Antifungal Effect of Brachyglottis repanda Ethanol Extract

Yook, Chan Nam; Na, Young Soon; Choi, Hee Joung; You, Il Soo; Baek, Jong Min; Baek, Seung Hwa

doi:10.5487/tr.2010.26.2.117

Cited by 2 publications

(2 citation statements)

References 10 publications

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“…It is used to treat sores and wounds [178]. Antifungal [179], antiviral [178], anti-microbial [180], and anti-cancer [178,180] properties were studied. Extraction of plant parts (listed in Table 3) was performed by maceration with ethanol [20] or methanol [21].…”

Section: Brachyglottismentioning

confidence: 99%

Extracting and Analyzing Pyrrolizidine Alkaloids in Medicinal Plants: A Review

Kopp

Abdel‐Tawab

Mizaikoff

2020

Toxins

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Pyrrolizidine alkaloids (PAs) are distributed in plant families of Asteraceae, Boraginaceae, and Fabaceae and serve in the chemical defense mechanism against herbivores. However, they became a matter of concern due to their toxicity associated with the high risk of intake within herbal preparations, e.g., phytopharmaceutical formulations, medicinal teas, or other plant-derived drug products. In 1992, the German Federal Ministry of Health established the first limits of PA content for fourteen medicinal plants. Because of the toxic effects of PAs, the Federal Institute of Risk Assessment (BfR) established more stringent limits in 2011, whereby a daily intake <0.007 µg/kg body weight was recommended and valid until 2018. A threefold higher limit was then advised by BfR. To address consumer safety, there is the need for more efficient extraction procedures along with robust, selective, and sensitive analytical methods to address these concerns. With the increased prevalence of, e.g., phytopharmaceutical formulations, this timely review comprehensively focuses on the most relevant extraction and analysis strategies for each of those fourteen plant genera. While a variety of extraction procedures has been reported, differences in PA content of up to 1110 ppm (0.11% (w/w)) were obtained dependent on the nature of the solvent and the applied extraction technique. It is evident that the efficient extraction of PAs requires further improvements or at least standardization of the extraction conditions. Comparing the various analytical techniques applied regarding selectivity and sensitivity, LC-MS methods appear most suited. This review shows that both standardized extraction and sensitive determination of PAs is required for achieving appropriate safety levels concerning public health in future.

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Section: Brachyglottismentioning

confidence: 99%

Extracting and Analyzing Pyrrolizidine Alkaloids in Medicinal Plants: A Review

Kopp

Abdel‐Tawab

Mizaikoff

2020

Toxins

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“…Clinical assessment was performed though scoring of lesions on 0th, 7th, and 14th days posttreatment according to the method previously described [ 16 , 19 , 20 ]. The main criteria for the evaluation contained three points: inflammation, scale, and hair loss.…”

Section: Methodsmentioning

confidence: 99%

In Vivo Evaluation of Galla chinensis Solution in the Topical Treatment of Dermatophytosis

Sun

Song

Jia

et al. 2017

Evidence-Based Complementary and Alternative Medicine

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Aim Dermatophytosis is one of the main fungal diseases in humans and animals all over the world. Galla chinensis, a traditional medicine, has various pharmacological effects. The goal of this study was to evaluate the treatment effect of Galla chinensis solution (GCS) on dermatophytosis-infected dogs (Microsporum canis, Microsporum gypseum, and Trichophyton mentagrophytes, resp.). Methods The treatment effects of GCS were evaluated by mycological cure rates and clinical score comprised of three indices, including inflammation, hair loss, and lesion scale. Results The results showed that, in the three models of dermatophytosis, GCS significantly (P < 0.05) improved skin lesions and fungal eradication. GCS (10% and 5%) had higher efficacy compared to the positive control (Tujingpi Tincture). The fungal eradication efficacy exceeds 85% after treatment with GCS (10%, 5%, and 2.5%) on day 14. Conclusion The GCS has antidermatophytosis effect in dogs, which may be a candidate drug for the treatment of dermatophytosis.

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Antifungal Effect of Brachyglottis repanda Ethanol Extract

Cited by 2 publications

References 10 publications

Extracting and Analyzing Pyrrolizidine Alkaloids in Medicinal Plants: A Review

Extracting and Analyzing Pyrrolizidine Alkaloids in Medicinal Plants: A Review

In Vivo Evaluation of Galla chinensis Solution in the Topical Treatment of Dermatophytosis

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