Antifungal activity of menthol alone and in combination on growth inhibition and biofilm formation of Candida albicans

Norouzi, Naqibullah; Alizadeh, Fahimeh; Khodavandi, Alireza; Jahangiri, Mohammad

doi:10.1016/j.hermed.2021.100495

Cited by 16 publications

(4 citation statements)

References 46 publications

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“…3). Menthol signi cantly inhibits Candida albicans, Aspergillus niger, and other fungi [30]. L-menthone also has an excellent inhibitory effect on Fusarium sambucinum and Rhizoctonia solani.…”

Section: Discussionmentioning

confidence: 99%

Study on the inhibitory activity and mechanism of Mentha haplocalyx essential oils nanoemulsion against Fusarium oxysporum growth

Liao,

Wen,

Nie

et al. 2024

Preprint

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As a green and environmentally friendly natural product, Mentha haplocalyx essential oil (MEO) inhibits F. oxysporum, but its field application is limited by its poor water solubility. The nanoemulsion can improve bioavailability and provide a green way to prevent and control P. notoginseng root rot. In this study, Tween-80 and anhydrous ethanol were selected as carriers, and the ultrasonic method was adopted to prepare a nanoemulsion of MEO (MNEO) with an average particle size of 26.07 nm. Compared with traditional emulsion of MEO (MTEO, MEO dissolved in an aqueous solution of 2% DMSO and 0.1% Tween 80), MNEO was superior in inhibiting F. oxysporum in terms of spore germination, hyphal growth, and minimum inhibitory concentration (MIC). Through transcriptomic and metabolomic analyses, it was found that both MNEO and MTEO can inhibit the Glycolysis/Gluconeogenesis and Starch and Sucrose metabolism pathways of F. oxysporum. Nevertheless, MNEO can inhibit the expression of more genes and metabolites. In addition, some key genes in meiosis, ribosome, and ribosome biogenesis were also significantly downregulated only under MNEO treatment. These genes and metabolites provide valuable information for the later prevention and control of F. oxysporum and provide a theoretical basis for better utilization of MEO resources to develop plant-derived bacteriostatic agents and agricultural modernization and ecological development.

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Section: Discussionmentioning

confidence: 99%

Study on the inhibitory activity and mechanism of Mentha haplocalyx essential oils nanoemulsion against Fusarium oxysporum growth

Liao,

Wen,

Nie

et al. 2024

Preprint

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“…Scalp infections such as seborrheic dermatitis, scalp psoriasis and candidiasis are caused by a fungus called Candida albicans. Its treatment includes an antifungal medication, such as an antifungal shampoo, targeting DNA repair or ergosterol synthesis (Norouzi et al 2021;Ivanov et al 2021). Marketed synthetic antifungal shampoos which contain ketoconazole or ciclopirox olamine as an active ingredient can have a number of side effects such as alopecia, eye irritation, dry hair, abnormal hair texture, dry scalp and headache etc.…”

Section: Discussionmentioning

confidence: 99%

Comparative antifungal potential of six formulated herbal shampoos against Candida albicans causing Seborrheic dermatitis

Chattar,

Pimple,

Kuchekar

et al. 2024

MBJ

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Cosmetics have been used by humans since centuries for variety of purposes, including enhancing appearance, protection and cleansing. Herbal ingredients have been used in cosmetics for their natural and beneficial properties. When combined, herbal ingredients and cosmetics can provide a number of benefits, including improved skin health, protection from the sun and a more youthful appearance. Shampoo is a key part of hair cosmetics which is used to clean scalp and hair. There are many scalp infections such as Seborrheic Dermatitis, Scalp Psoriasis and Candidiasis which are caused by the fungus Candida albicans and are treated by using antifungal shampoos. But it was observed that marketed antifungal shampoos cause various side effects such as alopecia, eye irritation, dry hair, abnormal hair texture, dry scalp and headache etc. The current study focuses on comparison of antifungal potential of six herbal shampoos developed using isolated phytoconstituents such as Rutin, Eugenol, Camphor and Menthol; as well as their combination. The results showed that antifungal potential of all the six developed herbal shampoos against Candida albicans causing Seborrheic dermatitis is comparable to the marketed synthetic antifungal shampoo. Hence, it is concluded that the six developed shampoos can be successfully used to treat Seborrheic dermatitis caused by Candida albicans.

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“…14 Saponin sebagai antifungi bekerja dengan cara mengganggu stabilitas membran sel; tanin bekerja dengan cara menghambat sintesis kitin pada candida; dan mentol menghambat pembentukan biofilm C. albicans dengan cara menginduksi permeabilitas membran plasma. 11,14,15 Uji disc diffusion yang dilakukan Audreylia et al 9 untuk mengetahui zona hambat fungi menunjukkan bahwa paper disc yang direndam dalam minyak peppermint menunjukkan rerata luas zona hambat sebesar 31,67 mm pada koloni C. albicans ATCC 10231.…”

Section: Pendahuluanunclassified

Efek Antifungi Sediaan Pasta Gigi Ekstrak Teh Hijau (Camellia sinensis L.) dan Peppermint (Menthapiperita) terhadap Candida albicans

Wangguai,

Sugiaman,

Widowati

2024

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Candida albicans are normal flora of the oral cavity that are opportunistically pathogenic and becomes the main causative agent of oral candidiasis. The addition of herbal ingredients to toothpaste is a solution to resistance and synthetic antifungal side effects. Green tea and peppermint extracts are known to have an antifungal role with various active ingredients such as catechins, tannins, flavonoids, terpenoids, alkaloids, and saponins. This study aimed to determine the antifungal effect of toothpaste preparations of green tea extract and peppermint on C. albicans. This study used the agar diffusion method at several concentrations of green tea and peppermint extracts in toothpaste preparations, namely 1000 mg/ml, 500 mg/ml, 250 mg/ml, 125 mg/ml, 62,5 mg/ml and 31,25 mg/ml. The results showed that there was an antifungal effect of green tea and peppermint extract toothpaste against C. albicans at a concentration of 1000 mg/ml with an average inhibition zone diameter of 7.19 mm. The smallest inhibition zone was 125 mg/ml with a diameter of 1.16 mm. In conclusion, green tea and peppermint extract toothpastes have antifungal effects. The higher the concentration of the extract used in the toothpaste preparation, the greater the antifungal inhibition zone formed. Keywords: Candida albicans; antifungal toothpaste; green tea; peppermint Abstrak: Candida albicans merupakan flora normal rongga mulut yang bersifat patogen oportunistik dan menjadi agen penyebab utama kandidiasis oral. Penambahan bahan herbal pada pasta gigi mikroba merupakan solusi terhadap resistensi dan efek samping antijamur sintetik. Ekstrak teh hijau dan peppermint diketahui memiliki peran sebagai antijamur dengan berbagai kandungan aktifnya seperti katekin, tanin, flavonoid, terpenoid, alkaloid dan saponin. Mengetahui efek antifungi sediaan pasta gigi ekstrak teh hijau dan peppermint terhadap C. albicans. Penelitian ini menggunakan metode difusi agar dengan beberapa konsentrasi ekstrak teh hijau dan peppermint dalam sediaan pasta gigi yaitu 1000 mg/ml, 500 mg/ml, 250 mg/ml, 125 mg/ml, 62,5 mg/ml dan 31,25 mg/ml. Hasil penelitian memperlihatkan adanya efek antifungi pada pasta gigi ekstrak teh hijau dan peppermint terhadap C. albicans pada konsentrasi 1000 mg/ml dengan diameter zona hambat rata-rata sebesar 7,19 mm. Zona hambat terkecil dari konsentrasi 125 mg/ml dengan diameter 1,16 mm. Simpulan penelitian ini ialah pasta gigi ekstrak teh hijau dan peppermint memiliki efek antijamur. Semakin tinggi konsentrasi ekstrak yang digunakan dalam sediaan pasta gigi maka semakin besar zona hambat antijamur yang terbentuk. Kata kunci: Candida albicans; pasta gigi antifungi; teh hijau; peppermint

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Antifungal activity of menthol alone and in combination on growth inhibition and biofilm formation of Candida albicans

Cited by 16 publications

References 46 publications

Study on the inhibitory activity and mechanism of Mentha haplocalyx essential oils nanoemulsion against Fusarium oxysporum growth

Study on the inhibitory activity and mechanism of Mentha haplocalyx essential oils nanoemulsion against Fusarium oxysporum growth

Comparative antifungal potential of six formulated herbal shampoos against Candida albicans causing Seborrheic dermatitis

Efek Antifungi Sediaan Pasta Gigi Ekstrak Teh Hijau (Camellia sinensis L.) dan Peppermint (Menthapiperita) terhadap Candida albicans

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