Antifungal activity of some Tanzanian plants used traditionally for the treatment of fungal infections

Hamza, Omar J M; Beukel, Carolien J. P. van den Bout-van den; Matee, Mecky; Moshi, Mainen J.; Mikx, F. H. M.; Selemani, Haji O.; Mbwambo, Zakaria H.; Ven, A.J.A.M. van der; Verweij, Paul E.

doi:10.1016/j.jep.2006.04.026

Cited by 150 publications

(114 citation statements)

References 41 publications

(43 reference statements)

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“…C. anisata a threatened South African shrub, is one of such plants used by the herbalist and traditional healers for the treatment/management of a wide variety of diseases such as; ulceration of lungs, excessive cough, tuberculosis skin infections, ulcers, sores and other bacterial infections (Hamza et al, 2006, Lawal et al, 2014.…”

Section: Resultsmentioning

confidence: 99%

The antibacterial activity of <i>Clausena anisata</i> hook, a South African medicinal plant

Lawal¹,

Grierson²,

Afolayan³

2015

Afr. J. Trad. Compl. Alt. Med.

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Background: Clausena anisata Hook also known as Iperepesi in Xhosa language is a medicinal plant used traditionally for the treatment of various ailments and some opportunistic infections associated with tuberculosis (TB). Patients in South Africa based on the phytotherapeutic information on this species in the Eastern Cape, use this medicinal plant. Hence, the antibacterial activity of various solvent extracts of the leaves and barks were respectively, evaluated using selected bacterial strains. Method: The leaves and stem bark were tested against 10 selected strains of Gram -positive and Gram -negative bacteria through the agar dilution method. Acetone, dichloromethane and water extracts were used for the extraction. MIC was determined at different concentrations (0.1mg/ml, 0.5mg/ml, 1mg/ml and 5mg/ml) and the results obtained were compared to that of standard antibiotics. Result: The acetone extract of the leaves were more active against both Gram-positive and Gram -negative bacteria with MIC ranging from 0.1 mg/ml -0.5 mg / ml. The dichloromethane extract of the bark showed appreciable activities against Staphylococcus aureus (ATCC 6538) (MIC: 0.1mg /ml) Escherichia coli and, Streptococcus pyogenes with an MIC of 5mg/ml respectively. On the other hand, the aqueous extract of the leaves showed no activity against the tested organisms with the exception of the aqueous bark extract which inhibited Staphylococcus aureus (MIC: 0.5mg/ml) and Pseudomonas aeruginosa (MIC: 5mg/ml). Conclusion: This study confirmed the antibacterial activities of acetone extract of the leaves of Clausena anisata. The capability of this extract to inhibit both Gram positive and negative bacteria is an indication that the extract is a potential broad spectrum antibacterial. The result of this study further justified its indigenous use for the treatment of bacteria commonly associated with TB especially among the people of Nkonkobe Municipality.

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Section: Resultsmentioning

confidence: 99%

The antibacterial activity of <i>Clausena anisata</i> hook, a South African medicinal plant

Lawal¹,

Grierson²,

Afolayan³

2015

Afr. J. Trad. Compl. Alt. Med.

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“…This treatment is documented here for the first time, with a high Significant Use Level (32.9 %). According to Germosén-Robineau (1995), with this Significance Level, the antimycotic use deserves evaluation and scientific validation, as has been done for other species, such as Jatropha multifida L., whose latex was demonstrated to have anti-fungal activity, that is highly effective for more than one strain of fungus (Hamza et al, 2006). Anti-fungal activity against Sporothrix schenckii and Fusarium proliferatum has also been demonstrated in crude extracts from underground parts of J. isabellei (Kieling-Fröhlich et al, 2013).…”

Section: Discussionmentioning

confidence: 99%

“…The active ingredients of the latex of several species have been demonstrated to be hemostatic (Osoniyi & Onajobi, 2003;Oduola, Adeosun, Oduola, Avwioro, & Oyeniyi, 2005), antibacterial (Aiyelaagbe, Adesogan, Ekundayo, & Adeniyi, 2000;Canales et al, 2005), antifungal (Hamza et al, 2006), anti-malarial and anti-parasitic (Baraguey, Blond, Correia, Pousset, Bodo, & Auvin-Guette, 2000), and insecticidal (Bullangpoti, Khumrungsee, Pluempanupat, Kainoh, & Saguanpong, 2011). Extensive reviews in medicinal purposes have been documented for J. curcas (Reddy-Prasad, Izam, & Rahman-Khanwe, 2012) and for J. gossypiipholia (Félix-Silva et al, 2014).…”

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confidence: 99%

Traditional uses and seed chemical composition of Jatropha spp. (Euphorbiaceae) in Tehuacán-Cuicatlán, México

Hernández-Nicolás

Córdova-Téllez

Romero-Manzanares

et al. 2017

RBT

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Jatropha spp. plants are used in traditional medicine, food and for the elaboration of biofuel. The Tehuacán-Cuicatlán Biosphere Reserve in México holds genetic richness and endemism for this genus, but the specific use of the plants and the seed chemical profiles are still unknown. The objectives of this research were to record the traditional forms of use of Jatropha species, and to analyze the chemical composition of Jatropha spp. seeds. For this, a semi-structured survey was conducted in 15 towns, and 20 interviews were applied in each one between May and August 2012. Data allowed to estimate the Significant Use Level and Relative Use Value per species. Besides, seeds from J. neopauciflora, J. rufescens, and J. rzedowskii were collected between August and October 2013, and to seed flour samples we determined total lipids by the Soxhlet method, crude protein by the Kjendahl method, and ashes according to AOAC methods; fatty acid profile and phorbol esters were determined by gas chromatography and by HPLC, respectively. We recorded that the species J. neopauciflora, J. oaxacana, J. rufescens, J. ciliata, and J. rzedowskii, are used as traditional medicine, food, and ornaments, except for J. ciliata, for which none use was recorded. The Significant Use Level as food was found not significant, but for medicinal purposes, J. neopauciflora obtained the highest Relative Use Value (9.0 %). The latex is used to treat 13 disorders, including dental problems (toothache, sensitivity, caries), oral diseases (oral herpes, gingivitis, and oral candidiasis) with a Significant Use Level of 32.9 %; it is also used as a hemostatic. The protein content among species varied from 23.37 to 26.06 %, and total lipids from 34.79 to 36.60 %. The principal unsaturated fatty acids were oleic (25.08 to 30.09 %) and linoleic (44.55 to 48.46 %), and the saturated fatty acids were palmitic (10.11 to 16.50 %) and stearic (9.47 to 11.15 %). Phorbol esters, the main cause of seed’s toxicity, were absent in J. neopauciflora, J. rufescens, and J. rzedowskii. In conclusion, the Significant Use Level of Jatropha species studied was low, with little cultural acceptance and sporadic utilization. The Relative Use Value was important for medicinal purposes, especially for J. neopauciflora. The dehulled seeds of J. neopauciflora, J. rufescens, and J. rzedowskii are potentially useful as food, having high protein contents, and unsaturated oleic and linoleic fatty acids. With this study we report three non-toxic Jatropha species and recommend to scientifically validate the antimycotic use of J. neopauciflora latex.

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“…They were confirmed by ID 32 C carbon assimilation profiles, read and interpreted by the mini API system (Biomerieux). In vitro antifungal susceptibility of all confirmed isolates was determined by broth microdilution method [2] for amphotericin B (AMB), 5-fluorocytosine (5FC), fluconazole, ketoconazole, voriconazole and itraconazole. The mating types of strains were determined as described by Yan et al [3].…”

Section: Methodsmentioning

confidence: 99%

Epidemiology of Cryptococcal Meningitis Associated with HIV in an Indian Hospital

Duggal¹,

Duggal²,

Hans³

et al. 2014

Epidemiol

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Cryptococcus neoformans is an emerging pathogen especially in the setting of HIV infected patients with meningitis. The infection usually manifests in patients with impaired cell mediated immunity. Forty six culture positive cases of cryptococcal meningitis were identified over a period of three years from a tertiary care institute in Delhi. The patients were predominantly males (91%) of reproductive age group, mostly residing in and around Delhi. Most significant co-infections were HIV infection in 93% and tuberculosis in 43.5% cases. All forty six strains belonged to Cryptococcus neoformans var grubii, molecular type VN I, mating type α (MAT α). There was 100% susceptibility to amphotericin B and azoles, one isolate was resistant to 5-fluorocytosine (MIC 64 µg/ml). Cerebrospinal fluid in symptomatic HIV patients should be carefully screened for Cryptococcus spp. which should be identified and also typed for epidemiological purposes.

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Antifungal activity of some Tanzanian plants used traditionally for the treatment of fungal infections

Cited by 150 publications

References 41 publications

The antibacterial activity of <i>Clausena anisata</i> hook, a South African medicinal plant

The antibacterial activity of <i>Clausena anisata</i> hook, a South African medicinal plant

Traditional uses and seed chemical composition of Jatropha spp. (Euphorbiaceae) in Tehuacán-Cuicatlán, México

Epidemiology of Cryptococcal Meningitis Associated with HIV in an Indian Hospital

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