Antifungal drug resistance pattern of Candida. spp isolated from vaginitis in Ilam-Iran during 2013-2014

Mohamadi, Jasem; Havasian, Mohamad Reza; Panahi, Jafar; Pakzad, Iraj

doi:10.6026/97320630011203

Cited by 22 publications

(18 citation statements)

References 33 publications

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“…The findings revealed that the prevalence of Candida vaginitis was 160 (51.6%). These results are similar to Mohamadi et al (17), Hedayati et al (15), and Rasti et al's studies (18). Furthermore, the present study indicated the high rate of VVC in 30-to 40-year-olds, which is in agreement with the study of Mohamadi et al (17), while it is in contrast with Rezaei-Matekolaei et al (19).…”

Section: Discussionsupporting

confidence: 92%

Identification of Candida Species Isolated from Vulvovaginal Candidiasis Patients by Polymerase Chain Reaction-Restriction Fragment Length Polymorphism (PCR-RFLP) in Yasuj Southwestern Iran

Gharaghani

Ahmadi

Sisakht

et al. 2018

Jundishapur J Microbiol

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Background: Vulvovaginal candidiasis (VVC) is a frequent infection in females at the reproductive age. Furthermore, the most common causative agent is Candida albicans yet in the recent years, the incidence of non-albicans species has increased. Objectives: The main aim of this study was the isolation and identification of various Candida species from patients with vulvovaginal candidiasis by polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) in Yasuj, Iran. Methods: Three hundred and ten suspected women females vaginitis were sampled and examined. Genomic DNA was extracted from fresh colonies by phenol-chloroform glass bead methods. Polymerase chain reaction (PCR) amplification was performed based on the ribosomal DNA internal transcribed spacer (rDNA-ITS), and specific electrophoretic patterns of PCR products after digestion with MspI enzyme used for species identification. Results: The cultures were positive for 160 (51.6%) vaginal samples. Candida albicans (86.8%) was the most common species among the isolates, followed by C. glabrata (3.77%) and C. krusei (3%). Multispecies with two Candida were identified in nine patients. Conclusions: Vulvovaginal candidiasis is more prevalent among females in Yasuj and the predominant agent is C. albicans. In addition, correct identification of Candida species could play an important role in management and treatment of VVC.

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Section: Discussionsupporting

confidence: 92%

Identification of Candida Species Isolated from Vulvovaginal Candidiasis Patients by Polymerase Chain Reaction-Restriction Fragment Length Polymorphism (PCR-RFLP) in Yasuj Southwestern Iran

Gharaghani

Ahmadi

Sisakht

et al. 2018

Jundishapur J Microbiol

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“…In the present study, a different frequency of VVC (39.76%) was reported when compared to our previous studies in Ahvaz in 2016 (28.3%) and 2010 (49%) (15,21). The frequency of VVC in other cities in Iran was reported as 62.1%, 43.3%, 40%, 26%, and 4.8% from Ilam, Babol, Arak, Hamadan, and Zanjan, respectively (12,13,16,31,32).…”

Section: Discussionmentioning

confidence: 98%

Prevalence of Vulvovaginal Candidiasis in Ahvaz, Southwest Iran: A Semi-Large Scale Study

Kiasat

Rezaei‐Matehkolaei

Mahmoudabadi

et al. 2019

Jundishapur J Microbiol

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Background: Candida vaginitis or vulvovaginal candidiasis (VVC) is the most common mucosal infection of the female genital tract caused by different species of Candida. Despite several antifungal therapies and personal hygiene practices, VVC has remained an important public health problem affecting millions of women worldwide. Objectives: The aim of this study was to determine the prevalence of VVC and the frequency of causative agents in women of different age groups referring to the midwifery clinics in Ahvaz, Iran, from January 2017 to March 2018. Methods: Samples were obtained from 493 women aged 15-64 years with signs and symptoms of VVC using endocervical swabs. All collected samples were cultured on CHROMagar Candida plates and incubated at 35°C for 24-72 h. Various Candida sp. were initially identified using morphologic characteristics and physiologic features, and finally confirmed with PCR-RFLP. Results: Totally 196 (39.76%) cases were diagnosed as VVC, of which nine (4.6%) were as recurrent vulvovaginal candidiasis. More than half of the cases were in the age group of 21-30 years. Candida albicans was the most commonly identified species (71.1%), followed by C. glabrata (20.4%) and other non-C. albicans species (8.6%). Infection in pregnant women decreased in the third trimester compared to the first and second trimesters of pregnancy. Conclusions: Vulvovaginal candidiasis is a relatively common gynecologic problem in Ahvaz. Although the frequency of non-C. albicans species in VVC has increased, C. albicans is still the predominant species.

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“…Pregnancy, contraception drugs with high estrogen, antibiotic consumptions, uncontrolled diabetes, immunosuppressive drugs, unsafe or excessive sexual intercourse, chronic anemia and season allergy are some predisposing factors of VC. The most common signs of VC are vaginal itching, dysuria and malodorous-white vaginal secretions [ 4 ]. Treatment of VC varies substantially and the most common drugs used are azole agents [ 5 ].…”

Section: Introductionmentioning

confidence: 99%

Antifungals susceptibility pattern of Candida spp. isolated from female genital tract at the Yaoundé Bethesda Hospital in Cameroon

Kengne¹,

Shu²,

Nwobegahay³

et al. 2017

Pan Afr Med J

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IntroductionVaginal candidiasis is considered as an important public health problem worldwide and its incidence has increased nowadays. In recent years, inappropriate and disproportionate use of antifungal drugs, automedication as well as non compliance have caused drug resistance.MethodsThis study aimed at determining the in vitro antifungal susceptibility patterns of Candida speciesisolated from female genital tract at Yaoundé Bethesda Hospital in Cameroon. Two hundred and fourthy five women (age range: 15 years to 49 years) attending the hospital were recruited between January and June 2014 in this cross sectional study. Vaginal smears were collected using sterile swabs from each participant and cultured on sabouraud dextrose agar supplemented with chloramphenico l 0.5%; identification of Candida spp. was performed following standard methods. The disk diffusion method was used for antifungal susceptibility testing.ResultsOut of the 245 vaginal smears collected, 94 (38.4%) strains of yeast were isolates among which 43 (45.7%) were Candida albicans and 51 (54.3%) were non albicans. The highest susceptibility of the isolates was seen for nystatin 62 (83.78%), ketoconazole 61 (82.43%) and fluconazole 60 (81.08%).ConclusionDespite the noticeable resistance of Candida spp. isolates to miconazole and itraconazole, the results indicate that nystatin, ketoconazole and fluconazole are the drugs of choice for the therapy of vaginal candidiasis in this region.

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Antifungal drug resistance pattern of Candida. spp isolated from vaginitis in Ilam-Iran during 2013-2014

Cited by 22 publications

References 33 publications

Identification of Candida Species Isolated from Vulvovaginal Candidiasis Patients by Polymerase Chain Reaction-Restriction Fragment Length Polymorphism (PCR-RFLP) in Yasuj Southwestern Iran

Identification of Candida Species Isolated from Vulvovaginal Candidiasis Patients by Polymerase Chain Reaction-Restriction Fragment Length Polymorphism (PCR-RFLP) in Yasuj Southwestern Iran

Prevalence of Vulvovaginal Candidiasis in Ahvaz, Southwest Iran: A Semi-Large Scale Study

Antifungals susceptibility pattern of Candida spp. isolated from female genital tract at the Yaoundé Bethesda Hospital in Cameroon

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