Antifungal and biofilm inhibitory effect of Cymbopogon citratus (lemongrass) essential oil on biofilm forming by Candida tropicalis isolates; an in vitro study

Şahal, Gülcan; Woerdenbag, Herman J.; Hinrichs, Wouter L. J.; Visser, Anita; Tepper, Pieter G.; Quax, Wim J.; Mei, Henny C. van der; Bilkay, Işıl Seyis

doi:10.1016/j.jep.2019.112188

Cited by 68 publications

(43 citation statements)

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“…The EO of C. limon presented an MIC of 500 μL/mL for C. tropicalis [ 40 ], while there were inhibition halos reported between 15.3 and 16.3 mm when they tested C. limonum by cylinder-plate diffusion [ 34 ]; in contrast, there were inhibition halos ranging from 4.44 to 10.87 mm when using EO of C. sinensis and C. latifolia by agar diffusion [ 37 ] ( Table 2 ). EOs of C. reticulata, C. aurantium, C. nobilis , C. sinensis, C. hystix , and C. grandis have shown an MIC ranging from 1,000 μg/mL to values greater than 4,000 μg/mL by microdilution in broth [ 11 , 21 ].…”

Section: Resultsmentioning

confidence: 99%

“…Citrus EOs have also been evaluated for their ability to inhibit and eradicate preformed biofilms. The EO of C. limon eradicated 70% or more of the C. tropicalis biofilm at concentrations starting from 0.125 x MIC (MIC equal to 500 μL/mL) [ 40 ]. Other reports show that 125 μg/mL and 250 μg/mL of the EO of C. limon , respectively, were able to inhibit and eradicate the biofilm of C. krusei [ 11 ].…”

Section: Resultsmentioning

confidence: 99%

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Essential Oils of Melaleuca, Citrus, Cupressus, and Litsea for the Management of Infections Caused by Candida Species: A Systematic Review

et al. 2021

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Candida is a common agent of infection in humans, which has a wide distribution and is a colonizer fungus of the body, occasionally assuming the role of a pathogen. The type of treatment depends on the site of infection and the clinical condition of the patient. Superficial infections, such as mucosal infections, can be treated with topical medications. So-called alternative therapies have rarely been studied, although the literature records the effectiveness of some treatments, especially as complementary therapy. The aims of this review were to analyze evidence of the anti-Candida inhibitory activity of essential oils of the Citrus, Cupressus, Litsea, and Melaleuca species; in addition to addressing the chemical composition, probable mechanisms of antifungal action and studies of toxicity, cytotoxicity, and genotoxicity were included. The literature from Medline/PubMed, Science Direct, Scopus, Web of Science, and the Brazilian database Periodic Capes was reviewed. Thirty-eight articles were selected, which included two articles on Litsea spp., seven on Cupressus spp., thirteen articles on Citrus spp., and twenty-one articles on Melaleuca spp. In conclusion, this study showed in vitro evidence for the use of essential oils of the plant species evaluated for the treatment of infections caused by different Candida species.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Essential Oils of Melaleuca, Citrus, Cupressus, and Litsea for the Management of Infections Caused by Candida Species: A Systematic Review

et al. 2021

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“…The utilization of natural components derived ideally from plants or microbes themselves has shown impressive results on biofilm control. In clinical settings, natural components such as essential oils [171], biopeptides [172], biosurfactants [173], plant extracts [174,175], plant-based nanoparticles [176,177], and so forth, have been used as potent biofilm inhibiting agents. Karlapudi et al [178] enhanced biofilm eradication by targeting quorum sensing whilst minimizing the risk of multiple drug resistance development in biofilm-forming microbes.…”

Section: Recent Developments In Eradication Of Biofilms In the Health And Food Sectormentioning

confidence: 99%

Microbial biofilm: A matter of grave concern for human health and food industry

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Pathogenic microorganisms have adapted different strategies during the course of time to invade host defense mechanisms and overcome the effect of potent antibiotics. The formation of biofilm on both biotic and abiotic surfaces by microorganisms is one such strategy to resist and survive even in presence of antibiotics and other adverse environmental conditions. Biofilm is a safe home of microorganisms embedded within self‐produced extracellular polymeric substances comprising of polysaccharides, extracellular proteins, nucleic acid, and water. It is because of this adaptation strategy that pathogenic microorganisms are taking a heavy toll on the health and life of organisms. In this review, we discuss the colonization of pathogenic microorganisms on tissues and medically implanted devices in human beings. We also focus on food spoilage, disease outbreaks, biofilm‐associated deaths, burden on economy, and other major concerns of biofilm‐forming pathogenic microorganisms in food industries like dairy, poultry, ready‐to‐eat food, meat, and aquaculture.

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“…The MBEC 50 of fennel oil for eradicating the 18-h-old biofilm was 2- to 16-fold of MIC, in 7/10 tested strains. Sahal et al [ 132 ] investigated the antifungal and biofilm inhibitory effects of EOs by using C. tropicalis biofilms coated on different biomaterials. Treatments with 2%–8% of C. citratus EO coated on silicone rubber resulted in a 45%–76% reduction in biofilm formation of all the strains.…”

Section: Reported Antibiofilm Activities Of Eos Propolis and Extracts From Plants Algae And Cyanobacteriamentioning

confidence: 99%

Fungal Biofilms as a Valuable Target for the Discovery of Natural Products That Cope with the Resistance of Medically Important Fungi—Latest Findings

et al. 2021

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The development of new antifungal agents that target biofilms is an urgent need. Natural products, mainly from the plant kingdom, represent an invaluable source of these entities. The present review provides an update (2017–May 2021) on the available information on essential oils, propolis, extracts from plants, algae, lichens and microorganisms, compounds from different natural sources and nanosystems containing natural products with the capacity to in vitro or in vivo modulate fungal biofilms. The search yielded 42 articles; seven involved essential oils, two Brazilian propolis, six plant extracts and one of each, extracts from lichens and algae/cyanobacteria. Twenty articles deal with the antibiofilm effect of pure natural compounds, with 10 of them including studies of the mechanism of action and five dealing with natural compounds included in nanosystems. Thirty-seven manuscripts evaluated Candida spp. biofilms and two tested Fusarium and Cryptococcus spp. Only one manuscript involved Aspergillus fumigatus. From the data presented here, it is clear that the search of natural products with activity against fungal biofilms has been a highly active area of research in recent years. However, it also reveals the necessity of deepening the studies by (i) evaluating the effect of natural products on biofilms formed by the newly emerged and worrisome health-care associated fungi, C. auris, as well as on other non-albicans Candida spp., Cryptococcus sp. and filamentous fungi; (ii) elucidating the mechanisms of action of the most active natural products; (iii) increasing the in vivo testing.

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Antifungal and biofilm inhibitory effect of Cymbopogon citratus (lemongrass) essential oil on biofilm forming by Candida tropicalis isolates; an in vitro study

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Cited by 68 publications

References 51 publications

Essential Oils of Melaleuca, Citrus, Cupressus, and Litsea for the Management of Infections Caused by Candida Species: A Systematic Review

Essential Oils of Melaleuca, Citrus, Cupressus, and Litsea for the Management of Infections Caused by Candida Species: A Systematic Review

Microbial biofilm: A matter of grave concern for human health and food industry

Fungal Biofilms as a Valuable Target for the Discovery of Natural Products That Cope with the Resistance of Medically Important Fungi—Latest Findings

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