Antifungal activity of Rhopalurus crassicauda venom against Candida spp.

Zottich, Umberto; Oliveira, Isadora Sousa de; Fereira, Isabela Gobbo; Cerni, Felipe Augusto; Bordon, Karla de Castro Figueiredo; Arantes, Eliane Candiani; Gomes, Valdirene Moreira; Dias, Germana Bueno; Pucca, Manuela Berto

doi:10.1016/j.toxcx.2022.100120

Cited by 1 publication

(2 citation statements)

References 22 publications

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“…Generally, drugs used to treat Candida infections are poorly effective against biofilms, triggering the development of antifungal resistance [ 25 ]. This has led to the search for new molecules that can improve antifungal therapies through the inhibition of planktonic growth, adhesion, biofilm formation, and other virulence factors such as hyphae production by Candida species [ 26 , 27 , 28 , 29 , 30 ].…”

Section: Discussionmentioning

confidence: 99%

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Antifungal and Antibiofilm Activity of Colombian Essential Oils against Different Candida Strains

Ruiz-Duran

Torres²,

Stashenko

et al. 2023

Antibiotics

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Most Candida species are opportunistic pathogens with the ability to form biofilms, which increases their resistance to antifungal drug therapies and the host immune response. Essential oils (EOs) are an alternative for developing new antimicrobial drugs, due to their broad effect on cellular viability, cell communication, and metabolism. In this work, we evaluated the antifungal and antibiofilm potential of fifty EOs on C. albicans ATCC 10231, C. parapsilosis ATCC 22019, and Candida auris CDC B11903. The EOs’ antifungal activity was measured by means of a broth microdilution technique to determine the minimum inhibitory and fungicidal concentrations (MICs/MFCs) against the different Candida spp. strains. The effects on biofilm formation were determined by a crystal violet assay using 96-well round-bottom microplates incubated for 48 h at 35 °C. The EOs from Lippia alba (Verbenaceae family) carvone-limonene chemotype and L. origanoides exhibited the highest antifungal activity against C. auris. The L. origanoides EOs also presented antifungal and antibiofilm activity against all three Candida spp., thus representing a promising alternative for developing new antifungal products focused on yeast infections, especially those related to biofilm formation, virulence factors, and antimicrobial resistance.

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Section: Discussionmentioning

confidence: 99%

“…Biofilm formation is a key attribute of the pathogenic traits of the Candida species which is becoming a major problem in clinical settings due to its rapid emergence and high antifungal resistance [ 26 , 27 ]. It has been estimated that most clinical and environmental isolates of Candida are related to biofilm structures [ 28 ].…”

Section: Discussionmentioning

confidence: 99%