Antifungal activity of lichen compounds against dermatophytes: a review

Furmanek, Łukasz; Czarnota, Paweł; Seaward, M. R. D.

doi:10.1111/jam.14209

Cited by 23 publications

(27 citation statements)

References 67 publications

(264 reference statements)

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“…The genus Ramalina Ach. is one of the best known lichen genera, easily recognized and widely studied by scientists in various fields of research, including biomonitoring of environmental changes ( Agnan et al 2016 ; López Berdonces et al 2016 ), evaluation of impacts of industrial activities to the environment ( Domínguez-Morueco et al 2015 ), biotoxicity ( Anar et al 2015 ), use in cancer therapy ( Lee et al 2016 ; Suh et al 2017 ) and other human diseases ( Kim et al 2018 ; Furmanek et al 2019 ), biotechnologies ( Biosca et al 2016 ), decontamination ( Candan et al 2017 ), and even in ethnological studies of rural human populations ( Devkota et al 2017 ).…”

Section: Introductionmentioning

confidence: 99%

The fruticose genera in the Ramalinaceae (Ascomycota, Lecanoromycetes): their diversity and evolutionary history

Spjut¹,

Simon²,

Guissard³

et al. 2020

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We present phylogenetic analyses of the fruticose Ramalinaceae based on extensive collections from many parts of the world, with a special focus on the Vizcaíno deserts in north-western Mexico and the coastal desert in Namibia. We generate a four-locus DNA sequence dataset for accessions of Ramalina and two additional loci for Niebla and Vermilacinia. Four genera are strongly supported: the subcosmopolitan Ramalina, the new genus Namibialina endemic to SW Africa, and a duo formed by Niebla and Vermilacinia, endemic to the New World except the sorediate V. zebrina that disjunctly occurs in Namibia. The latter three genera are restricted to coastal desert and chaparral where vegetation depends on moisture from ocean fog. Ramalina is subcosmopolitan and much more diverse in its ecology. We show that Ramalina and its sister genus Namibialina diverged from each other at c. 48 Myrs, whereas Vermilacinia and Niebla split at c. 30 Myrs. The phylogeny of the fruticose genera remains unresolved to their ancestral crustose genera. Species delimitation within Namibialina and Ramalina is rather straightforward. The phylogeny and taxonomy of Vermilacinia are fully resolved, except for the two youngest clades of corticolous taxa, and support current taxonomy, including four new taxa described here. Secondary metabolite variation in Niebla generally coincides with major clades which are comprised of species complexes with still unresolved phylogenetic relationships. A micro-endemism pattern of allopatric species is strongly suspected for both genera, except for the corticolous taxa within Vermilacinia. Both Niebla and saxicolous Vermilacinia have chemotypes unique to species clades that are largely endemic to the Vizcaíno deserts. The following new taxa are described: Namibialinagen. nov. with N. melanothrix (comb. nov.) as type species, a single new species of Ramalina (R. krogiae) and four new species of Vermilacinia (V. breviloba, V. lacunosa, V. pustulata and V. reticulata). The new combination V. granulans is introduced. Two epithets are re-introduced for European Ramalina species: R. crispans (= R. peruviana auct. eur.) and R. rosacea (= R. bourgeana auct. p.p). A lectotype is designated for Vermilacinia procera. A key to saxicolous species of Vermilacinia is presented.

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Section: Introductionmentioning

confidence: 99%

The fruticose genera in the Ramalinaceae (Ascomycota, Lecanoromycetes): their diversity and evolutionary history

Spjut¹,

Simon²,

Guissard³

et al. 2020

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“…Encouraged by these results, the next step was the structure elucidation by standard procedure after the bioactive compound purification. Previous work with the lecanoric acid has demonstrated the chemical shifts of compounds in NMR [28][29][30] . The NMR, microcrystal and TLC results confirmed the presence of lichen compound lecanoric acid.…”

Section: Mfcmentioning

confidence: 99%

Antimicrobial and Antiproliferative Activities of Depside Compound Isolated from the Mycobiont Culture of Parmotrema austrosinense (Zahlbr.) Hale

Rajendran¹,

Poornima²,

Ponmurugan³

2020

J Pure Appl Microbiol

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Substances which are normally secondary metabolites in a lichen are known to possess various medicinal properties but little is known about the biological activities of compounds present in these mycobiont culture extract. The objectives of the present study were isolation and optimization of growth conditions of the mycelia from Parmotrema austrosinense and assess the antiproliferative and antimicrobial activities of acetone extracts. The extraction of bioactive compound from mycobiont culture was achieved by using acetone and standard Soxhlet extraction procedures. The culture extract was subjected to silica gel column chromatography and detection of compound in thin layer chromatography. HPLC, UV vis, IR spectra, microcrystallization and NMR were done for the purified compound. The antimicrobial activity in the extracts were assayed using the standard disc diffusion and broth microdilution protocol against microbial strains. The lecanoric acid in the extracts was purified and MTT method was applied to assess antiproliferative activity against DLA cancer cells. The culture extract containing lecanoric acid exhibited antimicrobial activity against the test strains with the Minimum Inhibitory Concentrations varied between 0.83±0.28 and 2.3±1.5 mg mL−1. The lecanoric acid inhibited the growth of DLA cancer cells with inhibitory concentration (IC50) of about 42±1.5 µg mL−1. Conclusion: The result of the present study suggests that this compound might possess potent antitumor property and should be further analysed using appropriate animal model and clinical trials.

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“…The fungal metabolites tested here showed no activity against the evaluated microorganisms. According to Furmanek et al (2019), the microdilution method assesses the effectiveness of concentrations of used substances . In this study, the Gurgel et al 89 crude aqueous extract to access the antimicrobial activity was used, and the substances that could present the inhibition of microbial growth were probably not in an effective concentration (not detected by this method), thus it is necessary to concentrate the metabolites in order to access this biological activity.…”

Section: Biological Activitiesmentioning

confidence: 99%

Biological activity and production of metabolites from Amazon endophytic fungi

Gurgell¹,

Rodrigues²,

Matias³

et al. 2020

Afr. J. Microbiol. Res.

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Obtaining bioactive metabolites from endophytic microorganisms has become increasingly more interesting in the last few decades, since endophytes are known for their biotechnological potential. However, studies involving endophytic microbiota from tropical hosts are still scarce. In this study, the production of bioactive metabolites from endophytic fungi isolated from Amazonian plants were evaluated. Two fungi (Talaromyces sp. F15 and Aspergillus sp. F18) isolated from Myrcia guianensis (Myrtaceae) and one (Penicillium sp. F3) isolated from Euterpe precatoria (Arecaceae) were analysed. The fungi were cultivated in liquid medium and their metabolites were tested for antimicrobial, antioxidant and cytotoxic activity. Amylase, cellulase and lipase production, as well as biosurfactant production, were also evaluated. The metabolites of Aspergillus sp. F18 showed 69.4% antioxidant activity against DPPH free-radical molecules and cytotoxic activity against A. salina. Penicillium sp. F3 showed cytotoxic activity and stood out as the best amylase producer (31 U/ml). Talaromyces sp. F15 was the best lipase producer (4.5 U/ml) and the best biosurfactant source, with 33.3% emulsification index. These Amazonian host-associated fungi showed biotechnological potential, which are believed should be further investigated in order to elucidate the chemical structure of the metabolites responsible for the activities described here, as well as optimize their production.

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Antifungal activity of lichen compounds against dermatophytes: a review

Cited by 23 publications

References 67 publications

The fruticose genera in the Ramalinaceae (Ascomycota, Lecanoromycetes): their diversity and evolutionary history

The fruticose genera in the Ramalinaceae (Ascomycota, Lecanoromycetes): their diversity and evolutionary history

Antimicrobial and Antiproliferative Activities of Depside Compound Isolated from the Mycobiont Culture of Parmotrema austrosinense (Zahlbr.) Hale

Biological activity and production of metabolites from Amazon endophytic fungi

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