Antifungal nortriterpene and triterpene glycosides from the sea cucumber Apostichopus japonicus Selenka

Wang, Zenglei; Zhang, Hongwei; Yuan, Weiping; Gong, Wei; Tang, Hua; Liu, Bao‐Shu; Krohn, Karsten; Li, Ling; Yi, Yang‐Hua; Zhang, Wen

doi:10.1016/j.foodchem.2011.10.080

Cited by 54 publications

(45 citation statements)

References 17 publications

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“…This suggests that the Δ 25 terminal double bond may increase the activity. This point of view correlates well with the data on the structure-activity relationship of triterpene glycosides reported by Wang et al [3] who suggested that the 18(20) lactone moiety and Δ 25 double bond may increase the activity.…”

Section: Antifungal Activitysupporting

confidence: 91%

“…There is a dried sea cucumber market on the Internet () and over-the-counter in encapsulated form as dietary health supplements and nutraceuticals for humans and companion animals in the United States and Canada [2]. In the Qin dynasty in China, sea cucumbers were considered as a good remedy equal to ginseng for “yin deficiency of kidney, ischemia, dysentery and ulcers” [3]. Many Asians consume sea cucumbers to cure disorders including asthma, hypertension, cancer and arthritis, as well as intestinal and urinary dysfunctions [4].…”

Section: Introductionmentioning

confidence: 99%

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Acetylated Triterpene Glycosides and Their Biological Activity from Holothuroidea Reported in the Past Six Decades

Bahrami

Franco

2016

Marine Drugs

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Sea cucumbers have been valued for many centuries as a tonic and functional food, dietary delicacies and important ingredients of traditional medicine in many Asian countries. An assortment of bioactive compounds has been described in sea cucumbers. The most important and abundant secondary metabolites from sea cucumbers are triterpene glycosides (saponins). Due to the wide range of their potential biological activities, these natural compounds have gained attention and this has led to their emergence as high value compounds with extended application in nutraceutical, cosmeceutical, medicinal and pharmaceutical products. They are characterized by bearing a wide spectrum of structures, such as sulfated, non-sulfated and acetylated glycosides. Over 700 triterpene glycosides have been reported from the Holothuroidea in which more than 145 are decorated with an acetoxy group having 38 different aglycones. The majority of sea cucumber triterpene glycosides are of the holostane type containing a C18 (20) lactone group and either Δ7(8) or Δ9(11) double bond in their genins. The acetoxy group is mainly connected to the C-16, C-22, C-23 and/or C-25 of their aglycone. Apparently, the presence of an acetoxy group, particularly at C-16 of the aglycone, plays a significant role in the bioactivity; including induction of caspase, apoptosis, cytotoxicity, anticancer, antifungal and antibacterial activities of these compounds. This manuscript highlights the structure of acetylated saponins, their biological activity, and their structure-activity relationships.

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Section: Antifungal Activitysupporting

confidence: 91%

Section: Introductionmentioning

confidence: 99%

Acetylated Triterpene Glycosides and Their Biological Activity from Holothuroidea Reported in the Past Six Decades

Bahrami

Franco

2016

Marine Drugs

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“…A. japonicus is believed to contain many biologically and pharmacologically active compounds such as bioactive peptides, essential fatty acids, polysaccharides, and glycoproteins (Abuajah et al 2015;Lee et al 2012;Liu et al 2012b;Wang et al 2012;Yang et al 2015). Especially in recent years, A. japonicus processing industries have developed increasingly fast and become a flourishing economic sector in China (Xu et al 2015).…”

Section: Introductionmentioning

confidence: 99%

Effects of heat treatment on the gel properties of the body wall of sea cucumber (Apostichopus japonicus)

Zhang

Hou

et al. 2017

J Food Sci Technol

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The sensory texture of sea cucumber (Apostichopus japonicus) was dramatically affected by heat treatment. In this study, sea cucumbers were heated under different thermal conditions (HSC), and divided into five groups (HSC-80, HSC-90, HSC-100, HSC-110, and HSC-120) according to the heating temperature (from 80 to 120°C). The changes in texture, moisture, gel structure, and biochemical parameters of the HSC were investigated. With increasing heating time (from 10 to 80 min), the hardness and gel structure changed slightly, and the water activity decreased as the proportion of T 21 increased by 133.33, 55.56, and 59.09% in the HSC-80, HSC-90, and HSC-100 groups, respectively. This indicated that moderate heating conditions (below 100°C) caused gelation of sea cucumbers in HSC-80, HSC-90, and HSC-100 groups. However, as the water activity increased, the hardness declined rapidly by 2.56 and 2.7% in the HSC-110 and HSC-120 groups, with heating time increased from 10 to 80 min. Meanwhile, free hydroxyproline and ammonia nitrogen contents increased by 81.24 and 63.16% in the HSC-110 group; and by 63.09 and 54.99% in the HSC-120 group, as the gel structure of the sea cucumbers decomposed in these two groups. These results demonstrated that, severe heat treatment (above 100°C) destroyed the chemical bonds, triggered the disintegration of collagen fibers and the gel structure of sea cucumbers, and transformed the migration and distribution of moisture, finally causing the deterioration of the sensory texture of the sea cucumbers.

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“…The sea cucumbers have multiple biological activities such as wound healing (Fredalina et al 1999), antibacterial (Gowda et al 2008;Haug et al 2002;Kiani et al 2014;Ridzwan et al 1995), antifungal (Wang et al 2012), agglutinating activities (De Melo et al 2014;Gowda et al 2008) and antioxidant properties (Osama et al 2009). …”

mentioning

confidence: 99%

Bioactivity of aqueous and organic extracts of sea cucumber Holothuria leucospilota (Brandt 1835) on pathogenic Candida and Streptococci

et al. 2018

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Holothurians (sea cucumbers) exist almost in all benthic marine environments and they are an important species for the commercial fisheries. In this study, the antimicrobial activity of different tissues of the sea cucumber, as a marine invertebrate, was investigated. The bacteria, Streptococcus mutans and Streptococcus sobrinus, the fungi, Candida parapsilosis, Candida albicans and Candida glabrata, were chosen for antimicrobial test, because they are opportunistic pathogens. The body wall, respiratory tree, and gastrointestinal tract of the sea cucumbers were utilized to make the extracts. Phosphate-buffered saline (PBS), ethanol (Et), and acetonitrile (ACN) were used as solvents for aqueous and organic extractions. The results showed that there were antimicrobial active compounds against infective streptococci and candid fungi. Streptococcus mutans was generally more tolerant than Streptococcus sobrinus to the sea cucumber extracts. The extracts of the respiratory tree with ACN and PBS, as solvents, showed the highest effect against Candida albicans, Candida parapsilosis and Candida glabrata. The extracts of gastrointestinal tract and the body wall with Et and PBS, respectively, had not any antifungal activity. The antimicrobial activities had been found in different extracts of the sea cucumber tissues, which could be related to the protein and non-protein compounds.

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Antifungal nortriterpene and triterpene glycosides from the sea cucumber Apostichopus japonicus Selenka

Cited by 54 publications

References 17 publications

Acetylated Triterpene Glycosides and Their Biological Activity from Holothuroidea Reported in the Past Six Decades

Acetylated Triterpene Glycosides and Their Biological Activity from Holothuroidea Reported in the Past Six Decades

Effects of heat treatment on the gel properties of the body wall of sea cucumber (Apostichopus japonicus)

Bioactivity of aqueous and organic extracts of sea cucumber Holothuria leucospilota (Brandt 1835) on pathogenic Candida and Streptococci

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