Antifungal Agents from <i>Pseudallescheria boydii</i> SNB-CN73 Isolated from a <i>Nasutitermes</i> sp. Termite

Nirma, Charlotte; Éparvier, Véronique; Stien, Didier

doi:10.1021/np4001703

Cited by 50 publications

(52 citation statements)

References 21 publications

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“…Microorganisms. The antimicrobial activity of the essential oils was investigated against the Gram-negative bacterial strain Escherichia coli ATCC 25922, the Gram-positive bacterial strain Staphylococcus aureus ATCC 29213, the yeast Candida albicans ATCC 10231, and a clinical isolate of the dermatophyte Trichophyton rubrum SNB-TR1 [21].…”

Section: Experimental Partmentioning

confidence: 99%

Chemical Composition and Antimicrobial Activity of the Essential Oil of Juniperus excelsa M.Bieb. Growing Wild in Lebanon

Khoury

Beyrouthy

Ouaini

et al. 2014

Chemistry & Biodiversity

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The essential oils (EOs) isolated from the leaves and twigs of Juniperus excelsa M.Bieb. growing wild in Lebanon were characterized, and their antimicrobial activity and antiradical capacity were evaluated. The EOs were obtained by hydrodistillation using a Clevenger-type apparatus and characterized by GC and GC/MS analyses. The antimicrobial activity was evaluated by determining minimal inhibitory concentrations (MICs) against a Gram-positive and a Gram-negative bacterium, a yeast, and a dermatophyte with the broth microdilution technique. A total of 28 constituents was identified and accounted for 90.1 and 95.6% of the twig and leaf EO composition, respectively. Both EOs were essentially composed of monoterpene hydrocarbons (46.7 and 59.6% for twig and leaf EOs, resp.) and sesquiterpenes (39.4 and 32.1%, resp.). The main components were α-pinene, α-cedrol, and δ-car-3-ene. The J. excelsa EOs did not show any antiradical potential, but revealed interesting in vitro antimicrobial activities against Staphylococcus aureus and Trichophyton rubrum (MICs of 64 and 128 μg/ml, resp.). The three major compounds were tested separately and in combination according to their respective amounts in the oil. δ-Car-3-ene was the most active component and is undoubtedly one of the constituents driving the antifungal activity of J. excelsa essential oil, even though synergies are probably involved.

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Section: Experimental Partmentioning

confidence: 99%

Chemical Composition and Antimicrobial Activity of the Essential Oil of Juniperus excelsa M.Bieb. Growing Wild in Lebanon

Khoury

Beyrouthy

Ouaini

et al. 2014

Chemistry & Biodiversity

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“…Pseudallescheria boydii is deemed to be a human pathogenic fungus and can cause a variety of infections, especially in the immunocompromised and immunocompetent patients. However, up to now, the literature reports on the secondary metabolites of this fungus are still limited [8,9,10,11,12,13]. The literature survey prompted us to investigate the metabolites of the fungus, Pseudallescheria boydii .…”

Section: Introductionmentioning

confidence: 99%

Pseudaboydins A and B: Novel Isobenzofuranone Derivatives from Marine Fungus Pseudallescheria boydii Associated with Starfish Acanthaster planci

et al. 2014

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Two novel isobenzofuranone derivatives, pseudaboydins A (1) and B (2), along with five known compounds, including (R)-2-(2-hydroxypropan-2-yl)-2,3-dihydro-5-hydroxybenzofuran (3), (R)-2-(2-hydroxypropan-2-yl)-2,3-dihydro-5-methoxybenzofuran (4), 3,3′-dihydroxy-5,5′-dimethyldiphenyl ether (5), 3-(3-methoxy-5-methylphenoxy)-5-methylphenol (6) and (−)-regiolone (7), were isolated from the culture broth of the marine fungus, Pseudallescheria boydii, associated with the starfish, Acanthaster planci. Their structures were elucidated primarily based on NMR and MS data. The absolute configurations of 1–4 were determined by CD spectroscopy and single-crystal X-ray diffraction studies. The cytotoxic and antibacterial activities of 1–4 were evaluated. Pseudaboydin A (1) showed moderate cytotoxic activity against human nasopharyngeal carcinoma cell line HONE1, human nasopharyngeal carcinoma cell line SUNE1 and human glandular lung cancer cell line GLC82 with IC50 values of 37.1, 46.5 and 87.2 μM, respectively.

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“…(Carr et al 2012) Furthermore, continuous research on the secondary metabolites of termite-associated actinomycetes from Macrotermes natalensis colonies led to the isolation of a highly modified geldanamycin compound, natalamycin A (17) (Kim et al 2014), and the antifungal compounds, tyroscherin and N-methyltyroscherin (18), were identified in a Pseudallescheria boydii fungal strain isolated from the termite Nasutitermes sp. in France (Nirma et al 2013). In addition, rare actinomycete Amycolatopsis from the grasshopper Oxya chinensis was found to produce new tetrasaccharides, that is, the actinotetraoses A (19)-K (Guo et al 2012(Guo et al , 2013.…”

Section: Chemical Biology Of Gut Bacteria and Their Secondary Metabolmentioning

confidence: 98%

Considerations of the chemical biology of microbial natural products provide an effective drug discovery strategy

Choi

2015

Arch. Pharm. Res.

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Conventional approaches to natural product drug discovery rely mainly on random searches for bioactive compounds using bioassays. These traditional approaches do not incorporate a chemical biology perspective. Searching for bioactive molecules using a chemical and biological rationale constitutes a powerful search paradigm. Here, the authors review recent examples of the discovery of bioactive natural products based on chemical and biological interactions between hosts and symbionts, and propose this method provides a more effective means of exploring natural chemical diversity and eventually of discovering new drugs.

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Antifungal Agents from Pseudallescheria boydii SNB-CN73 Isolated from a Nasutitermes sp. Termite

Cited by 50 publications

References 21 publications

Chemical Composition and Antimicrobial Activity of the Essential Oil of Juniperus excelsa M.Bieb. Growing Wild in Lebanon

Chemical Composition and Antimicrobial Activity of the Essential Oil of Juniperus excelsa M.Bieb. Growing Wild in Lebanon

Pseudaboydins A and B: Novel Isobenzofuranone Derivatives from Marine Fungus Pseudallescheria boydii Associated with Starfish Acanthaster planci

Considerations of the chemical biology of microbial natural products provide an effective drug discovery strategy

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