Antifungal screening of 61 folkloric medicinal plant extracts against dermatophytic fungi Trichophyton rubrum

Abstract

A series 305 extracts from 61 traditional medicinal plants (belonging to 33 different families) used in treating skin diseases in Hyderabad Karnataka region were subjected to antidermatophytic screening against Trichophyton rubrum (MTCC 1344). Pet ether, chloroform, ethyl acetate, methanol and aqueous extracts of each plant were tested for their antifungal activity using agar well diffusion method at sample concentration of 5 & 2.5 mg/ml. The results indicated that out of 61 plants, 18 exhibited very effective antidermatophytic activity in methanolic extracts, effective activity observed in 13 plants in different extracts, whereas 26 plants showed moderate activity, 04 plants showed weak activity. The minimum inhibitory concentrations of 18 very effective plants were determined. On the basis of the results obtained, the crude extracts of Allium sativam Linn. Zingiber officinale exhibited significant antidermatophytic activity (T. rubrum) and properties that support folkloric use in the treatment of skin diseases as broad-spectrum antimycotic agents. This probably explains the use of these plants by the indigenous people against dermatological infections.

In vitro analysis of antimicrobial and phytochemical properties of crude extracts of selected plants against the tomato wilt disease

“…The present findings also concur with those of other studies on antifungal activities of extracts from members of the Euphorbiaceae family, where root extracts recorded larger zones of inhibition zones than bark extracts (Rajeh et al, 2010;Karimi et al, 2011), but such variations attribute to the variations in phytochemical composition can be expected for different plant species (Vallejo et al, 2003;Randrianalijaona et al, 2005). Previous investigations involving extracts of E. tirucalli also indicate its antimicrobial activity against various fungal strains like Candida albicans (Bhalodia and Shukla, 2011;Singh and Vidyasagar, 2015). The bark extracts of E. tirucalli are also documented to be effective against F. oxysporum and other fungal pathogens (Rathi et al, 2012;de Araújo et al, 2014).…”

Antidermatophytic activity of synthetic peptides: Action mechanisms and clinical application as adjuvants to enhance the activity and decrease the toxicity of Griseofulvin

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Chemical Characterization and the Antimicrobial Potential of Species of the Genus Senna Mill. (Fabaceae)

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