Antifungal activity of oosponol, oospolactone, phyllodulcin, hydrangenol, and some other related compounds.

Nozawa, Koohei; Yamada, Mikiko; Tsuda, Yoshiko; Kawai, Ken‐ichi; Nakajima, Shōichi

doi:10.1248/cpb.29.2689

Cited by 148 publications

(62 citation statements)

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“…Hydrangea Dulcis Folium (HDF, Amacha in Japanese, Kamrocha in Korean), the fermented and dried leaves of Hydrangea macrophylla SERINGE var. thunbergii MAKINO, is a saxifragaceous plant with anticoccidial, 13) antifungal, 14) antiulceric, 15) anti-allergic, 16) anti-hypercholesterolemic, 15) and anti-oxidative activities. 17) Recently Zhang et al 18) reported that hydrangenol, isolated from H. macrophylla var.…”

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Improvement of Diabetic Complication by Hydrangea Dulcis Folium in Streptozotocin-Induced Diabetic Rats

Kim

Lyu

et al. 2009

Biological & Pharmaceutical Bulletin

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The improvement of diabetic complications such as lipid lowering and anti-oxidative potential of Hydrangea Dulcis Folium (HDF) was studied in streptozotocin-induced diabetic rats. Male Sprague-Dawley rats were divided into 3 groups after induction of streptozotocin (STZ)-diabetes: normal control; diabetic control; diabetic-HDF supplement (hot water extract 40 g/kg diet); and fed experimental diets for 3weeks. Serum glucose and insulin concentrations, serum lipid profile, intraperitoneal glucose tolerance test, and liver cytosolic antioxidant enzyme levels were measured. The HDF supplement significantly decreased serum glucose concentration, increased insulin level, and improved glucose homeostasis in diabetic control rats. The total cholesterol and triglyceride concentrations in the serum and liver were markedly reduced by HDF treatment in STZ-diabetic rats. Moreover, low density lipoprotein (LDL)-, VLDL-, and high density lipoprotein (HDL)-cholesterol levels were ameliorated in HDF supplemented diabetic rats. Decreased fecal excretions of cholesterol, triglyceride, and bile acid in diabetic rats were significantly increased by HDF consumption. HDF supplement reversed the effects of the oxidative stress system of liver in diabetic rats. Lipid peroxidation of diabetic rats, assessed by thiobarbituric acid reactive substance (TBARS), as well as superoxide dismutase (SOD) activities were significantly increased, and glutathione contents were decreased in diabetic rats. HDF supplement reverted these parameters to near normal value. Our data suggest that HDF supplement could be used to improve the glucose and lipid metabolism as well as to reduce the imbalance between the generation of reactive oxygen species (ROS) and the scavenging enzyme activity in preventing diabetic complications.

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Improvement of Diabetic Complication by Hydrangea Dulcis Folium in Streptozotocin-Induced Diabetic Rats

Kim

Lyu

et al. 2009

Biological & Pharmaceutical Bulletin

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“…var. thunbergii MAKINO, is a saxifragaceous plant with anticoccidial, 1) antifungal, 2) anti-ulceric, 3) antiallergic, 4) anti-hypercholesterolemic, 3) anti-oxidative, 5) and cholagogic activities.…”

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confidence: 99%

Suppression byHydrangeae Dulcis FoliumofD-Galactosamine-induced Liver Injuryin Vitroandin Vivo

Nakagiri

Hashizume

Kayahashi

et al. 2003

Bioscience, Biotechnology, and Biochemistry

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“…수국차 잎은 이외에도 항 곰팡이성 (Nozawa et al 1981), 항궤양성 (Yamahara et al 1994), 항콜레스테롤성 (Yamahara et al 1994), 항산화성 (Yamahara et al 1995), 항알레르 기성 (Yoshikawa et al 1992 …”

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Quality Characteristics of Sulgidduk Added with Hydrangea serrata Seringe Powder

Choi¹,

Kim²

2011

The Korean Journal of Community Living Science

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To find the optimum proportion of Hydrangea serrata Seringe(HSS) powder, rice cakes were prepared with different quantities of Hydrangea serrata Seringe powder instead of sugar. Technical and sensory examinations were then conducted. The proximate components of the HSS leaves were 3.48% crude protein, 6.45% crude lipid, 7.98% crude fiber and 9.32% crude ash. The pH values of samples which replaced 25%, 50%, 75% and 100% of sugar with the HSS powder were significantly decreased(p<0.05). The groups with HSS powder showed a lower L value(lightness) and a value(redness) than that of the control group. The B value(yellowness) of the Sulgidduk containing the HSS powder was higher than that of the control group. The hardness of HS2 and HS3 was increased by the addition of the HSS powder. The adhesiveness of Sulgidduk groups with the HSS powder was higher than that of the control group. Springiness was not changed by adding the HSS powder. The cohesiveness of the Sulgidduk was significantly reduced by adding the HSS powder(p<0.001). The groups with no sugar showed the highest gumminess and chewiness. The added HSS powder caused both a darker color and a stronger odor, but the sweetness of the Sulgidduk which replaced the sugar with the HSS powder was decreased compared to the control group. The moisture content and the hardness was not affected by the addition of the HSS powder. The preference of color and taste was not changed by adding the HSS powder. The preference of flavor of the Sulgidduk with the HSS powder showed higher than that of the control. Overall acceptability of the Sulgidduk did not show any significant differences. As a result, Sulgidduk can be replaced 25% and 50% of sugar with the Hydrangea serrata Seringe powder.

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Antifungal activity of oosponol, oospolactone, phyllodulcin, hydrangenol, and some other related compounds.

Cited by 148 publications

References 0 publications

Improvement of Diabetic Complication by Hydrangea Dulcis Folium in Streptozotocin-Induced Diabetic Rats

Improvement of Diabetic Complication by Hydrangea Dulcis Folium in Streptozotocin-Induced Diabetic Rats

Suppression byHydrangeae Dulcis FoliumofD-Galactosamine-induced Liver Injuryin Vitroandin Vivo

Quality Characteristics of Sulgidduk Added with Hydrangea serrata Seringe Powder

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