Antifungal Activity on the Water Extracts of Five Fagaceae Plants

Moon, Sang-Ho; Song, Chang-Khil; Kim, Tae-Keun; Oh, Dong-Eun; Kim, Hyoun-Cho

doi:10.11625/kjoa.2017.25.2.295

Korean J. org. Agric.

2017

DOI: 10.11625/kjoa.2017.25.2.295

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Antifungal Activity on the Water Extracts of Five Fagaceae Plants

Sang-Ho Moon¹,

Chang-Khil Song²,

Tae-Keun Kim³

et al.

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Cited by 2 publications

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Acetylcholinesterase and monoamine oxidase-B inhibitory activities by ellagic acid derivatives isolated from Castanopsis cuspidata var. sieboldii

Jang

Kang

et al. 2021

Sci Rep

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Among 276 herbal extracts, a methanol extract of Castanopsis cuspidata var. sieboldii stems was selected as an experimental source for novel acetylcholinesterase (AChE) inhibitors. Five compounds were isolated from the extract by activity-guided screening, and their inhibitory activities against butyrylcholinesterase (BChE), monoamine oxidases (MAOs), and β-site amyloid precursor protein cleaving enzyme 1 (BACE-1) were also evaluated. Of these compounds, 4′-O-(α-l-rhamnopyranosyl)-3,3′,4-tri-O-methylellagic acid (3) and 3,3′,4-tri-O-methylellagic acid (4) effectively inhibited AChE with IC50 values of 10.1 and 10.7 µM, respectively. Ellagic acid (5) inhibited AChE (IC50 = 41.7 µM) less than 3 and 4. In addition, 3 effectively inhibited MAO-B (IC50 = 7.27 µM) followed by 5 (IC50 = 9.21 µM). All five compounds weakly inhibited BChE and BACE-1. Compounds 3, 4, and 5 reversibly and competitively inhibited AChE, and were slightly or non-toxic to MDCK cells. The binding energies of 3 and 4 (− 8.5 and − 9.2 kcal/mol, respectively) for AChE were greater than that of 5 (− 8.3 kcal/mol), and 3 and 4 formed a hydrogen bond with Tyr124 in AChE. These results suggest 3 is a dual-targeting inhibitor of AChE and MAO-B, and that these compounds should be viewed as potential therapeutics for the treatment of Alzheimer’s disease.

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Acetylcholinesterase and monoamine oxidase-B inhibitory activities by ellagic acid derivatives isolated from Castanopsis cuspidata var. sieboldii

Jang

Kang

et al. 2021

Sci Rep

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Plus Tree Selection of Quercus salicina Blume and Q. glauca Thunb. and Its Implications in Evergreen Oaks Breeding in Korea

Kim

Lee

Shim

et al. 2020

Forests

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This study was conducted to select plus trees of two evergreen oaks, Quercus salicina and Q. glauca, in Korea. Evergreen oaks are distributed in subtropical region in Korea and have recently emerged as one of the alternative tree species against climate change. Accordingly, a tree breeding program is underway to foster evergreen oaks as a reforestation species for the future. Through intensive survey on the distribution range, 15 stands (8 for Q. salicina, 3 for Q. glauca, and 4 for both species) were selected as base populations. To select candidate trees, we developed a subjective grading system with six characteristics in three categories and introduced a weighted generalized value (GVIw) to compare superiority of candidate trees. The candidate trees were screened using baseline value ‘0’, i.e., if GVIw > 0, then accepted and if GVIw < 0, then rejected. After then, adjustment was conducted to avoid biasing the selection of plus trees for a particular location. Through this process, 44 candidate trees in Q. salicina and 41 candidate trees in Q. glauca were selected as plus trees. Finally, the results and implications were discussed in relation to evergreen oak breeding in Korea.

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Antifungal Activity on the Water Extracts of Five Fagaceae Plants

Cited by 2 publications

References 0 publications

Acetylcholinesterase and monoamine oxidase-B inhibitory activities by ellagic acid derivatives isolated from Castanopsis cuspidata var. sieboldii

Acetylcholinesterase and monoamine oxidase-B inhibitory activities by ellagic acid derivatives isolated from Castanopsis cuspidata var. sieboldii

Plus Tree Selection of Quercus salicina Blume and Q. glauca Thunb. and Its Implications in Evergreen Oaks Breeding in Korea

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