Antifungal mechanisms supporting boric acid therapy of Candida vaginitis

Seta, Francesco De; Schmidt, Martin; Vu, Bao G.; Essmann, Michael; Larsen, Bryan

doi:10.1093/jac/dkn486

Cited by 96 publications

(87 citation statements)

References 16 publications

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“…The mechanism of action of BA against fungi is not yet understood, although some have suggested that it inhibits Candida filamentation [171]. Pointer et al have noted that the selective inhibitory effect of BA on C. albicans hyphae is likely be due to the disruption of apical cytoskeletal elements of growing hyphae [172].…”

Section: Boric Acidmentioning

confidence: 99%

Future therapies targeted towards eliminatingCandidabiofilms and associated infections

Bandara

Matsubara

Samaranayake

2016

Expert Review of Anti-infective Therapy

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Section: Boric Acidmentioning

confidence: 99%

Future therapies targeted towards eliminatingCandidabiofilms and associated infections

Bandara

Matsubara

Samaranayake

2016

Expert Review of Anti-infective Therapy

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“…Additionally, it is used as a pesticide and food preservative against plant fungicides (Turkoglu 2007). BA having antimicrobial activity (De Seta et al 2009), is able to strengthen the tissue antioxidant defenses via a yet unidentified mechanism that may involve changes in oxidative metabolism (Hunt and Idso 1999;Pawa and Ali 2006). BA also shows minimal potential for genotoxicity in bacteria and cultured mammalian cells (Moore and Expert Scientific Comittee 1997).…”

Section: Introductionmentioning

confidence: 99%

Boric acid: a potential chemoprotective agent against aflatoxin b1 toxicity in human blood

Türkez

Geyikoğlu

2010

Cytotechnology

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Aflatoxin B 1 is the most potent pulmonary and hepatic carcinogen. Since the eradication of Aflatoxin B 1 contamination in agricultural products has been difficult, the use of natural or synthetic free radical scavengers could be a potential chemopreventive strategy. Boric acid is the major component of industry and its antioxidant role has recently been reported. The present study assessed, for the first time, the effectiveness of boric acid following exposure to Aflatoxin B 1 on human whole blood cultures. The biochemical characterizations of glutathione and some enzymes have been carried out in erythrocytes. Alterations in malondialdehyde level were determined as an index of oxidative stress. The sister-chromatid exchange and micronucleus tests were performed to assess DNA damages in lymphocytes. Aflatoxin B 1 treatment significantly reduced the activities of antioxidants by increasing malondialdehyde level (30.53 and 51.43%) of blood, whereas, the boric acid led to an increased resistance of DNA to oxidative damage induced by Aflatoxin B 1 in comparison with control values (P \ 0.05). In conclusion, the support of boric acid was especially useful in Aflatoxin-toxicated blood. Thus the risk on tissue targeting of Aflatoxin B 1 could be reduced ensuring early recovery from its toxicity.

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“…La vaginitis por C. krusei suele responder a azoles (excepto fluconazol) y al ácido bórico vaginal. En mujeres gestantes debe evitarse el uso de ácido bórico y anfotericina B [61].…”

Section: Etiología De Las Vulvovaginitis Por Candida (Vvc)unclassified

Candidosis vaginal. Segunda parte:diagnóstico, tratamiento y situación de algunos países latinoamericanos

Uribarren-Berrueta

Pineda-Murillo

Cortés-Figueroa

et al. 2017

Rev. Médica Risaralda

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Las levaduras del género Candida causan enfermedades en los humanos que abarcan desde infecciones superficiales no graves, hasta sistémicas y potencialmente mortales. La candidiasis o candidosis, es el origen común de enfermedad vaginal y aunque es una infección no considerada como incapacitante, suele causar síntomas molestos que alteran la conducta del paciente. En México se considera la única micosis de reporte obligatorio ante las autoridades sanitarias. Por lo anterior, en este trabajo se efectuó una revisión bibliográfica para conocer el estado del arte de la vulvovaginitis causada por Candida spp. (VVC), y ofrecer una breve descripción acerca de la frecuencia presentada por esta infección en diversos países de Latinoamérica, con especial énfasis en México. Se muestra que las frecuencias de VVC en Latinoamérica, son muy parecidas a las reportadas en países como Estados Unidos de América; asimismo, Candida albicans sigue prevaleciendo como el principal agente etiológico. Las diferencias encontradas entre países desarrollados con respecto a los latinoamericanos, consisten básicamente en los métodos diagnósticos y el tipo de tratamiento. Desafortunadamente, en México, a pesar de que la VVC ocupa el noveno lugar entre las 20 principales causas de enfermedad del país, en muy pocos casos se efectúa la identificación de la especie causante, lo que constituye un dato de importancia epidemiológica, considerado como la base para investigar los factores que aumentan el riesgo de contagio, en especial por especies Candida no-albicans y para determinar si la enfermedad es prevenible o controlable.

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Antifungal mechanisms supporting boric acid therapy of Candida vaginitis

Abstract: Boric acid is fungistatic to fungicidal depending on concentration and temperature. Inhibition of oxidative metabolism appears to be a key antifungal mechanism, but inhibition of virulence probably contributes to therapeutic efficacy in vivo.

Cited by 96 publications

References 16 publications

Future therapies targeted towards eliminatingCandidabiofilms and associated infections

Future therapies targeted towards eliminatingCandidabiofilms and associated infections

Boric acid: a potential chemoprotective agent against aflatoxin b1 toxicity in human blood

Candidosis vaginal. Segunda parte:diagnóstico, tratamiento y situación de algunos países latinoamericanos

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