Antifungal activity of the alcoholic extract of coconut shell — Cocos nucifera Linn.

Venkataraman, S.; Ramanujam, T.; Venkatasubbu, Venkatakrishnan

doi:10.1016/s0378-8741(80)81007-5

Cited by 19 publications

(15 citation statements)

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“…The husk fiber showed antifungal activity (Venkataraman et al, 1980). Cocos nucifera was used to overcome the nerves pains in Cameroon (Dibong et al, 2011).…”

Section: Cocos Nuciferamentioning

confidence: 99%

African palm ethno-medicine

Gruca

Blach‐Overgaard

Balslev

2015

Journal of Ethnopharmacology

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“…The husk fiber showed antifungal activity (Venkataraman et al, 1980). Cocos nucifera was used to overcome the nerves pains in Cameroon (Dibong et al, 2011).…”

Section: Cocos Nuciferamentioning

confidence: 99%

African palm ethno-medicine

Gruca

Blach‐Overgaard

Balslev

2015

Journal of Ethnopharmacology

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“…The methanolic extract of the husk of Cocos nucifera has also been reported to have produced in vitro antimicrobial activity against all strains of Staphylococcus aureus tested [ 8 ]. Extract from this plant also showed antifungal activity against Microsporum canis, M. gypseum, M. audouinii, Trichophyton mentagrophytes, T. rubrum, T. tonsurans and T. violaceum [ 9 ]. It also exhibited anti-nociceptive and anti-inflammatory activities which confirm the popular use of this plant in several inflammatory disorders as reported by Rinaldi and co-workers [ 10 ].…”

Section: Introductionmentioning

confidence: 99%

Probable mechanisms of biocidal action of Cocos nucifera Husk extract and fractions on bacteria isolates

Akinpelu

Alayande

Aiyegoro

et al. 2015

BMC Complement Altern Med

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BackgroundThe incidence of resistance to the existing antibiotics by microorganisms demand increased effort in the development of new antibiotics for the treatment of microbial infections and diseases. Infections due to multidrug resistant pathogens are difficult to manage due to relatively limited choices of antimicrobial agents. This study investigated antimicrobial activities of the husk extract of Cocos nucifera on some bacteria that are associated with human diseases.MethodsPowdered husk of Cocos nucifera was cold extracted using mixture of methanol and distilled water in ration 3:2 (v/v). Extract was partitioned into n-hexane. Chloroform, ethylacetate and n-butanol fractions and thereafter, the minimum inhibitory concentrations (MICs) of the extract and those of the fractions were determined. The ethylacetate fraction was found to be more active and was partially purified by a combination of thin-layer and column chromatography. Finally, the rate of killing, leakages of proteins, potassium ions and nucleotides from the tests bacterial cells were determined.ResultsThe minimum Inhibitory concentrations (MICs) of the extract ranged between 0.39 and 12.50 mg/ml and those of the fractions ranged between 0.16 and 5.00 mg/ml. The time-kill assay revealed a minimum of 27.8% killed at 1 × MIC after 15 min contact time with the fractions and a minimum of 95% killed after 120 min.Varying amount of proteins, potassium ions as well as nucleotides were leaked from selected bacterial isolates by the four active fractions. The amount of proteins leaked from the cells after 15 min contact time ranged between 3.56 and 19.08 μg/ml at 1 × MIC and between 10.97 and 19.54 μg/ml at 2 × MIC. The amount of potassium ions leaked from the cells after 15 min contact time ranged between 0.182 and 0.379 mg/ml at 1 × MIC and between 0.227 and 0.561 mg/ml at 2 × MIC. The nucleotides leaked from the cells after 15 min contact time ranged between 0.609 and 2.446 μg/ml at 1 × MIC and between 0.897 and 2.841 μg/ml at 2 × MIC.ConclusionsThis study established the possibility of developing antimicrobial agents of natural origin to combat resistance to antimicrobial compounds by some pathogens currently being experienced in agricultural and health care environments.

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“…On the African continent, C. nucifera ranked third, representing high diversity of medicinal applications (Gruca et al ., ). In fact, the efficacy of traditional uses of C. nucifera has been validated in a number of studies (Venkataraman, Ramanujam & Venkatasubbu, ; Alviano et al ., ; Rinaldi et al ., ). Therefore, knowledge of its medicinal values could be driven by abundance and general awareness of its healing properties.…”

Section: Discussionmentioning

confidence: 99%

Medicinal palms (Arecaceae) in Madagascar-undocumented or underutilized?

et al. 2016

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Palms (Arecaceae) are conspicuous in traditional medicine in Africa, contributing to health care of rural and urban dwellers. Palm species richness in Africa is much lower than in either tropical America or tropical Asia, whereas palm species richness in Madagascar is among the highest in the world when its area is taken into consideration. The African continent is 50 times larger than Madagascar, but has only 65 species of palms, whereas Madagascar in a much smaller area has three times as many species of palms. The objective of this survey was to gather all published ethnobotanical data on medicinal uses of palms in Madagascar and to compare this with the extent of palm use in continental Africa. Information on medicinal uses of palms in Madagascar was found in only 13 published references. We found 55 medicinal use records for at least 17 palm species, of which 14 were endemic to Madagascar and three were introduced. The most used palm was Cocos nucifera, followed by Raphia farinifera. For most of the species, however, we found only a single medicinal use. There are many parts of Madagascar yet to be explored for palms. Further studies and collecting trips may generate a more complete picture and suggest answers to why (or if) there are so few medicinal uses of palms in Madagascar compared to other parts of the world.

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Antifungal activity of the alcoholic extract of coconut shell — Cocos nucifera Linn.

Cited by 19 publications

References 1 publication

African palm ethno-medicine

African palm ethno-medicine

Probable mechanisms of biocidal action of Cocos nucifera Husk extract and fractions on bacteria isolates

Medicinal palms (Arecaceae) in Madagascar-undocumented or underutilized?

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