Antifungal activity of salaceyin A against <i>Colletotrichum orbiculare</i> and <i>Phytophthora capsici</i>

Park, C N; Lee, D; Kim, W; Hong, Young-Shick; Ahn, Jong Seog; Kim, B S

doi:10.1002/jobm.200710325

Cited by 9 publications

(5 citation statements)

References 22 publications

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“…Antibacterial (Maruyama et al, 1975 et al, 1993) Salaceyin A A-254 Cytotoxic (Kim et al, 2006), antifungal (Park et al, 2007) Salaceyin B A-254 Cytotoxic (Kim et al, 2006), antifungal (Park et al, 2007) (Songia et al, 1997;Williamson et al, 2006) Virginiamycin M2…”

Section: Taxonomic Identification and Phylogenetic Analyses Of Bioactive Isolatesmentioning

confidence: 99%

Bioactive Natural Products in Actinobacteria Isolated in Rainwater From Storm Clouds Transported by Western Winds in Spain

et al. 2021

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Actinobacteria are the main producers of bioactive natural products essential for human health. Although their diversity in the atmosphere remains largely unexplored, using a multidisciplinary approach, we studied here 27 antibiotic producing Actinobacteria strains, isolated from 13 different precipitation events at three locations in Northern and Southern Spain. Rain samples were collected throughout 2013–2016, from events with prevailing Western winds. NOAA HYSPLIT meteorological analyses were used to estimate the sources and trajectories of the air-mass that caused the rainfall events. Five-day backward air masses trajectories of the diverse events reveals a main oceanic source from the North Atlantic Ocean, and in some events long range transport from the Pacific and the Arctic Oceans; terrestrial sources from continental North America and Western Europe were also estimated. Different strains were isolated depending on the precipitation event and the latitude of the sampling site. Taxonomic identification by 16S rRNA sequencing and phylogenetic analysis revealed these strains to belong to two Actinobacteria genera. Most of the isolates belong to the genus Streptomyces, thus increasing the number of species of this genus isolated from the atmosphere. Furthermore, five strains belonging to the rare Actinobacterial genus Nocardiopsis were isolated in some events. These results reinforce our previous Streptomyces atmospheric dispersion model, which we extend herein to the genus Nocardiopsis. Production of bioactive secondary metabolites was analyzed by LC-UV-MS. Comparative analyses of Streptomyces and Nocardiopsis metabolites with natural product databases led to the identification of multiple, chemically diverse, compounds. Among bioactive natural products identified 55% are antibiotics, both antibacterial and antifungal, and 23% have antitumor or cytotoxic properties; also compounds with antiparasitic, anti-inflammatory, immunosuppressive, antiviral, insecticidal, neuroprotective, anti-arthritic activities were found. Our findings suggest that over time, through samples collected from different precipitation events, and space, in different sampling places, we can have access to a great diversity of Actinobacteria producing an extraordinary reservoir of bioactive natural products, from remote and very distant origins, thus highlighting the atmosphere as a contrasted source for the discovery of novel compounds of relevance in medicine and biotechnology.

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Section: Taxonomic Identification and Phylogenetic Analyses Of Bioactive Isolatesmentioning

confidence: 99%

Bioactive Natural Products in Actinobacteria Isolated in Rainwater From Storm Clouds Transported by Western Winds in Spain

et al. 2021

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“…1) (Kim et al, 2006). Salaceyin A and B were originally isolated and characterized as antifungal and antitumor compounds (Kim et al, 2006;Park et al, 2007), but their mechanism of action is not known. A series of phenolic lipids compounds has been shown to inhibit bacterial, fungal, protozoan, and parasite growth, and this may be due to their interactions with proteins and/or on their membrane-disturbing properties (Stasiuk and Kozubek, 2010).…”

Section: Resultsmentioning

confidence: 99%

“…They were also evaluated for antifungal activities against plant pathogenic fungi. Salaceyin A showed antifungal activity against Cladosporium cucumerinum, Colletotrichum orbiculare and Phytophthora capsici at 64 µg/mL, while salaceyin B was less effective (Park et al, 2007).…”

Section: Introductionmentioning

confidence: 99%

6-alkylsalicylic acid analogues inhibit in vitro ATPase activity of heat shock protein 90

Moon

Choi

et al. 2010

Arch. Pharm. Res.

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The molecular chaperone heat shock protein 90 (Hsp90) is responsible for maintaining the correct folding and stability of many signaling proteins. It is a promising target of cancer therapeutics and several other diseases, including neurodegenerative disease, nerve injuries, inflammation, and infection. In an effort to identify new Hsp90 inhibitors from natural sources using an in vitro ATPase inhibition assay, two 6-alkylsalicylic acid analogues, salaceyin A and B were identified from the culture extract of Streptomyces. Salaceyin A and B exhibited moderate ATPase inhibitory activities with IC(50) values of 68.3 and 65.2 μM, respectively. Binding of salaceyins to human Hsp90α was examined by competition binding experiments with ATP-Sepharose beads. However, the compounds exhibited no degradation activity of Hsp90 client proteins, Her2, c-Raf, or Akt.

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“… reported that Salaceyin A isolated from the culture broth of Streptomyces laceyi MS53 showed antifungal activity against P. capsici at 64 µg ml −1 for MIC. However, Staurosporine isolated from Streptomyces roseoflavus strain LS‐A24 completely inhibited the mycelial growth of P. capsici at 1 µg ml −1 for MIC .…”

Section: Discussionmentioning

confidence: 96%

Antagonism of antifungal metabolites from Streptomyces griseus H7602 against Phytophthora capsici

Nguyen

Naing

Lee

et al. 2014

J. Basic Microbiol.

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In this study, evidences for antagonism were established by production of antifungal metabolites from Streptomyces griseus H7602, which were active to inhibit mycelial growth of Phytophthora capsici in the in vitro assays. Mycelial growth and zoosporangia formation of P. capsici was strongly inhibited in the medium containing the cell free culture filtrate of S. griseus H7602. Antifungal metabolites from the cell free culture filtrate of S. griseus H7602 showed substantial antagonistic effects on P. capsici. In addition, a purified antifungal compound was separated from the antifungal metabolites of S. griseus H7602 and identified to be 1H-pyrrole-2-carboxylic acid (PCA) by spectra analyses. PCA showed strong antifungal activity and was evaluated for the first time for its antagonism against P. capsici under in vitro conditions. Minimum inhibitory concentration (MIC) value of PCA was low (4 µg ml(-1)), and the mycelial growth of P. capsici was almost inhibited at concentration of 64 µg ml(-1). This study suggests that the PCA may be useful as biofungicides against P. capsici, and the prominent antagonism of antifungal metabolites from S. griseus H7602 highlights it as a candidate for biocontrol of P. capsici.

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Antifungal activity of salaceyin A against Colletotrichum orbiculare and Phytophthora capsici

Cited by 9 publications

References 22 publications

Bioactive Natural Products in Actinobacteria Isolated in Rainwater From Storm Clouds Transported by Western Winds in Spain

Bioactive Natural Products in Actinobacteria Isolated in Rainwater From Storm Clouds Transported by Western Winds in Spain

6-alkylsalicylic acid analogues inhibit in vitro ATPase activity of heat shock protein 90

Antagonism of antifungal metabolites from Streptomyces griseus H7602 against Phytophthora capsici

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