to the oxygen atom of the ether 20,21 . Whereas the hydroxyl moiety of the compound 3 could be the cause of its antifungal effect 22 .…”

Section: ________________________________________________________________________________________________________________mentioning

confidence: 99%

Synthesis, antioxidant and antimicrobial activities for new 4,4'-methylenedianiline amide compounds

Mahmood

2021

Egypt. J. Chem.

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Free radicals are particles that have an unpaired electron. If they produced in high level in our bodies, they can cause damage to lipids, proteins, and DNA. Antioxidants are any compounds that can incorporate free radicals in a safe way, cease the reaction, and switch them to a risk-free molecule by donating a proton. The infectious diseases are among the chief causes of death worldwide, and antimicrobial resistance has been regularly reported globally. Thus, these complications necessitate the investigation for new therapies with potential antioxidant and antimicrobial activities. This study aims to design, synthesize and evaluate the antioxidant and antimicrobial activities of new N,N'-(dialkoyl/diaroyl)-4,4'-methylenedianiline compounds. These compounds were synthesized by the reaction of carboxylic acids with 4,4'-methylenedianiline in presence of N,N'dicyclohexylcarbodiimide (DCC) as coupling agent. The structures of the synthesized compounds were characterized on the bases of the physical and spectral data. The antioxidant activity of these compounds was evaluated by testing their free radical scavenging activity of DPPH and H2O2 and their antimicrobial activity was evaluated via measuring the inhibition zones in the disk diffusion method. The synthesized compounds show varied antioxidant and antimicrobial activities. The hydroxyl and the amide moieties in the synthesized compound possess similar potent antioxidant activities. The fluoro-aromatic compound showed potent antibacterial and antifungal activities. While the chloro aliphatic and aromatic compounds showed only antibacterial activity. Whereas aromatic fluorine and the ether group exposed a potent antifungal activity if they incorporated in any organic compound.

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Antifungal Styryloquinolines as Candida albicans Efflux Pump Inhibitors: Styryloquinolines are ABC Transporter Inhibitors

Cited by 17 publications

References 52 publications

Prevalence of vulvovaginal candidiasis among pregnant women in Africa: A systematic review and meta-analysis

Prevalence of vulvovaginal candidiasis among pregnant women in Africa: A systematic review and meta-analysis

Novel Antimicrobial 8-Hydroxyquinoline-Based Agents: Current Development, Structure–Activity Relationships, and Perspectives

Synthesis, antioxidant and antimicrobial activities for new 4,4'-methylenedianiline amide compounds

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