Antifungal activity of water-stable copper-containing metal-organic frameworks

Abstract

Although metal-organic frameworks (MOFs) or porous coordination polymers have been widely studied, their antimicrobial activities have not yet been fully investigated. In this work, antifungal activity of copper-based benzene-tricarboxylate MOF (Cu-BTC MOF), which is water stable and industrially interesting, is investigated against Candida albicans, Aspergillus niger, Aspergillus oryzae and Fusarium oxysporum. The Cu-BTC MOF can effectively inhibit the growth rate of C. albicans and remarkably inhibit the spore growth of A. niger, A. oryzae and F. oxysporum. This finding shows the potential of using Cu-BTC MOF as a strong biocidal material against representative yeasts and moulds that are commonly found in the food and agricultural industries.

Green-synthesized copper nanoparticles as a potential antifungal against plant pathogens

“…21 In contrast, it has been reported that microparticles of copper-containing metal-organic frameworks at concentrations as high as 0.5 mg mL À1 caused 50% of inhibition of F. oxysporum. 19 Summarizing, concentrations of the green-synthesized Cu-NPs higher than 0.75 mg mL À1 inhibit almost completely the growth of the three evaluated fungi with IRG near the 100%. As a sake of comparison, for the growth inhibition of F. solani, 1.2 mg mL À1 of chitosan NPs (size 200-433 nm) were needed.…”

“…36 Similar effects have been reported for Cu-NPs used against Aspergillus niger, Aspergillus oryzae, and Fusarium oxysporum. 19 At a concentration of 0.25 mg mL À1 of Cu-NPs, F. solani and F. oxysporum clearly exhibit cell surface damage, such as loss of cell wall integrity and morphological changes that include inammation of cells ( Fig. 4c and 6c).…”

“…Similar results have been reported for the antifungal activity of copper nanoparticles against different fungi. 19,27 Higher concentrations of Cu-NPs in the growth media promote greater IRG (smaller colony areas), see Fig. 2.…”

“…16,17 It has been reported that Cu-NPs act as a fungicide against a number of species of plant pathogenic fungi such as Fusarium sp., Phoma destructiva, Curvularia lunata, Alternaria alternate, Fusarium oxysporum, Penicillium italicum, Penicillium digitatum and, Rhizoctonia solani. [18][19][20][21] To the best of our knowledge, the antifungal activity of Cu-NPs against pathogenic fungi that affect crop and forests species has not been investigated fully. Here we present the antifungal properties of Cu-NPs against three species of plant pathogenic fungi.…”

In situ deposition of MOF199 onto hierarchical structures of bamboo and wood and their antibacterial properties

“…14 MOF199, which is water-stable, has been proved to possess powerful antibacterial activity by inducing damage to the bacterial envelope. [15][16][17] Abbasi et al rst reported the antimicrobial activity of MOF199 coated on silk against Escherichia coli (E. coli) and Staphylococcus aureus (S. aureus). 18 Further study by RodrÍguez et al found that a cellulose-MOF showed high antibacterial activity in both solid and liquid cultures, and copper ions did not leach from the coated fabric.…”