Antifungal activity of the Algerian<i>Lawsonia inermis</i>(henna)

Rahmoun, Mohammed Nadjib; Boucherit-Otmani, Z.; Boucherit, K.; Benabdallah, Mohammed; Choukchou‐Braham, Noureddine

doi:10.3109/13880209.2012.715166

Cited by 63 publications

(44 citation statements)

References 19 publications

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“…The extract of leaves of L. inermis has been shown to possess antimicrobial activity [4]. Ethanolic extract of the whole plant was found to have antifungal activity [5].…”

Section: Introductionmentioning

confidence: 99%

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Antimicrobial Activities of the Henna Extract and Some Synthetic Naphthoquinones Derivatives

Rahmoun¹,

Boucherit-Atmani²,

Benabdallah³

et al. 2013

AJMBR

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Naphthoquinones are compounds widely distributed in the environment, both as natural products and as pharmaceutical agents. They have been the subject of much research due to their pharmacological activities. In this study, methanol extract of henna and a series of synthesized structural analogue of lawsone have been assessed for their antimicrobial activities. Methanol extract of henna and eight naphthoquinones derivatives were tested as potential antimicrobial agents against twelve bacteria and three Candida species using the agar disc diffusion and broth microdilution methods according to guidelines recommended by the Clinical and Laboratory Standards Institute. Besides 2b and 3b, methanol extract and all the synthesized compounds 1a, 2a, 1b and 1c, 2c and 3c showed weakto-strong activity against at least one tested strain. However, the compounds 1c and 1b were found to have the most effective activity against pathogenic bacteria and displayed an activity 8 to 64 fold higher than that othe structural analogue, lawsone. Their MICs ranged from 8-64 µg ml -1. Henna extract was found to have an interesting activity. Our results indicate an effective in vitro activity of 1,4-naphthoquinone derivatives and suggest the benefits of further studies for its application in antibiotherapy.

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“…The extract of leaves of L. inermis has been shown to possess antimicrobial activity [4]. Ethanolic extract of the whole plant was found to have antifungal activity [5].…”

Section: Introductionmentioning

confidence: 99%

“…(henna) would indicate the probable involvement of lawsone, i.e. 2-hydroxynaphthoquinone, which is known to be the main bioactive constituent of this herb, in the antimicrobial activity [5,8]. …”

mentioning

confidence: 99%

Antimicrobial Activities of the Henna Extract and Some Synthetic Naphthoquinones Derivatives

Rahmoun¹,

Boucherit-Atmani²,

Benabdallah³

et al. 2013

AJMBR

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“…However, they have different mechanisms from antibiotics for inhibiting bacterial growth and also unknown effects on living cells; this makes additional researches on medicinal plants essential (19,20).…”

Section: Discussionmentioning

confidence: 99%

“…Lawsone, the major bioactive component of henna, is known for its antibacterial activity and possesses a wider spectrum of activity (19,23). Also, phenols are responsible for the antimicrobial efficiency of mint (3,9).…”

Section: Discussionmentioning

confidence: 99%

Henna, An Antimicrobial Herbal Medicine With Less Negative Effect on Spermatogonial Stem Cell Culture

et al. 2016

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Background: Herbal extracts have recently received the greatest attention in the path of finding naturally occurring chemicals with antibacterial and therapeutic value; however, each type of herbal remedy may have its own side effects. Objectives:The aim of the current experiment was to study the antibacterial effect of myrtle, parsley, mint, henna and chamomile extracts on Escherichia coli and their effects on colony formation and survival of spermatogonial stem cells (SSCs). Materials and Methods: Spermatogonial stem cells were isolated by two-time enzymatic digestion from slaughterhouse origin ovine testis and plant extraction by deionized water. Comparisons between different treatments were performed using analysis of variance (ANOVA) followed by Duncan's multiple range tests. Results:The results showed that there was no significant difference between mint, henna and penicillin, on inhibition of Escherichia coli growth, however parsley, myrtle and chamomile were significantly different from penicillin (P < 0.05). The formation of SSC colonies was not affected by different herbal medicines. Myrtle and chamomile resulted in death of SSC colonies compared with the control, and the survival of spermatogonial and Sertoli cells were significantly affected by myrtle, mint, chamomile and parsley (P < 0.05). Conclusions:The results of these experiments provide evidence that henna by antibacterial activity had no detrimental affect on SSC and Sertoli cells and is a good candidate for substitution of antibiotics.

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“…The plant has been scientifically proven have antidiabetic, immunomodulatory, hepatoprotective, antioxidant, antibacterial, antifungal, molluscicidal, nootropic, analgesic and anti-inflammatory and cytotoxic activity. [8][9][10][11][12][13][14][15] However the anticonvulsant activity has not been thoroughly investigated scientifically. Hence our present study has been undertaken to evaluate the anticonvulsant activity of Lawsonia innermis leaves.…”

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confidence: 99%

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2016

IJPSR

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ABSTRACT:The aim of the study was to determine the anticonvulsant activity of methanolic extract of Lawsonia inermis leaves in albino rats. The anticonvulsant activity of methanolic extract of leaves of Lawsonia inermis (200 mg/kg and 400 mg/kg) was assessed in rats using maximum electroshock seizure (MES) test and pentylenetetrazole (PTZ) induced seizure test. The methanolic extract of Lawsonia inermis leaves significantly (p<0.01) reduced the hind limb tonic extension in the MES test in a dose dependent manner. In the PTZ model also, the extract signicantly (p<0.01) reduced the duration of clonic convulsions as well as delay the onset of seizures in a dose dependent manner. The study demonstrates that Lawsonia inermis has significant anticonvulsant activity possibly through a GABA-ergic interaction.

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Antifungal activity of the AlgerianLawsonia inermis(henna)

Abstract: These results suggest that the Algerian L. inermis plant has antifungal activity that can be related to the presence of lawsone in the leaves plant. The results can be exploited largely in research of new antifungal drugs.

Cited by 63 publications

References 19 publications

Antimicrobial Activities of the Henna Extract and Some Synthetic Naphthoquinones Derivatives

Antimicrobial Activities of the Henna Extract and Some Synthetic Naphthoquinones Derivatives

Henna, An Antimicrobial Herbal Medicine With Less Negative Effect on Spermatogonial Stem Cell Culture

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