Antifungal limonoids from the fruits of Khaya senegalensis

Abdelgaleil, Samir A. M.; Iwagawa, Tetsuo; Doe, Matsumi; Nakatani, Munehiro

doi:10.1016/j.fitote.2004.06.001

Cited by 55 publications

(50 citation statements)

References 7 publications

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“…Limonoids obtained from some Khaya species, showed good antibacterial and antifungal activity. 53,54) In another study limonoids from several plants belonging to meliaceae as well as rutaceae family were reported to have significant antifungal activity. 53,55,56) In these studies the importance of structural features on activity is also illustrated.…”

Section: )mentioning

confidence: 98%

Limonoids: Overview of Significant Bioactive Triterpenes Distributed in Plants Kingdom

Roy¹,

Saraf

2006

Biological & Pharmaceutical Bulletin

490

276

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The search for limonoids started long back when scientists started looking for the factor responsible for bitterness in citrus which has negative impact on citrus fruit and juice industry worldwide. The term limonoids was derived from limonin, the first tetranortriterpenoid obtained from citrus bitter principles. Compounds belonging to this group have exhibited a range of biological activities like insecticidal, insect antifeedant and growth regulating activity on insects as well as antibacterial, antifungal, antimalarial, anticancer, antiviral and a number of other pharmacological activities on humans. Although hundreds of limonoids have been isolated from various plants but, their occurrence in the plant kingdom is confined to only plant families of order Rutales and that too more abundantly in Meliaceae and Rutaceae, and less frequently in Cneoraceae and Harrisonia sp. of Simaroubaceae. Limonoids are highly oxygenated, modified terpenoids with a prototypical structure either containing or derived from a precursor with a 4,4,8-trimethyl-17-furanylsteroid skeleton. All naturally occurring citrus limonoids contain a furan ring attached to the D-ring, at C-17, as well as oxygen containing functional groups at C-3, C-4, C-7, C-16 and C-17. The structural variations of limonoids found in Rutaceae are less than in Meliaceae and are generally limited to the modification of A and B rings, the limonoids of Meliaceae are more complex with very high degree of oxidation and rearrangement exhibited in the parent limonoid structure. To counter the problem of bitterness in citrus juice and products genetic engineering of citrus to maximize the formation of limonoid glucosides for reducing limonoid bitterness is the focus of recent and future research. Regarding the biological activities of limonoids the investigations are to be directed towards detailed characterization, quantification, and designing a simple as well as versatile synthetic route of apparently important limonoids. Extraction methods too should be optimized; evaluation and establishment of pharmaco-dynamic and kinetic principles, and structure activity relationships should be a key goal associated with limonoids so that they can be safely introduced in our arsenal of pharmaceuticals to safeguard the humanity from the wrath of disease and its discomfort.

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Section: )mentioning

confidence: 98%

Limonoids: Overview of Significant Bioactive Triterpenes Distributed in Plants Kingdom

Roy¹,

Saraf

2006

Biological & Pharmaceutical Bulletin

490

276

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“…4 Limonoids exhibited a wide spectrum of biological properties including cytotoxic, [5][6][7][8] antioxidant, 9,10 antiinammatory, 11,12 neuroprotective, 13,14 antiviral, 15 antimicrobial, 16,17 antiprotozoal, 18 antimalarial, [19][20][21] insect antifeedant, [22][23][24][25][26] and insecticidal activities. [27][28][29] The present review highlights the advances of limonoids in regard to isolation, total synthesis, and structural modications with the relevant biological properties.…”

Section: Introductionmentioning

confidence: 99%

Recent progress in the chemistry and biology of limonoids

Zhang

2017

RSC Adv.

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“…Several authors have also reported the effectiveness of plant products in the management of both insect pests and diseases (Amadioha 1999; Ahmed and Beg 2001; Abdelgaleil and Nakatani 2003; Abdelgaleil et al 2004;Bdliya and Dahiru 2006;. Similarly, the effect of solar heat in controlling potato tuber soft rot has been reported by some authors (Bdliya and Haruna 2007).…”

Section: Discussionmentioning

confidence: 81%

“…Although, there are few reports on the use of mahogany products in controlling plant pathogens, extracts from the plant have been extensively used in the control of insect pests of crops, particularly cotton boll worm (Abdelgaleil et al 2004). A part from the insecticidal properties of mahogany products, these products have also been reported to possess antifungal and bactericidal properties (Abdelgaleil et al 2001;Ademola et al 2004).…”

Section: Discussionmentioning

confidence: 99%

Efficacy of Mahogany Bark Aqueous Extracts and Exposure to Solar Heat for Treatment of Potato Tuber Soft Rot Caused by Erwinia Carotovora Ssp. Carotovora

Bdliya¹,

Abraham²

2010

Journal of Plant Protection Research

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Abstract:The efficacy of combining tuber treatment with mahogany bark aqueous extracts and exposure to solar heat for the control of potato tuber soft rot was investigated. Artificially inoculated potato tubers were treated with mahogany bark aqueous extracts and exposed to solar heat for zero, one, two and three hours. The results showed that tuber treatment with the plant extract followed by exposure to solar heat significantly reduced the incidence and severity of tuber soft rot compared to the control group. However, the highest reduction in the incidence and severity of the disease was recorded on tubers treated with the plant extract and incubated immediately after treatment (no exposure to solar heat). This suggests that the plant extract is more effective at lower than higher temperatures. Potato tuber losses due to soft rot could therefore be managed by tuber treatment with mahogany bark extract and no exposure to solar heat.

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Antifungal limonoids from the fruits of Khaya senegalensis

Cited by 55 publications

References 7 publications

Limonoids: Overview of Significant Bioactive Triterpenes Distributed in Plants Kingdom

Limonoids: Overview of Significant Bioactive Triterpenes Distributed in Plants Kingdom

Recent progress in the chemistry and biology of limonoids

Efficacy of Mahogany Bark Aqueous Extracts and Exposure to Solar Heat for Treatment of Potato Tuber Soft Rot Caused by Erwinia Carotovora Ssp. Carotovora

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