Antifungal Resistance of Clinical Candida albicans Isolates in Iran: A Systematic Review and Meta-Analysis

Kermani, Firoozeh; Armaki, Mojtaba Taghizadeh; Hosseini, Seyed Abdollah; Amirrajab, Nasrin; Javidnia, Javad; Zaghrami, Mahmoud Fami; Shokohi, Tahereh

doi:10.18502/ijph.v52i2.11874

ijph

2023

DOI: 10.18502/ijph.v52i2.11874

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Antifungal Resistance of Clinical Candida albicans Isolates in Iran: A Systematic Review and Meta-Analysis

Firoozeh Kermani¹,

Mojtaba Taghizadeh Armaki²,

Seyed Abdollah Hosseini³

et al.

Abstract: Background: The present systematic review aimed to investigate the drug susceptibility patterns of Iranian clinical Candida albicans isolates to antifungal drugs (azoles, polyenes, and echinocandins). Methods: Six electronic databases including “PubMed,” “Scopus,” “Web of Science,” “IranDoc”, “SID”, and “Magiran” were searched from May 2000 to June 2021. The susceptibility of 6322 C. albicans strains from 19967 patients against 14 antifungal drugs was evaluated according to CLSI method. Results: Th… Show more

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Factors’ analysis associated with adverse outcome of the treatment of patients with invasive candidiasis

Popovic,

Begovic-Kupresanin

2023

Srp Arh Celok Lek

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Introduction/Objective. Invasive candidiasis (IC) is the most common invasive fungal infection in humans. It manifests as candidemia, and can affect internal organs and lead to sepsis and septic shock. A good knowledge of the factors that lead to the morbidity and mortality of these patients is necessary. We aimed to investigate the factors associated with the unfavorable outcome of patients with IC treated in our institution. Methods. The research was conducted at the Military Medical Academy in Belgrade, Serbia. The retrospective cohort study included 145 patients of both sexes, aged over 18 years, with a proven diagnosis of invasive candidiasis. Demographics, comorbidities, use of therapeutic procedures, antibiotics, antifungal treatment and outcome were compared between deceased and surviving patients with invasive candidiasis. The results were analyzed using Student's t-test, Mann-Whitney U test, multivariate statistical analysis. Results. The results showed that the predictors of death were DM (adjusted OR 6.886; CI 2.608-18.178; p = 0.000) and chemotherapy (adjusted OR 6.826; 95% CI: 2.037-22.866; p = 0.002), which increase the risk for death seven times compared to the basal risk and mechanical ventilation, which increases the risk of death about three times (adjusted OR: 3.056; 95% CI: 1.132-8.253; p = 0.012). Conclusion. Optimal treatment is necessary in terms of early detection and identification of the causative agent of IC. In susceptible patients, such as immunocompromised patients, appropriate treatment should be initiated as soon as possible.

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Factors’ analysis associated with adverse outcome of the treatment of patients with invasive candidiasis

Popovic,

Begovic-Kupresanin

2023

Srp Arh Celok Lek

View full text Add to dashboard Cite

show abstract

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Antifungal Resistance of Clinical Candida albicans Isolates in Iran: A Systematic Review and Meta-Analysis

Cited by 1 publication

References 52 publications

Factors’ analysis associated with adverse outcome of the treatment of patients with invasive candidiasis

Factors’ analysis associated with adverse outcome of the treatment of patients with invasive candidiasis

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