Antifungal Potential of Plant Species From Brazilian Caatinga Against Dermatophytes

Abstract

Trichophyton rubrum and Trichophyton mentagrophytes complex, or Trichophyton spp. are the main etiologic agents of dermatophytosis, whose treatment is limited by the high cost of antifungal treatments, their various side effects, and the emergence of resistance amongst these species. This study evaluated the in vitro antidermatophytic activity of 23 crude extracts from nine plant species of semiarid vegetation (caatinga) found in Brazil. The extracts were tested at concentrations ranging from 1.95 to 1,000.0 mg/mL by broth microdilution assay against the reference strains T. rubrum ATCC 28189 and T. mentagrophytesATCC 11481, and 33 clinical isolates of dermatophytes. All plants showed a fungicidal effect against both fungal species, with MIC/MFC values of the active extracts ranging from 15.6 to 250.0 µg/mL. Selected extracts of Eugenia uniflora (AcE), Libidibia ferrea (AE), and Persea americana (AcE) also exhibited a fungicidal effect against all clinical isolates of T. rubrum and T. mentagrophytes complex. This is the first report of the antifungal activity of Schinus terebinthifolius, Piptadenia colubrina, Parapiptadenia rigida, Mimosa ophthalmocentra, and Persea americana against both dermatophyte species.

Effect of the Ethyl Acetate Fraction of Eugenia uniflora on Proteins Global Expression during Morphogenesis in Candida albicans

“…(Victoria et al, 2012 ). The antifungal activity of several E. uniflora leaf fraction extracts were also observed against Trichophyton rubrum and T. mentagrophytes (Biasi-Garbin et al, 2016 ) and Candida species (Ferreira et al, 2013 ). Therefore, we used the ethyl acetate (EAF) fraction of this natural product by obtaining a fraction enriched in polyphenols.…”

Caracterização anatômica e histoquímica das folhas de Eugenia uniflora L.

“…Encontram-se, na literatura, estudos que reportam efeitos antidiarreico (Almeida et al, 1995), antidiabético (Arai et al, 1999), antimicrobiano Biasi-Garbin et al, 2016), antioxidante (Sobral-Souza et al, 2014;Schumacher et al, 2015), hepatoprotetor (Victoria et al, 2013), antinociceptivo e hipotérmico (Amorim et al, 2009), anti-Trypanosoma cruzi (Santos et al, 2012;Azeredo et al, 2014) e antiLeishmania (Rodrigues et al, 2013) para as folhas de E. uniflora.…”

Influence of Eugenia uniflora Extract on Adhesion to Human Buccal Epithelial Cells, Biofilm Formation, and Cell Surface Hydrophobicity of Candida spp. from the Oral Cavity of Kidney Transplant Recipients

“…The contents of gallic acid and myricitrin were calculated based with the calibration curves of the respective standards, and the results found were 0.16 g% ± 0.0017 (1.42) and 0.43 g% ± 0.0006 (0.01), respectively. Much research has shown the anti- Candida activity potential of plant-derived compounds such as flavonoids and essential oils [ 28 , 29 , 30 ].…”