Antifungal and Antioxidant Activities of the Essential Oil from Angelica koreana Nakai

Abstract

Purpose. The purpose of this study is to determine the antifungal and antioxidant activities of the essential oil from Angelica koreana. Methods. Essential oil was obtained from the dried roots of A. koreana by steam distillation, and its composition was identified by gas chromatography and mass spectrometry (GC-MS). The minimal inhibitory concentrations (MICs) of the oil fraction and its main components were determined by broth dilution assay using common pathogenic Aspergillus and Trichophyton species. The combined effects of the oils with itraconazole were evaluated using a checkerboard titer test. In addition, 1,1-diphenyl-2-picryl-hydrazil (DPPH) free radical scavenging, nitrite inhibition, and reducing power were determined to assess the antioxidant activity of this oil. Results. The essential oil fraction and its main components showed inhibitory activity against all of the tested fungi, with minimal inhibitory concentrations (MICs) of 250–1000 μg/mL. Furthermore, this oil exhibited synergism when combined with itraconazole. Conclusion. In the treatment of infections caused by Aspergillus and Trichophyton species, combining itraconazole with either A. koreana essential oil or its main components may reduce the minimum effective dose of itraconazole required and, thus, minimize its side effects. In addition, this oil is a promising source of natural antioxidant agents.

Chemical Composition and In Vitro Antimicrobial Efficacy of Sixteen Essential Oils against Escherichia coli and Aspergillus fumigatus Isolated from Poultry

“…Its composition is characterized by a 24% of sabinene, 36.7% of limonene and 12% of citronellal. The antifungal activity is probably due to sabinene, which appeared effective against A. fumigatus [ 32 ], as well as to citronellal [ 33 ]. Moreover, the present data are in full agreement with Correa-Royero et al [ 34 ], who reported effectiveness against A. fumigatus at 99.2 µg/mL.…”

A Review of the Composition of the Essential Oils and Biological Activities of Angelica Species

“…m -Cresol (56.12%) showed stronger DPPH scavenging activity than EO (19.31%) and sabinene (4.45%) at the concentration of 16 mg/mL. Additionally, sabinene exhibited the strongest reducing power and nitric oxide scavenging activities than the EO fraction or m -cresol [ 36 ]. Irshad et al [ 24 ] reported that A. glauca EO exhibited good DPPH radical scavenging and peroxidation inhibition activities.…”

“…A. koreana EO and its main components, sabinene and m -cresol, showed antifungal activity against different species of Aspergillus and Trichophyton with minimal inhibitory concentrations (MICs) of 125–1000 μg/mL. In addition, EO exhibited synergistic activity when combined with itraconazole [ 36 ]. The EO of A. glauca showed appreciable antimicrobial activity against selected strains of bacteria ( Staphylococcus aureus , Bacillus subtilis , Escherichia coli, and Pasteurella multocida ) and fungi ( Candida albicans , Microsporum canis , Aspergillus flavus, and Fusarium solani ).…”

Chemical Composition and Antioxidant and Antibacterial Activities of an Essential Oil Extracted from an Edible Seaweed, Laminaria japonica L.

“…Accordingly, many plants and their products, particularly essential oils, have recently been tested for their potential antioxidant activity against adverse free radicals [6,13,14,15]. Essential oils extracted from plants have become a good source of natural antioxidants [16]. Moreover, there is growing interest in the use of marine organisms as a potential source of effective antimicrobial and antioxidant compounds [17].…”