Antifungal activity of the aqueous extract of Ilex paraguariensis against Malassezia furfur

Abstract

Malassezia furfur is a lipodependent, dimorphic and saprophyte fungus which causes pityriasis versicolor, dandruff and seborrheic dermatitis in humans. The drugs available to treat this fungal infection are few. These drugs are highly toxic and are costly when used in prolonged treatments. For these reasons, it is necessary to find new compounds to treat these infections. Ilex paraguariensis St Hilaire is a plant that grows in Argentina, Brazil and Paraguay. The aim of this study was to evaluate the effect of the aqueous extract of Ilex paraguariensis on the growth of M. furfur. High performance liquid chromatography (HPLC) was employed to identify and isolate compounds of I. paraguariensis and the agar-well diffusion method was used to assess the antifungal activity of the extract. The fungicidal/fungistatic effect was evaluated by the modified Thompson assay. The results demonstrated that the aqueous extract of Ilex paraguariensis (1000 mg/ml) possesses inhibitory activity against M. furfur. This antimalassezial activity was equivalent to 2.7 microg/ml of ketoconazole. Therefore, the topical use of Ilex paraguariensis extract as alternative antifungal agent can be suggested.

Composition and Bioactive Properties of Yerba Mate (llex paraguariensis A. St.-Hil.): A Review

“…Relatively limited research has been conducted on isolation and identification of compounds possessing antimicrobial activity derived from yerba mate (Kubo et al, 1993;Hongpattarakere, 2000;Sari et al, 2007;Tsai et al, 2008;Filip et al, 2010). Filip et al (2010) identified caffeoyl derivatives, methylxanthines, and rutin from yerba mate aqueous extracts with antifungal activity.…”

“…Filip et al (2010) identified caffeoyl derivatives, methylxanthines, and rutin from yerba mate aqueous extracts with antifungal activity. N-hexane extracts of yerba mate have been shown to be effective antimicrobial agents against the oral bacterium, Streptococcus mutans (Kubo et al, 1993).…”

Potencial Terapêutico de Espécies Arbóreas em Fragmentos de Floresta Ombrófila Mista

“…Desempenha importante papel socioeconômico nos estados de Santa Catarina, Rio Grande do Sul, Paraná e Mato Grosso do Sul (Wendling et al, 2009), onde tem sido explorada na forma natural, consorciada a outras espécies florestais ou intercalada com culturas anuais (Dedecek & Rodigheri, 1999). Dentre as propriedades medicinais estudos relatam os efeitos do extrato de I. paraguariensis como agente antifúngico (Filip et al, 2010), atividade de inibição e inativação bacteriana (Girolometto et al, 2009), com potencial inibitório contra enzimas chave relevantes para hiperglicemia (Ranilla et al, 2010), como diurético (Gonzalez et al, 1993), efeitos antioxidantes (Gugliucci, 1996) 11 Ochwang'i et al (2014). 12 Cosenza et al (2013).…”

Avaliação Da Atividade Antimicrobiana Do Óleo Volátil E Extratos Etanólicos De Folhas E Ramos De Ilex Paraguariensis A. St.-Hil. (Erva-Mate)

“…Vários estudos sugerem que o consumo dos produtos oriundos da erva-mate apresentam atividade antioxidante, antiobesidade, antidiabética, estimulante e capacidade diurética (Filip et al, 2010, Pagliosa 2010Yu et al, 2015). Pesquisas vêm demonstrando a atividade antibacteriana e antifúngica da erva-mate e a necessidade de maiores estudos (Burris et al, 2011;Cornellas et al, 2011;Petrović et al, 2012).…”