Antifungal drug solubilizing activity and self-aggregation ability of cationic aminocalix[4]arene in comparison to SBEβCD: effect of addition of water-soluble polymer

Supramolecular systems based on amidoammonium and amidoaminocalix[4]resorcinarenes and polyacrylic acid

“…The charges' neutralization in the systems with the macrocycles bearing peripheral primary and tertiary amino groups, which are partially protonated in the aqueous media, leads to the formation of the water-insoluble (at neutral pH) complexes with PAA. The immobilization mode of macrocycle on the PAA includes the formation of complex with monomers (non-aggregated macrocycle 1) or with the macrocycle' aggregates (2)(3)(4)(5)(6)(7)(8)(9)(10) and was investigated by using their associates with the MO dye. Macrocycle 1 forms the inclusion complex with MO, the dye molecules are competitively displaced in aqueous solution during interaction of the hydrophilic groups of macrocycle with PAA.…”

“…The supramolecular cyclodextrin-polymer systems, based on this property, have been extensively studied since the early 90s. The noncovalent binding of the cyclodextrin by the functionalized polymers leads to a sharp increase in the viscosity of their solutions and to formation of hydrogels, which exhibit biocompatibility, sensitive to the external stimuli and are of interest as the drug-delivery systems and as components of the engineered tissues [9,10,12].…”

“…This feature was used to form the drug-delivery system on the basis of the supramolecular aggregate hydroxypropyl-methylcellulosetrimethylammoniomethyl tetrapropoxycalix [4]arene. This system was used for the solubilizing the water-insoluble antifungal drugs (clotrimazole and econazole nitrate) [10]. It was shown that the interaction of the macrocycle' aggregates with the nonionic polymer leads to the increase in the size of aggregates and as a result the solubilization ability of the system is increased.…”

Intercomparing different devices for the investigation of ice nucleating particles using Snomax<sup>®</sup> as test substance

“…For that, measurements were done with a StabiSizer (Microtrac Europe GmbH, PMX 200CS). A detailed description of the instruments and its applications can be found in Ukhatskaya et al (2014). In short, the diameter of the fragments was determined from measurements of scattered light at an angle of 180 • .…”

Encapsulation of Drug Molecules into Calix[n]arene Nanobaskets. Role of Aminocalix[n]arenes in Biopharmaceutical Field

“…However, maximum solubility enhancement was observed for steroid drugs. Later, better solubilizing ability of 45 in comparison with sulfobutyl ether beta‐cyclodextrin toward antifungal drugs was observed at the same concentration range . The solubilizing properties of aminocalix[4]arene‐folate conjugate 149 toward the nonsteroidal anti‐inflammatory drug indomethacin has been investigated .…”