Antifungal Hydrogels: Living Bacteria in Thermoresponsive Gel for Treating Fungal Infections (Adv. Funct. Mater. 40/2018)

Abstract

In article number https://doi.org/10.1002/adfm.201801581, Boaz Mizrahi and co‐workers report an anti‐fungal delivery system based on secreting bacteria inside a thermo‐responsive hydrogel. The formula hardens after administration whereas bacteria continuously produce antifungal agents and deliver them in situ. This system could provide an efficient and safe alternative to traditional fungal infection treatments.

Insights into switchable thermoresponsive copolymer layers by atmospheric pressure plasma‐initiated chemical vapour deposition

“…In particular, polymers that undergo a hydration/dehydration transition when heated, possess a so-called lower critical solution transition (LCST). [1] Over the last few decades, research efforts have been focused on TRP as surface modification layers driven by potential applications including tissue engineering, [2] drug delivery, [3] smart textile fabrication, [4] actuators and sensors for micro-electro-mechanical systems (MEMS), [5] as well as the capture and subsequent release of biomolecules for analytical assays. [6] The immobilization of thin TRP on solid surfaces has already been achieved by different techniques, mainly based on wet chemistries and relying on the grafting-to and grafting-from approaches.…”