Antifungal activity of polymer-based copper nanocomposite coatings

Cioffi, Nicola; Torsi, Luisa; Ditaranto, Nicoletta; Sabbatini, Luigia; Zambonin, P. G.; Tantillo, Giuseppina; Ghibelli, Lina; D'alessio, Maria; Bleve-Zacheo, T.; Traversa, Enrico

doi:10.1063/1.1794381

Cited by 168 publications

(87 citation statements)

References 20 publications

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“…The possibility of embedding copper nanoparticles (Cu-NPs) in inert polymeric matrices to obtain nanostructured bioactive coatings for different applications has been reported by the authors in various studies [11][12][13]. Indeed, a marked biological activity of these nanomaterials against a wide range of different living organisms (Saccharomyces cerevisiae fungi, Escherichia coli, Staphylococcus aureus, Listeria monocytogenes bacteria and moulds) has been demonstrated.…”

Section: Introductionmentioning

confidence: 99%

“…The procedure consisted in mixing the ZnO-NPs white powder (or the Cu-NPs colloid) with the consolidants/waterrepellents at various % w/w concentrations [11,12,14]. Estel1000, Estel1100, and Silo111 are ready-to-use materials dispersed in white spirit D40 and based on siloxane oligomers (Silo111-water-repellant), tetraethoxysilane (Estel1000-consolidant), and a combination of tetraethoxysilane and siloxane oligomers (Estel1100-consolidant/water-repellant).…”

Section: Nanocomposites Preparationmentioning

confidence: 99%

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Development of a novel conservation treatment of stone monuments with bioactive nanocomposites

et al. 2015

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In this study a conservation treatment of stone monuments meant for consolidation, protection, and inhibition of biofilm formation is proposed. The method is developed as a part of a systematic investigation aimed at producing nanocomposite coatings able to exert a marked biological activity over a long period of time thanks to their peculiar structure. Zinc oxide nanoparticles, synthesised by means of simple and reproducible electrochemical procedures, are embedded in commercially available and commonly used consolidant/water repellent matrices to obtain nanostructured materials. Products based on tetraethoxysilane and/or polysiloxanes were tested. In a first step the nanomaterials were applied on stone samples and studied with scanning electron microscopy and spectrophotocolorimetry. Then, in situ experimentation was undertaken by applying nanocomposite coatings on the exterior of a 12th-century church in the south of Italy. The performances of the ZnO-nanoparticles based composite coating were compared with a previously investigated copper nanoparticles based material, successfully tested and monitored in situ for more than two years. Finally, preliminary tests on the inhibitory effect on the growth of the fungus Aspergillus niger were also carried out. The results showed that in case of zinc oxide a tenfold higher concentration of nanoparticles as compared with Cu-NPs can be utilized in the matrices without affecting the colour of the stone substrate, which means that the new material should be able to exert a long-lasting biocide activity. Laboratory and in situ tests of the developed innovative nanomaterials yielded very promising, though preliminary, results in terms of chromatic changes, morphological characteristics and bioactivity. Constant monitoring of the coatings will be continued in order to obtain all necessary information on their long term behaviour and inhibition of biological colonisation.

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Section: Introductionmentioning

confidence: 99%

Section: Nanocomposites Preparationmentioning

confidence: 99%

Development of a novel conservation treatment of stone monuments with bioactive nanocomposites

et al. 2015

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“…[39][40][41][42][43][61][62][63][64][65][66][67][73][74][75][81][82][83][86][87][88][89][90][91][92][93][94] Most of these applications involve leaching metallic ions in order to disrupt the membrane of bacteria and prevent the proliferation of bacteria on the surface of the device. Specifically, silver ions are capable of interacting with and disrupting the mitochondrial respiratory chain of bacteria, directly impacting ATP production and leading to DNA damage in the bacteria.…”

Section: Metallic-based Coatingsmentioning

confidence: 99%

“…bacteria), whereas copper has a stronger effect on eukaryotes such as fungi. 86 Therefore, to develop a non-drug eluting coating capable of preventing the growth of fungal biofilm, Cioffi et al 86 electrochemically synthesized a copper nanoparticle coating in an alkyl ammonium micellar solution. The nanoparticles were composed of two layers: an inner copper oxide layer and outer shell of either polyvinylmethylketone (PVMK), polyvinylchloride (PVC), or polyvinylidenefluoride (PVDF).…”

mentioning

confidence: 99%

“…The nanoparticles were composed of two layers: an inner copper oxide layer and outer shell of either polyvinylmethylketone (PVMK), polyvinylchloride (PVC), or polyvinylidenefluoride (PVDF). 86 The colloid suspension of nanoparticles was then spincoated onto glass plates. 86 The coatings were shown to be capable of inhibiting growth of Saccharomyces cerevisiae yeast and that the antifungal effect was dependent upon the concentration of copper nanoparticles in the coating.…”

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confidence: 99%

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Emerging technologies for long-term antimicrobial device coatings: advantages and limitations

Cyphert

Recum

2017

Exp Biol Med (Maywood)

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This work provides an overview, with advantages and limitations of the most recently developed antibacterial coating technologies, enabling other researchers in the field to more easily determine which technology is most advantageous for them to further develop and pursue. AbstractOver the past 20 years, the field of antimicrobial medical device coatings has expanded nearly 30-fold with technologies shifting their focus from diffusion-only based (short-term antimicrobial eluting) coatings to long-term antimicrobial eluting and intrinsically antimicrobial functioning materials. A variety of emergent coatings have been developed with the goal of achieving long-term antimicrobial activity in order to mitigate the risk of implanted device failure. Specifically, the coatings can be grouped into two categories: those that use antibiotics in conjunction with a polymer coating and those that rely on the intrinsic properties of the material to kill or repel bacteria that come into contact with the surface. This review covers both long-term drug-eluting and non-eluting coatings and evaluates the inherent advantages and disadvantages of each type while providing an overview of variety applications that the coatings have been utilized in.

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Bioavailability, Trophic Transfer, and Toxicity of Manufactured Metal and Metal Oxide Nanoparticles in Terrestrial Environments

Unrine

Bertsch

Hunyadi

2008

Nanoscience and Nanotechnology

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Antifungal activity of polymer-based copper nanocomposite coatings

Cited by 168 publications

References 20 publications

Development of a novel conservation treatment of stone monuments with bioactive nanocomposites

Development of a novel conservation treatment of stone monuments with bioactive nanocomposites

Emerging technologies for long-term antimicrobial device coatings: advantages and limitations

Bioavailability, Trophic Transfer, and Toxicity of Manufactured Metal and Metal Oxide Nanoparticles in Terrestrial Environments

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