Antifungal activity of the volatiles of Agathosma betulina and Coleonema album commercial essential oil and their effect on the morphology of fungal strains Trichophyton rubrum and T. mentagrophytes

Fajinmi, Olufunke O.; Kulkarni, Manoj G.; Benická, Sandra; Zeljković, Sanja Ćavar; Doležal, Karel; Tarkowski, Petr; Finnie, J.F.; Staden, J. Van

doi:10.1016/j.sajb.2018.03.003

Cited by 14 publications

(6 citation statements)

References 41 publications

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“…The hyphae and spores of T. rubrum were also destroyed due to the volatile effects. The major components identified in A. betulina EO are limonene (29.8%), menthone (21.6%), and isomenthone (14.7%), while pinene (27.4%) and myrcene (14.5%) makes up the major part of C. album [ 69 ]. In the formulation of skincare products, the C. album (Thunb) Bart.…”

Section: Discussionmentioning

confidence: 99%

Antifungal Properties of Essential Oils and Their Compounds for Application in Skin Fungal Infections: Conventional and Nonconventional Approaches

et al. 2021

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Essential oils (EOs) are known to have varying degrees of antimicrobial properties that are mainly due to the presence of bioactive compounds. These include antiviral, nematicidal, antifungal, insecticidal and antioxidant properties. This review highlights the potential of EOs and their compounds for application as antifungal agents for the treatment of skin diseases via conventional and nonconventional approaches. A search was conducted using three databases (Scopus, Web of Science, Google Scholar), and all relevant articles from the period of 2010–2020 that are freely available in English were extracted. In our findings, EOs with a high percentage of monoterpenes showed strong ability as potential antifungal agents. Lavandula sp., Salvia sp., Thymus sp., Citrus sp., and Cymbopogon sp. were among the various species found to show excellent antifungal properties against various skin diseases. Some researchers developed advanced formulations such as gel, semi-solid, and ointment bases to further evaluate the effectiveness of EOs as antifungal agents. To date, most studies on the application of EOs as antifungal agents were performed using in vitro techniques, and only a limited number pursued in vivo and intervention-based research.

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Section: Discussionmentioning

confidence: 99%

Antifungal Properties of Essential Oils and Their Compounds for Application in Skin Fungal Infections: Conventional and Nonconventional Approaches

et al. 2021

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“…After the release of the active component, the active component acts against the fungal infection by following different mechanisms, such as an oil that inhibits the growth of a fungus by inserting emulsions in the fungus cell wall where the oil emulsions can cause respiration inhibition and can destroy the cell wall of the fungus hyphae, resulting in cell death, while the oil helps to cure the infection [160]. On the other hand, volatile essential oils inhibit spore formation, such as in a study by Fajinmi et al (2019) showed the effect of 40 μL Agathosma betulina essential oil against the Trichophyton rubrum species. These species can produce hyphae that can penetrate the host's skin and cause an infection inside the skin.…”

Section: Antifungal Mechanism Of Essential Oil and Plant Extract-base...mentioning

confidence: 99%

Natural and Synthetic Bioactives for Skin Health, Disease and Management

2022

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Madison through the cutaneous and cancer biology and chemoprevention program. Since 2017, as a ULM COP faculty member, he has established a research program on collaborative cutaneous biology, molecular dermatology, and experimental therapeutics. With expertise in the tissue engineering of normal and diseased human skin, murine models of disease, and new pharmacological and oncolytic viral therapies, Dr. Chamcheu is currently researching the interplay between disease targets, immunity, cancer, and interventions based on dietary bioactive ingredients, as well as synthetic scaffolds and oncolytic viruses, in the development, prevention, and treatment of chronic inflammatory skin diseases and cancer to promote health. He has authored over 41 peer-reviewed publications and book chapters, edited books, and supervised and trained several students, scientists, and fellows. He has received several awards from the American Skin Association, SID, PC, IJMS, LBRN, and the Louisiana Board of Regents.

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“…After the release of the active component, the active component acts against the fungal infection by following different mechanisms, such as an oil that inhibits the growth of a fungus by inserting emulsions in the fungus cell wall where the oil emulsions can cause respiration inhibition and can destroy the cell wall of the fungus hyphae, resulting in cell death, while the oil helps to cure the infection [160]. On the other hand, volatile essential oils inhibit spore formation, such as in a study by Fajinmi et al (2019) showed the effect of 40 µL Agathosma betulina essential oil against the Trichophyton rubrum species. These species can produce hyphae that can penetrate the host's skin and cause an infection inside the skin.…”

Section: Antifungal Mechanism Of Essential Oil and Plant Extract-base...mentioning

confidence: 99%

“…Essential oils and herbal extracts have antifungal properties because their phenolic groups act as the primary antimicrobial bioactive compound [138][139][140][141][142]. Phenolic groups are complex, volatile, aromatic compounds with different chemical structures and are stored in various parts of the plant, in particular tissue such as glandular hairs, oil cells, and oil ducts [143]. They are now well known due to their antimicrobial, germ-killing, antiinflammatory, and antioxidant properties [144].…”

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A Review on Antifungal Efficiency of Plant Extracts Entrenched Polysaccharide-Based Nanohydrogels

et al. 2021

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Human skin acts as a physical barrier; however, sometimes the skin gets infected by fungi, which becomes more severe if the infection occurs on the third layer of the skin. Azole derivative-based antifungal creams, liquids, or sprays are available to treat fungal infections; however, these formulations show various side effects on the application site. Over the past few years, herbal extracts and various essential oils have shown effective antifungal activity. Additionally, autoxidation and epimerization are significant problems with the direct use of herbal extracts. Hence, to overcome these obstacles, polysaccharide-based nanohydrogels embedded with natural plant extracts and oils have become the primary choice of pharmaceutical scientists. These gels protect plant-based bioactive compounds and are effective delivery agents because they release multiple bioactive compounds in the targeted area. Nanohydrogels can be applied to infected areas, and due to their contagious nature and penetration power, they get directly absorbed through the skin, quickly reaching the skin’s third layer and effectively reducing the fungal infection. In this review, we explain various skin fungal infections, possible treatments, and the effective utilization of plant extract and oil-embedded polysaccharide-based nanohydrogels.

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Antifungal activity of the volatiles of Agathosma betulina and Coleonema album commercial essential oil and their effect on the morphology of fungal strains Trichophyton rubrum and T. mentagrophytes

Cited by 14 publications

References 41 publications

Antifungal Properties of Essential Oils and Their Compounds for Application in Skin Fungal Infections: Conventional and Nonconventional Approaches

Antifungal Properties of Essential Oils and Their Compounds for Application in Skin Fungal Infections: Conventional and Nonconventional Approaches

Natural and Synthetic Bioactives for Skin Health, Disease and Management

A Review on Antifungal Efficiency of Plant Extracts Entrenched Polysaccharide-Based Nanohydrogels

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