Antifungal drugs

Cartwright, R. Y.

doi:10.1093/jac/1.2.141

Cited by 23 publications

(6 citation statements)

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“…Nevertheless, penetration of amphotericin B into many body sites, including the CSF, is poor; and the symptomatic and objective side-effects of this drug may be severe, renal impairment in particular being almost invariable with effective treatment (Bennett, 1974a). Flucytosine is better tolerated and less toxic (Cartwright, 1975) and penetrates well into most body spaces, and successful cures have been reported in the literature . Failures of treatment, and relapse after apparently successful treatment, are common with both drugs (Utz et al, 1975).…”

Section: Discussionmentioning

confidence: 99%

Cryptococcal meningitis complicating systemic lupus erythematosus: two patients treated with flucytosine and amphotericin B.

Speller¹,

Fakunle²,

Cairns³

et al. 1977

J Clin Pathol

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SUMMARY Two fatal cases of cryptococcal meningitis complicating adrenocorticosteroid-treated systemic lupus erythematosus are reported. In one patient who was treated with flucytosine alone, after an initial period of improvement cryptococci resistant to flucytosine were isolated, and subsequent amphotericin B treatment did not alter the progress of the disease. In the second patient, who received both drugs concurrently, resistant cryptococci did not appear and the patient recovered sufficiently to return home. Flucytosine-resistant mutants could be demonstrated in vitro in the original cryptococcal isolates from both patients. The use of flucytosine and amphotericin B in combination is discussed.

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Section: Discussionmentioning

confidence: 99%

Cryptococcal meningitis complicating systemic lupus erythematosus: two patients treated with flucytosine and amphotericin B.

Speller¹,

Fakunle²,

Cairns³

et al. 1977

J Clin Pathol

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“…Amphotericin B alone diffuses poorly into the cerebrospinal fluid, its concentration in which is only one-fourth of that in the serum, whereas the concentration of 5-fluorocytosine in the spinal fluid is about three-fourth ofthat in serum. The combination ofthese drugs for their synergistic effect is recommended for the therapy of cryptococcosis infection especially when the central nervous system is involved (2,3,4,10,12,14,24,26).…”

Section: Discussionmentioning

confidence: 99%

Disseminated Cutaneous Cryptococcosis

Thianprasit

2009

Mycoses

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Summary: A case of primary cutaneous cryptococcosis in a Thai woman with impairment of cellular immunity is reported. The infection later metastasized to different parts of the body resulting in various cutaneous lesions. With the presence of cryptococcus cells in the spinal fluid, there were no neurological manifestations. The infection was successfully treated with the combination of amphotericin B and 5‐fluorocytosine. Zusammenfassung: Bericht über einen Fall einer primären cutanen Cryptococcose bei einer thailändischen Frau mit einer gestörten zellulären Immunität. Später metastasierte die Infektion in verschiedene Körperregionen, wodurch zahlreiche cutane Herde entstanden. Trotz Gegenwart von Cryptococcus‐Zellen im Liquor cerebrospinalis bestanden keine neurologischen Symptome. Die Infektion wurde erfolgreich mit einer Kombination von Amphotericin B und 5‐Fluorocytosin behandelt.

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“…Aspergillus and Candida species are considered the major fungal agents involved in ocular infections [6], The three principal groups of antimycotics currently available for use in nondermatophyte infections [2], the polyenes, the imidazoles and 5-fluorocytosine, could, therefore, be considered for treatment of ocular infections [9],…”

Section: Introductionmentioning

confidence: 99%

Miconazole Activity in Experimental Aspergillus Ocular Infections

Segal¹,

Romano²,

Barishak³

1981

Ophthalmic Res

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The invitro and invivo activity of miconazole in Aspergillus ocular infections was studied. The invitro susceptibility to miconazole of stock cultures of 5 pathogenic Aspergillus species and of 10 Aspergillus strains isolated from human ocular infections was assayed, revealing that the Aspergillus strains were sensitive invitro to miconazole. The invivo activity of miconazole was assayed in 45 rabbits with experimental A. fumigatus ocular infections, which were treated with miconazole, administered topically and/or systemically, to test the drug’s capability to cure or prevent infections. Neither the topical nor the systemic nor combined treatments resulted in a cure or significant improvement of the severe ocular infections. However, infections could be prevented by pretreatment with miconazole prior to infection or treatment together with the inoculation of the infective agent.

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Antifungal drugs

Cited by 23 publications

References 0 publications

Cryptococcal meningitis complicating systemic lupus erythematosus: two patients treated with flucytosine and amphotericin B.

Cryptococcal meningitis complicating systemic lupus erythematosus: two patients treated with flucytosine and amphotericin B.

Disseminated Cutaneous Cryptococcosis

Miconazole Activity in Experimental Aspergillus Ocular Infections

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