Antimicrobial Drug Resistance 2009
DOI: 10.1007/978-1-60327-595-8_19
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Antifungal Resistance: Aspergillus

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Cited by 4 publications
(7 citation statements)
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“…While echinocandin resistance in Aspergillus is at this point a laboratory phenomenon, triazole resistance is an emerging clinical threat in many regions of the world (17)(18)(19)(20)(21). To our knowledge, this is the first in vivo, dose-ranging pharmacodynamic study examining the effects of combination triazole and echinocandin therapy against Cyp51 wild-type and mutant isolates.…”
Section: ͼ40mentioning
confidence: 97%
See 1 more Smart Citation
“…While echinocandin resistance in Aspergillus is at this point a laboratory phenomenon, triazole resistance is an emerging clinical threat in many regions of the world (17)(18)(19)(20)(21). To our knowledge, this is the first in vivo, dose-ranging pharmacodynamic study examining the effects of combination triazole and echinocandin therapy against Cyp51 wild-type and mutant isolates.…”
Section: ͼ40mentioning
confidence: 97%
“…However, the recent emergence of A. fumigatus isolates exhibiting reduced susceptibility to triazoles is a threat to this class (17)(18)(19)(20)(21). We theorized that consideration of the pharmacokinetics (PK) and pharmacodynamics (PD) of the triazole-echinocandin interaction would advance our understanding of the utility of this combination strategy.…”
mentioning
confidence: 99%
“…Amino acid variations at M220 leads to pan-azole resistance (6), whereas alterations at E427 in association with another amino acid change(s) confer resistance to Itz and Vcz but not to Pcz (3). G448S amino acid alterations confer high-level resistance to Vcz but only low-level resistance to Itz and Pcz (7,8). In most cases, a single amino acid change is sufficient for conferring resistance in the strain carrying the variant protein.…”
Section: T Riazole Resistance Among Environmental and Clinical Isolatmentioning
confidence: 99%
“…Tissues for mould culture should be thoroughly macerated and incubated on media for moulds (e.g., brain heart infusion, Sabhi or similar) and inhibitory media if bacterial contamination is expected (Inhibitory Mould Agar) [28]. Identification of Aspergillus, should be at the species level if possible as this may determine choice and response to antifungal therapy [29]. Macroscopic characteristics, microscopic appearance of hyphae and conidial head usually provide species identification in experienced hands.…”
Section: Microbiologymentioning
confidence: 99%